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Showing 1 to 13 of 13 for “"Annulus fibrosus"”.

  1. A collagen based scaffold for the repair of annulus fibrosus defects

    Saad, Leonide C. (Leonide Camile), 1977-Massachusetts Institute of Technology2007

    … heal and often trigger faster degeneration. The annulus fibrosus (AF) defines the outer boundaries of the disc and provides the structural integrity of the IVD. The purpose of this thesis was to evaluate the regenerative potential of a collagen type II scaffold on standardized defects of the AF. …

    mit Repository record

  2. Extracellular Matrix Degradation and Mechanical Integrity of Degenerated Human Annulus Fibrosus from Surgical Specimens

    Salaam, MohammedGraduate Studies2026

    … and functional mechanical failure of the annulus fibrosus (AF) remains poorly defined in human tissue. The interlamellar matrix (ILM), which binds adjacent collagen lamellae via cross-bridges, is a key determinant of AF mechanical integrity, but whether its weakening is driven by aging, …

    calgary Repository record

  3. Investigation of immune modulating disc therapy approaches in a bovine annulus fibrosus organ culture model

    Ekkerlein, AndreasUniversität Ulm

    ulm-diss Repository record

  4. Tissue-Engineered Annulus Fibrosus Repair and Nucleus Pulposus Augmentation in Pre-Clinical Models of Intervertebral Disc Degeneration

    Sloan, StephenCornell University2020

    … degeneration is characterized by lesions in the annulus fibrosus (AF), the outer fibrous ring of the IVD, which allow nucleus pulposus (NP), the gelatinous core, to herniate and impinge on surrounding neurological structures. Current surgical treatment options are unable to effectively repair the …

    cornell Repository record

  5. Effects of collagen type on the behavior of annulus fibrosus cells from the canine intervertebral disc in collagen-glycosaminoglycan matrices

    Saad, Leonide C. (Leonide Camile), 1977-Massachusetts Institute of Technology2002

    Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2002.

    mit Repository record

  6. Polymer Composite Spinal Disc Implants

    Frost, Brody A.Virginia Tech2017

    … this research study was to create an artificial annulus fibrosus similar to that of the natural intervertebral disc, as well as find preliminary results for vertebral endplate connection and nucleus pulposus internal pressure, for the correction of disc degeneration in the spine. The three-part …

    vt Repository record

  7. Effects of high intensity focused ultrasound on the intervertebral disc

    Persson, Johan KDepartment of Orthopaedics, Lund University2006

    … be found. The attenuation coefficient in bovine annulus fibrosus was found to be in the range of 1.1 to 1.3 dB cm-1 MHz-1 and the absorption coefficient 0.4 to 0.7 dB cm-1 MHz-1, which is approximately half of the attenuation coefficient. This indicates that a significant proportion of the …

    lund Repository record

  8. THE SYNTHESIS AND CHARACTERIZATION OF DUAL-MODIFIED CARBOXYMETHYLCELLULOSE FOR BIOADHESIVE APPLICATIONS

    Bernard, Fabrice2017

    … groups that could potentially be used as an annulus fibrosus sealant or as a supplement to existing wound closure materials. After modification, the polymer was characterized via NMR spectroscopy, Schiff’s base reaction, and size exclusion chromatography with multi-angle light scattering …

    cuny Repository record

  9. Mechanisms for regenerative intervertebral disc healing during early growth in mice

    D'Erminio, Danielle N2023

    <p>Annulus Fibrosus (AF) defects of intervertebral discs (IVDs) cause painful disability, for example when herniated tissue compresses against adjacent nerves. Discectomy, the current standard of treatment to address herniation, does not repair AF defects and can result in re-herniation and …

    cuny Repository record

  10. A collagen-GAG matrix for the growth of intervertebral disc tissue

    Hastreiter, Dawn (Dawn Marie), 1973-Massachusetts Institute of Technology2002

    … (CG) matrix for the growth of IVD annulus fibrosus (AF) tissue in vitro in varied culture environments and in an in vivo experiment as an implant for defects in the AF. Five experiments were performed. The first component involved the manufacture and characterization of the CG …

    mit Repository record

  11. Cellular And Mechano-Active Material Approaches To Improve Disc Repair After Herniation

    Peredo Nery, Ana Paula2022

    … (NP) core is surrounded circumferentially by the annulus fibrosus (AF), which together transmit loads to adjacent vertebra. Although this specialized structure evolved over millennia, the disc failed to develop mechanisms for self-repair. Instead, cell apoptosis and inflammation after injury lead …

    penn Repository record

  12. Mechanics of biomimetic materials for tissue engineering of the intervertebral disc

    Strange, Daniel Geoffrey TylerUniversity of Cambridge2013

    Tissue engineering offers a paradigm shift in the treatment of back pain. Engineered intervertebral discs could replace degenerated tissue and overcome the limitations of current treatments that disrupt the biomechanics of the spine. New materials, which exhibit sophisticated mechanical responses, …

    cambridge Repository record

  13. Investigating the Role of TRPV4 as a Mechanoreceptor in the Intervertebral Disc

    Shelton, Taylor Dominick SpenceThe University of Western Ontario2023

    Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4) is a cell membrane Ca2+ channel that regulates intracellular calcium levels in response to mechanical stimuli. Recent studies have demonstrated that TRPV4 is required for the induction of extracellular gene expression in …

    uwo Repository record