Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Animal development"”.
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The extracellular matrix of the nematode Caenorhabditis elegans : a model to study the role of cell-matrix interaction in animal development.
… the role of extracellular matrix (ECM) in animal development. During development, cells have to gain positional or environmental information either from other cells or their environment. The ECM is located in outside of tissue cells and provide environmental information to lead the proper …
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Components of the Ubiquitin Proteasome System are Required for the Nonapoptotic Death of the C. Elegans Linker Cell
… tissue sculpting and morphogenesis during animal development. Many developmental cell-culling events cannot be accounted for solely by caspase-dependent apoptosis, yet, alternate pathways are poorly understood. Direct evidence that caspase-independent non-apoptotic cell death pathways …
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Genetic regulation of cell extrusion in caenorhabditis elegans
Programmed elimination of cells occurs during animal development and homeostasis to maintain appropriate cell numbers. One evolutionarily conserved method by which organisms eliminate cells in a programmed manner is by cell-autonomous activation of the caspase-mediated apoptosis pathway, which …
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Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development
… earlier, syncytial stages of Drosophila embryo development. Btsz was required for the formation of stable pseudo-cleavage furrows that prevented spindle collisions and nuclear fallout prior to cellularization. While previous studies focused on Btsz isoforms containing the Moesin Binding Domain …
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Identification and Characterization of a New E1 That Activates Ubiquitin and FAT10
… that E1-L2 is essential for early embryonic development. Since the FAT10-deficient mice develop normally, it is likely that specific ubiquitination reactions catalyzed by E1-L2 play an important role in animal development.
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The role of Ultrabithorax negative autoregulation in Drosophila melanogaster
One of the more striking features of animal development is that a limited set of developmental control genes is used repeatedly, in different contexts (within an organism and between species), to form different structures. To achieve this, gene regulatory networks must be versatile. Transcription …
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The localisation and role of Sidekick at apical vertices in Drosophila epithelial morphogenesis
During animal development, epithelial tissues undergo morphogenesis in order to build tissues, organs and body structure. A key driving force in epithelial morphogenesis is cell rearrangement, which results from the remodelling of cell-cell contacts. In epithelia, cell-cell contacts are connected …
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Characterizing the Nuclear Function of the Cell Adhesion Molecule Fat and Chromatin Regulation by the Inner Nuclear Membrane Protein Speg
… formation and cell metabolism are fundamental to animal development. Coordination of these aspects requires elegant signal transduction systems. In Drosophila, fat (ft) encodes an enormous atypical cadherin that is important for such coordination. Ft functions at the cell surface, regulating …
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Cellular-level mechanisms of polarity and their role in plant growth
… cell polarity fields are essential for plant and animal development. Several models have been proposed for how these cell polarity fields are established. However, it remains unclear how different models are related to each other and how coordinated cell polarity fields are generated. Here, I …
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Concentration-dependent Splicing through Suboptimal Motifs Enables Waves of Gene Regulation in Neuronal Development
… contributor to organismal complexity in animals. The Rbfox family of splicing factors regulates alternative splicing during animal development and in disease, impacting thousands of exons in the maturing brain, heart, and muscle. Although it is well established that Rbfox binds to the RNA …
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The genetics of the sexually dimorphic deaths of the C. elegans CEM neutrons
… of this endogenous death program is essential to animal development and to the prevention of disease. To better understand how individual cells are developmentally specified to die, I studied the survival decision of a single cell type in the nematode Caenorhabditis elegans, the CEM neurons. The …
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The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability
… known roles for Perlecan and other HSPGs in animal development, with a focus on their functions within the nervous system. In Chapter 2, I describe how loss of Drosophila Perlecan causes alterations in the axonal cytoskeleton and breakage of axons, followed by synaptic retraction of …
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Genetic and Molecular Characterization of Programmed Cell Death in the C.elegans Tail-Spike Cell
… the timing of cell death onset during animal development.</p>
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Components Required for the Death and Degradation of the Linker Cell in C. Elegans
… cell death (PCD) is an important process in the development of multicellular organisms. Apoptosis, a form of PCD characterized morphologically by chromatin condensation, membrane blebbing, and cytoplasm compaction, and molecularly by the activation of caspase proteases, has been extensively …
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Formation of morphogen gradients
… are signaling molecules that play a key role in animal development. They spread from a restricted source into an adjacent target tissue forming a concentration gradient. The fate of cells in the target tissue is determined by the local concentration of such morphogens. Morphogen transport through …
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Synthetic morphogenesis : space, time, and deformation
… we understand the principles of our origins { animal embryonic development - by re-engineering it in the laboratory? I investigate, from an engineer's perspective, some of problems that arise in developing geometric form in a deformable substrate. More abstractly, I attack the problem of …
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Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development
… motility is essential for many aspects of normal animal development. However, little is known about how cell motility and associated changes in cell shape are regulated in the context of epithelial tissue patterning. This study investigates the cell motility of developing ommatidia, a process …
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Studies of programmed cell death in the nematode caenorhabditis elegans
… process that plays critical roles in normal animal development and has been extensively studied in C. elegans. During programmed cell death, caspases are activated in the dying cell. The cell corpse is engulfed by a neighboring cell and degraded. Almost all cell deaths in C. elegans are …
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Regulatory consequences of mRNA Poly(A)-Tail length changes
… of translational efficiency during early animal development and discovered a broadly conserved developmental switch in translational control. During the tail-length regulatory regime of the early embryo, a protein or microRNA might regulate translation by changing the poly(A)-tail length …
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Dynamics of Germ Cell Specific Stable Transcriptional Complexes in Xenopus Oocytes
Early animal development depends largely on the activation/expression of genes, and this often depends on the binding of transcription factors to genomic DNA sequences on which they act. This is particularly true of genes that determine cell fate; for example, Asc1-1 leads to neural differentiation …
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