Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Anisomycin"”.
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Formation of caspase activating complexes and activation of caspase-12 during apoptosis in AKR-2B mouse fibroblasts
… durch Entzug des Serums oder Behandlung mit Anisomycin induziert werden. Der Zelltod zeigt zwar die für die Apoptose typischen morphologischen Veränderungen der Zelle wie Zellfragmentierung und Chromatinkondensation jedoch fehlen andere apoptotische Charakteristika, wie die oligonukleosomale …
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Protein Synthesis Inhibitors Impair Memory by Disrupting Release of Neurotransmitters Important for Memory Modulation
… using two protein synthesis inhibitors, anisomycin, a non-selective protein synthesis inhibitor, and CREB antisense, which impairs CREB-mediated gene transcription. At doses commonly used in the literature, both drugs reliably impaired memory when infused into the hippocampus and …
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Inhibition of Margination and Diapedesis of Neutrophils by Protein Synthesis Blockade
… inhibitors, a combination of puromycin and anisomycin. Our strategy, if fine-tuned, could form the basis of a new clinical strategy for the prevention of ARDS.
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Synthese und Photochemie von photoaktivierbaren Biomolekülen
… den Proteinsyntheseinhibitoren Emetin und Anisomycin, dem Protonophor CCCP und dem Riechstoff Bourgeonal hergestellt. Zur Synthese dieser caged Verbindungen wurden sowohl bekannte als auch verschiedene im Rahmen dieser Arbeit neu entwickelte photolabile Schutzgruppen mit einem …
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The role of purinergic receptors in the modulation of JNK signalling endothelial and cancer cells
… was cytokine specific, as neither sorbitol nor anisomycin dependent JNK activity was affected. Furthermore, ATP altered neither cytokine mediated p38 MAPK nor NF-κB signalling, indicating that the effect was pathway specific. In order to identify the P2YR involved, HUVECs were pre-treated with …
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Characterization of the prostacyclinIP receptor system in the rat kidney: Implications for diabetic nephropathy
… respectively. CCP-CAMP was also diminished by anisomycin, a MAPK activator. PGI2 synthesis is dependent on cyclooxygenase (COX) and PGI 2 synthase (PGIS). We show increased COX-1 and -2 in the medulla of STZ rats, as well as HG-IMCD. Only COX-2 was elevated in HG-MG. While PGE 2 synthase was …
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MEK1 binds βarrestin1 directly, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
… be affected by challenge with the PDE inhibitor, anisomycin, and cAMP elevating agonists forskolin (Fsk) and isobutylmethylxanthine (IBMX). RACK1, another PDE4D5 binding partner, mediates and initiates cell migration in many cell types and affects the activity of the c-Jun NH2-terminal kinase …
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The role of the chromatin protein HMGN3 in cytokine induced gene expression
… of a previous study that showed HMGN1 inhibits anisomycin-stimulated fosB transcription. Taken together, this shows that HMGN3 fine-tunes TNFα-induced gene expression, and suggests it may be necessary to remove HMGN3 from the mCCL1 gene in order to get efficient transcription. mCCL1 is known to …
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Screening for novel compounds produced by Actinobacteria and Gardnerella vaginalis that impact HIV-1 infection
… D, Valinomycin, Antimycin, Puromycin and Anisomycin. As some commercial antibiotics have been shown to have antiviral activity, we tested the ability of the antimicrobials to inhibit PSV infection. However, we were unable to determine accurate IC50 values due to the cytotoxicity of all the …
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Immunological investigations into synaptic plasticity
… the presence of the protein synthesis inhibitor, anisomycin. These results are discussed in the context of current models of synaptic plasticity.
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JNK regulates Fas receptor mediated apoptosis in prostate cancer cell lines
… Fas receptor activation alone. Co-administering anisomycin, a JNK agonist, greatly enhances the ability of DU 145 cells to undergo apoptosis by increasing the rate of Caspase 8 cleavage. We also investigated the role of endogenous JNK activity in Fas receptor mediated.
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Cloning and functional characterization of novel genes expressed preferentially in the human retina
… protein synthesis with antibiotics puromycin and anisomycin in human cell lines A-RPE 19 and Y79. Our analysis resulted in an increase of the PTC containing transcript and a decrease of the ABCC5 transcript. Conversely, the amount of both transcripts (SV1 and ABCC5) returned to pre-treatment …
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Aktivierung von Caspasen in AKR-2B Mausfibroblasten
In der vorliegenden Arbeit konnte die essentielle Beteiligung von Caspasen im Zelltodmodell der AKR 2B-Mausfibroblasten nachgewiesen und ihre Aktivitäten charakterisiert werden. AKR 2B-Mausfibroblasten stellen eine subklonierte und gut charakterisierte Zellinie dar, in der durch Entzug des Serums …