Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Animal study"”.
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Comparison of progression of diffuse axonal injury with histology and diffusion tensor imaging
… fiber tracts. To date, only one correlative animal study has been carried out to investigate the DTI relationship to TAI, and it has reported a relationship between DTI changes and TAI. No other animal study has validated the correlation between DTI and TAI. Therefore, this study is the …
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Human intestinal microbiota and metabolites they produce in relation to host health
… used in both the manufacture of yoghurt and an animal study. In total, 38 B. longum strains, obtained from infants and adults, were assessed in vitro for the selected probiotic traits using a combined phenotypic and molecular approach. Differentiation of the 38 strains using amplified ribosomal …
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Development of Virus-like particles (VLPs) Based Vaccines Against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV)
… of the polymeric nature of VLP. The first animal study evaluated the efficacy of 4 VLP based vaccine candidates against PRRSV in mice. These 4 vaccines incorporated 2 B-cell epitopes (61QAAIEVYEPGRS72 and 89ELGFVVPPGLSS100) and 2 T-cell epitopes (117LAALICFVIRLAKNC131 and …
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Risk-Sensitive Foraging in Humans Budgeting Time: Correlated with Real-World Financial Situation
… theory has been studied extensively in non-human animals. Using models developed through animal-study, researchers have recently begun to examine how humans make decisions with regard to resource-expenditure. Using a computer-based task, the proposed study investigated risk-sensitive …
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Risk-Sensitive Foraging in Humans Budgeting Time: Correlated with Real-World Financial Situation
… theory has been studied extensively in non-human animals. Using models developed through animal-study, researchers have recently begun to examine how humans make decisions with regard to resource-expenditure. Using a computer-based task, the proposed study investigated risk-sensitive …
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The nature of leukocytic response to mouse mammary tumor implants in C3H/HeJ mice with and without anticoagulation
… is a common form of cancer used for experimental animal study. This investigation was designed to study the nature of leukocytic response to mouse mammary tumor implants in C3H/HeJ mice with and without anticoagulants. The main thrust of the research was in three areas: first, to develop a …
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Development of an Artificial Meniscus Implant
… as a meniscus replacement. To validate this, an animal study was designed to access durability as well as the biocompatibility and chondroprotection of the implant. A sheep shaped implant was designed for this test and cadaveric work was performed to provide a final design with proper fit and …
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Development of a Non-Contact Fluorescence Tomography System with Appropriate Reconstruction Techniques
… imaging devices. It is mainly concerned with studying the effects of prototype drugs in small animals, following day by day the evolution of the disease in vivo. Amongst the imaging techniques available, fluorescence based imaging is very popular due to the simplicity of the experimental …
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Application of a High‑Resolution Computed Radiography System in Detecting an Iodinated X‑ray Contrast Agent: Small Animal Phantom Study
… contrast agent, in a phantom mimicking small animal tumor model.</p> <p>The first phase of the project was dedicated to a comprehensive assessment of CR image quality by measuring presampled Modulation Transfer Function (MTF), Noise Power Spectrum (NPS), Relative Standard Deviation of Noise …
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Effect of Soy Protein, Isoflavones and Methionine Supplementation on Lipid Metabolism
… where the effect was more pronounced. A second study was conducted to evaluate dietary isoflavones and methionine concentrations on gerbils. Results from these studies indicated that total cholesterol levels were significantly lower (p < 0.05) in the soy-fed group, compared to casein-fed group, …
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Small molecule kaempferol, a novel regulator of glucose homeostasis in diabetes
… insulin-deficient diabetic mice. For the first animal study, kaempferol was supplemented in the diet to determine whether it can prevent insulin resistance and hyperglycemia in high fat (HF) diet-induced obese mice or STZ-induced obese diabetic mice. For the second animal study, kaempferol was …
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Tissue engineering of co-cultured skin substitutes using biocomposite membranes based on collagen and polycaprolactone
… assay. The following in vivo animal study on athymic mice revealed early complete wound healing in 10 days and good integration of co-cultured skin substitutes with adjacent mice skin structures. Thus the co-cultured skin substitutes based on 1:20 collagen: PCL biocomposite …
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Neuroprotective Effect of Human Mesenchymal Stem Cell on Dopaminergic Neurons by Anti-inflammatory Action
… role in the pathogenesis of PD. The present study was to evaluate effect of human bone marrow-derived mesenchymal stem cell (hMSCs) on modulation of neuroinflammation. We used lipopolysaccharide (LPS)-induced in vitro and in vivo inflammation models to investigate whether hMSCs have a …
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The Role of Arginine Vasopressin Receptor 2 in Microvascular Hyperpermeability During Severe Sepsis and Septic Shock
… leakage. Thus, the overall goal of the current study was to investigate the most important mechanisms of vascular leakage during severe sepsis and propose a novel therapeutic strategy for this condition. Arginine vasopressin (AVP), a hypothalamic hormone, has been used exogenously in sepsis to …
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Needle-free interstitial fluid acquisition using a Lorentz-force actuated jet injector
… novel ISF acquisition method. A micro-CT imaging study identifies the magnitudes of injected jet speed that will influence injectate delivery to specific skin layers. A histology study highlights the differences in tissue damage between needle injections and jet injections. A new tool for …
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The Characterization of Osteocyte Apoptosis in a Mouse Model of Orthodontic Tooth Movement
… during orthodontic tooth movement (OTM). In this study, we wanted to further investigate its occurrence and localization.</p> <p>Method: Sixteen 10-12 week old male CD1 mice were loaded with NiTi springs between the right first maxillary molar and incisor delivering 10-12g of force. Left …
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Enhancing the use of opioids in pain management: antinociceptive potentiation with opioid agonist/antagonist combinations.
… approach that has produced promising findings in animal studies and some clinical reports is the combination of an opioid agonist and "ultra-low" (nanomole) doses of an opioid antagonist. A recent animal study reported that antinociception may be significantly enhanced with the combination of the …
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Autoimmune Responses to Atherosclerotic Lipids: A Study In Murine Models of Atherosclerosis and Obesity
… signal transduction In the first part of this study, oxidative phospholipids were identified and characterized as potential autoantigen for CD1d-restricted T cells. Derived from phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine by oxidization, …
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Complexation of trivalent lanthanides by three diphosphonate ligands in the blood plasma
… citrate for complexation of Ho(III). For this study three diphosphonate ligands applied in radiation imaging of bone or nonradiative treatment of osteoporosis were chosen. They are APD (1-hydroxy-3-aminopropylidene- diphosphonic acid), MDP (methylenediphosphonic acid) and HEDP (1- …
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The Interaction of Obesity and Age and their effect on Adipose Tissue Metabolism in the Mouse
… a comprehensive lipidomic and transcriptomic study of white adipose tissue in mice that become obese either through genetic modification (ob/ob genotype), diet (high-fat diet) or a combination of the two across the life course. Specifically, I demonstrated that the changes in triglyceride …
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