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Showing 1 to 1 of 1 for “"Antagonist; Human PXR; Reporter Gene Assay"”.
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Studying the Specificity of hPXR Antagonists Using a Panel of Cell-based Assays
<p>The pregnane X receptor (PXR or SXR; NR1I2) is a member of the nuclear receptor superfamily. It activates the transcription of a large network of genes including cytochrome P450 (CYP) and Mdr1 which play critical roles in chemicals metabolism and transportation. Induction of CYPs contributes to …