Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Animal imaging"”.
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Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging
… a single source and detector pair for small animal imaging. In our system, the intensity of laser source is modulated to produce a diffuse photon density wave in the tissue. The phase of the diffuse photon density wave is measured by comparing the reference signal with the signal from tissue …
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Development of novel emission tomography system
In recent years, small animals, such as mice and rats, have been widely used as subjects of study in biomedical research while molecular biology and imaging techniques open new opportunities to investigate disease model. With the help of medical imaging techniques, researchers can investigate …
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Imaging and Measuring Cerebral Metabolism in the Healthy Brain and Changes Following Inflammation
… has focused on basic biology, pre-clinical large animal imaging, clinical sodium imaging in Multiple Sclerosis, and a physiological first in man study of the healthy brain with hyperpolarised [1-13C] pyruvate.
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Deterministic Barcoding of Neuron Identities through Multicolor Fluorescent Markers in C. elegans
… challenging. In this work, we achieve live animal imaging and cell identification by generating a multicolored fluorescent map of different neurons in C. elegans. We take advantage of neuron type-specific promoters to construct transgenes that label each neuron type with unique red, green, …
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Acoustic scattering by axisymmetric finite-length bodies with application to fish : measurement and modeling
… than one significant scattering feature in the animaL. Imaging technologies used to exactly measure the morphology of the scattering features of fish include very highresolution Phase Contrast X-rays (PCX) and Computerized Tomography (CT) scans, which are used for morphological evaluation and …
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Measurement of retinal vascular permeability in a rat model using spectroscopic optical coherence tomography
… non-contact, noninvasive, cross-sectional imaging of the retina and anterior eye in real time, has dramatically improved in its resolution and speed in the recent years. In addition to the advancement in hardware, different OCT methods for functional measurements, such as Doppler OCT for …
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Advanced Projection Ultrasound Imaging with CMOS-based Sensor Array: Development, Characterization, and Potential Medical Applications
… has become one of the most widely used medical imaging device as a diagnostic tool or an image guider for surgical intervention because of its high portability, non-ionization, non-invasiveness and low cost. Although continuous improvements in commercial equipments have been underway for many …
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Sviluppo di un tomografo multi-energy per lo studio pre-clinico di nuove metodiche diagnostiche finalizzate al riconoscimento precoce della patologia tumorale
A new multi-energy CT for small animals is being developed at the Physics Department of the University of Bologna, Italy. The system makes use of a set of quasi-monochromatic X-ray beams, with energy tunable in a range from 26 KeV to 72 KeV. These beams are produced by Bragg diffraction on a Highly …
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Examining Mechanisms and Functional Significance of Adiponectin Stimulated Autophagy in Cardiometabolic Diseases
… of autophagy impairments. With an advanced live-animal imaging system, a lower autophagy activity was observed in adiponectin knockout mice hearts after stresses. Cell culture experiments further validated that adiponectin directly stimulated autophagy flux and protected cardiomyocytes from cell …
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Image Reconstruction of the Speed of Sound and Initial Pressure Distributions in Ultrasound Computed Tomography and Photoacoustic Computed Tomography
… computed tomography (PACT) are two emerging imaging modalities that have a wide range of potential applications from pre-clinical small animal imaging to cancer screening in human subjects. USCT is typically employed to measure acoustic contrasts, including the speed of sound (SOS) …
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Methods and adaptations required to perform small-animal MRI scanning using a large bore clinical MRI
Small-animal imaging has been widely implemented to study succession of disease, therapeutic treatments and the effects of environmental insults. The gold standard noninvasive technique for following progression of heart failure in small-animal models is magnetic resonance imaging (MRI). The aim of …
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Integración de imágenes biomédicas : técnicas basadas en teoría de la información
… multimodales (anatómicos y funcionales) de animales de laboratorio mediante técnicas basadas en teoría de la información. Se realiza un análisis de la influencia de los parámetros del algoritmo de registro, así como una validación sistemática de los resultados. Para poder evaluar el …
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Dynamic Contrast-Enhanced MR Microscopy: Functional Imaging in Preclinical Models of Cancer
… (DCE) MRI has been widely used as a quantitative imaging method for monitoring tumor response to therapy. The pharmacokinetic parameters derived from this technique have been used in more than 100 phase I trials and investigator led studies. The simultaneous challenges of increasing the temporal …
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Next generation multi-color carbon dots: A comprehensive understanding of their photophysical properties and subsequent use for biomedical applications
… of biomedical application ranging from bioimaging, cell labeling, drug delivery, and sensors. For synthesizing these CDs, multitude of different raw materials and synthetic approaches have been reported. The reported raw materials utilized range from natural products such as glucose, citric …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… Concomitantly, we developed a lung cancer animal-imaging model by subcutaneous xenograft and orthotopic lung implantation of NSCLC adenocarcinoma cells (A549) that were genetically modified with the human sodium iodide symporter gene (hNIS; SLC5A5) for the purpose of tumor imaging. Lung …
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Non-invasive in vivo ultrasound temperature estimation
… its safety and efficacy.The advent of diagnostic imaging tools for guidance of thermal therapy was a key factor in the clinical acceptance of these minimally invasive or noninvasive methods. More recently, ultrasound and magnetic resonance (MR) thermography techniques have been proposed for …
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Sistemas tomográficos multimodalidad para animales de laboratorio
… evaluación del rendimiento de tomógrafos PET de animales de laboratorio. Para caracterizar el sistema SPECT, al no existir un protocolo estándar para pequeño animal se ha seguido un protocolo similar al utilizado para sistemas de humanos y se han realizado estudios in vivo con roedores y con …
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Real-time membrane puncture detection using force sensors for micro-injections in phantoms
… target will squander research time, experimental animals and other resources. An ultrasound-guided robot developed at Robarts Research Institute was revised to implement closed-loop force feedback to compensate for tissue deformation during micro-interventions. Force sensors can detect puncture …
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Measurement of The Vascular Input Function In Mice For Dce-Mri
… is an important technique in the study of small animal cancer models because its sensitivity to vascular changes opens the possibility of quantitative assessment of early therapeutic response. However, extraction of physiologically descriptive parameters from DCE-MRI data relies upon measurement …
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Development of a Three-Dimensional Image-Guided Needle Positioning System for Small Animal Interventions
… needle positioning techniques for small animal microinjections are fraught with issues of repeatability and targeting accuracy. To improve the outcomes of these interventions a small animal needle positioning system guided by micro-computed tomography (micro-CT) imaging was developed. A …
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