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Showing 1 to 12 of 12 for “"Anopheles stephensi"”.
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Genomics and Transcriptomics Analysis of the Asian Malaria Mosquito Anopheles stephensi
Anopheles stephensi is a potent vector of malaria throughout the Indian subcontinent and Middle East. An. stephensi is emerging as a model for molecular and genetic studies of mosquito-parasite interactions. Here we conducted a series of genomic and transcriptomic studies to improve the …
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Induction of Anopheles stephensi nitric oxide synthase by Plasmodium-derived factor(s)
… (Plasmodium spp.) infection in the mosquito Anopheles stephensi induces significant expression of A. stephensi nitric oxide synthase (AsNOS) in the midgut epithelium as early as 6 h post-infection and intermittently thereafter. This induction results in the synthesis of inflammatory levels of …
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Immunological Crosstalk between Human Transforming Growth Factor-β1 and the Malaria Vector Anopheles stephensi
… mammalian host. One candidate effector gene is Anopheles stephensi nitric oxide synthase (AsNOS), whose inducible expression and subsequent synthesis of nitric oxide (NO) limits Plasmodium development in A. stephensi. In mammals, one of the most potent physiological regulators of NOS gene …
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<i>Plasmodium</i>-Induced Nitrosative Stress in <i>Anopheles stephensi</i>: The Cost of Host Defense
… of nitric oxide (·NO) synthase. Expression of <i>Anopheles stephensi</i> ·NO synthase (<i>AsNOS</i>) is induced in the midgut epithelium beginning at 6 h following a <i>Plasmodium berghei</i>-infected blood meal. ·NO reacts readily with other biocompounds forming a variety of reactive nitrogen …
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Invasion genomics, adaptive evolution, and transcriptional plasticity of Anopheles stephensi in Ethiopia and Yemen : implications for malaria transmission and control.
The rapid expansion of Anopheles stephensi across the Horn of Africa represents a major shift in malaria transmission dynamics, particularly in urban environments. This dissertation investigates how ecological pressures, transcriptomic plasticity, and genomic adaptation shape the invasion success …
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A mosquito-specific bZIP transcription factor and the influence of a Y-specific gene on sex determination in Anopheles stephensi
… characterize a novel Y chromosome gene in An. stephensi. The aims of these experiments were to expand on the knowledge of genes involved in embryonic development and sex determination with potential application in vector control strategies. In Ae. aegypti a mosquito-specific bZIP1 transcription …
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The early zygotic genes and microRNAs in the yellow fever mosquito Aedes aegypti and the Asian malaria mosquito Anopheles stephensi
… systematic analysis of miRNAs in Ae. aegypti and Anopheles stephensi were conducted in this study. The first miRNA profiling in mosquito across all developmental stages was also performed to provide basis for future functional study. Several lineage-specific miRNAs were found highly expressed in …
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Genetically Modifying Mosquitoes Without Compromising Fitness: Can It Be Done?
… mosquitoes. We previously generated a transgenic Anopheles stephensi line with increased insulin signaling in the fat body. Surprisingly, these transgenic mosquitoes survived significantly longer than their non-transgenic siblings, while in nearly every other organism increased IIS resulted in a …
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Influence of dietary nutrients on life history-related traits of black flies and mosquitoes
… (Diptera: Simuliidae) and female Anopheles stephensi (Diptera: Culicidae) on artificial nectar and honeydew. Paired choice experiments showed that the black flies forage more frequently from high calorie diets, which contained melezitose, or those diets that contained amino acids, …
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Two Odorant-Binding Protein Genes in Mosquitoes: Comparative Genomics, Expression, and Function
… genome sequence of the African malaria mosquito, Anopheles gambiae, there has been a profound interest in the characterization and functional analyses of Obp genes in order to understand the molecular basis of mosquito host-seeking behavior. However, no direct evidence has been found for specific …
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Comparative genomics of chromosomal rearrangements in malaria mosquitoes
… a physical map for an Asian malaria vector, Anopheles stephensi, was created and compared with the maps of the major African malaria vectors A. gambiae and A. funestus No interchromosomal transposition was observed between A. gambiae and A. stephensi. Several cases of euchromatin and …
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Mosquito odor receptor gene targets to alter vector host choice
… consequences for the vectorial capacity of Anopheles mosquitoes. Mosquitoes in the genus Anopheles vector the pathogens causing human malaria, which resulted in over 600,000 deaths in 2020 (WHO World malaria report 2021). Yet many species of Anopheles, including An. quadriannulatus, are …