Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Ankyrin-G"”.
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Gene therapy for axon regeneration
… knockout of the cytoskeletal scaffolding protein Ankyrin-G. Two genetic tools were made and tested to knockout Ankyrin-G: (1) a short hairpin RNA, and (2) a dual promoter AAV viral vector that drives the expression of a CRISPR-associated endonuclease 9 from Staphylococcus aures and one guide RNA …
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Converging roles of neurodevelopment and Wnt signaling in neuropsychiatric disorders
… that bipolar disorder risk gene Ank3 (ankyrin-G) plays a crucial role in cortical neurogenesis through regulation of subcellular localization of [beta]-catenin, which is an essential component of Wnt signaling. Finally, the effects of brain-specific deletion of BcI9 on brain development …
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Regulation of the FGF14:Nav Interactome by a GSK-3 Centered Pathway
… with accessory and regulatory proteins including ankyrin-G, β-IV-spectrin, neurofascin, and intracellular fibroblast growth factors (iFGFs, FGF11-14). Dysregulation of the sodium channel complex is associated with a panorama of psychiatric disorders in both animal models as well as human …
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Anti-GD1a antibody targeted disruption of the node of Ranvier in a mouse model of acute motor axonal neuropathy
… including voltage gated sodium channel and ankyrin G. This is indicative of targeted injury to this region of the distal axon in an acute model. The loss of nodal protein staining is associated with the activation of complement and the Ca2+-dependent protease calpain as determined by the …
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CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
Over the past decade, growing evidence indicates that adult neurogenesis (the production of functionally mature neurons from progenitor cells in the adult mammalian brain) is linked to the etiology of many neurodegenerative and psychiatric disorders. Studies have shown that neurogenesis is clearly …