Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 866 for “"Antagonist"”.
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Preclinical Pharmacology of the MDM2 Antagonist Nutlin-3a
<p>Nutlin-3a is an MDM2-p53 interaction antagonist that is under investigation in preclinical models for a variety of pediatric malignancies, including neuroblastoma, retinoblastoma, leukemia, and rhabdomyosarcoma. In the current research, we conducted preclinical pharmacology studies of nutlin-3a …
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Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist
… diaryl group revealed in the prototypical antagonist/inverse agonist SR141716 (Rimonabant) that was presumed to interact with a unique region in the CB1 receptors. Based on our preliminary results we identified a novel series of 1,2,3-triazole ester and keto derivatives as lead compounds …
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IAP antagonist Grim mediates cell death through divergent pathways
… or enhanced by the accumulation of “IAP antagonists”, which promote cell death by utilizing their N-terminal IAP binding motifs (IBMs) to interact with IAPs, to displace caspases from IAP-binding, and to promote IAPs autoubiquitination. Herein, we demonstrate that a Drosophila IAP …
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Self-assembly of a gonadotropin-releasing hormone antagonist-Teverelix
Peptide and protein aggregation (self-assembly) has been an important topic for many years, since it is implicated in a range of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s and Huntington’s Diseases. At the same time, it also represents a significant challenge for the …
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Identification of microRNA 302 as an antagonist to p63 expression
Die p53-Familie von Transkriptionsfaktoren ist essentiell in der Tumorsuppression, während der Entwicklung und in der Gewebehomöostase. MicroRNAs sind kleine, einzelsträngige RNAs, die an der Translationskontrolle und der mRNA-Stabilität beteiligt sind. Zur Untersuchung, ob microRNAs an der …
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Ethosuximide, a T-type Calcium Channel Antagonist, Reduces Alcohol Withdrawal Seizure
Alcohol is the third highest risk factor for health related problems in the world and leads to over two million deaths per year. Individuals abusing alcohol frequently cycle between drinking and withdrawal states, which among other adverse side effects can induce withdrawal seizures. Alcohol …
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SOSTDC1: A BMP/Wnt Dual Antagonist in Breast and Renal Cancers
… Blish, Kimberly Rose SOSTDC1: A BMP/WNT DUAL ANTAGONIST IN BREAST AND RENAL CANCERS Dissertation under the direction of Suzy V. Torti, Ph.D., Associate Professor of Biochemistry The bone morphogenetic protein (BMP) pathway and the Wnt pathway are signaling networks associated with …
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The use of antagonist muscle as a "catch" in explosive movement/
… 30% of the maximum force of the muscle, using an antagonist muscle as a catch could produce beneficial power amplifications. These amplifications increase as the load and muscle release rates decrease.
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Coordination of lower limb movement utilizing the agonist-antagonist myoneural interface
The agonist-antagonist myoneural interface is a novel surgical construct that shows promise as a method of providing persons with amputation proprioceptive sensation of movement and force. This thesis aims to quantify the volitional coordination capabilities of the agonist- antagonist myoneural …
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Design and evaluation of a biomimetic agonist-antagonist active knee prosthesis
… actuators positioned in parallel in an agonist-antagonist configuration. This investigation hypothesizes that the biomimetic active-knee prosthesis, with a variable impedance control, can improve unilateral transfemoral amputee locomotion in level-ground walking, reducing the metabolic cost of …
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The Effects of a GnRH Antagonist, Cetrorelix, on Ovarian Function in Cattle
… conducted to determine the effects of a GnRH antagonist, cetrorelix, on the follicular dynamics in cattle during different stages of follicular growth and in different endocrine milieus. The specific objective was to test the hypothesis that cetrorelix would induce regression of the dominant …
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A Novel Interleukin-15 Receptor Antagonist for the Treatment of Rheumatoid Arthritis
… the potential of IFRA3Q1, a novel peptoid antagonist, designed to inhibit IL-15 by selectively binding to its receptor, IL-15Rα. Peptoids offer several advantages over peptides, such as increased stability, enhanced bioavailability, and reduced immunogenicity, making IFRA3Q1 a promising …
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Acute effects of dynamic stretching on flexibility and agonist-antagonist muscle activity
… delineate the effects of ADS on AROM and agonist-antagonist mean and peak EMG. The ADS protocol involved three sets of ten repetitions of leg kicks while in the supine position with the pelvis and contralateral limb fixed in extension. Participants moved the leg at the hip in a kicking motion to a …
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Design and Synthesis of a Novel Neuroprotective Brain-Targeting Amylin Receptor Antagonist
<p>Amylin receptor antagonist AC253 is a 24-amino acid peptide that provides neuroprotection against amyloid beta (Aβ)-induced cell death and toxicity. Additionally, AC253 has been shown to improve spatial memory in mouse models of Alzheimer’s disease (AD). Screening of short overlapping fragments …
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An agonist-antagonist myoneural interface for proprioception from a neurally-controlled prosthesis
… to this shortcoming, I present the agonist-antagonist myoneural interface (AMI). The AMI is comprised of 1) a surgical construct made up of two muscle-tendons - an agonist and an antagonist - surgically connected in series so that contraction of one muscle stretches the other, and 2) a …
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Mapping of the binding surface between EPHA5 and antagonist peptide by NMR spectroscopy
… A diverse spectrum of peptides that act as antagonists of Eph-ephrin with differential selectivity has previously been identified. One of these peptides, called WDC, is attractive because it has been found to antagonize the interaction between EphA5 and its ligands with high selectivity. …
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The Effect of Cholecystokinin Antagonist Lorglumide on Dopamine Levels in the Rat Caudate
Systemic administration of the CCK-A receptor antagonist lorglumide has been shown to block voltammetrically detected dopamine (DA) signals associated with slow wave depolarization (SWD) in the rat caudate (CPu). Failure to elicit KC1-induced DA signals following lorglumide treatment may be due to …
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Dopamine and reward : effects of dopamine antagonist drugs on operant and consummatory behaviours
The Herrnstein matching law was used to dissociate motoric from motivational drug-induced performance changes. The effects of neuroleptic drugs were compatible with, at low doses, a reduction in reinforcer efficacy, and at higher doses, an additional motor impairment However, the Herrnstein …
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Mimicry of Cocaine by Anti -Idiotypic Antibodies: Molecular Basis and Antagonist Drug Design
[M. Ho was supported by National Research Service Award Predoctoral Fellowship F31-DA14484 from the National Institutes of Health, University of Illinois Fellowship (1-1-10742) and On-Campus Dissertation Research Grant (1-2-16449). This work was supported by NIDA research grant R15-DA10367 and …
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