Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"Animal Testing"”.
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Lost in technification : Uncovering the latent clash of societal values in Dutch public policy discourse on animal-testing alternatives
Contains fulltext : 151524.pdf (Publisher’s version ) (Open Access)
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Analysis of Virtual Control Groups and Inter-species Concordance using Preclinical Toxicity Data
… In line with the US EPA’s “Toxicity Testing in the 21st Century: A Vision and Strategy” and the Replacement, Refinement, and Reduction (3Rs) goals for animals in toxicity testing, the current two species preclinical testing paradigm for small molecules outlined in ICH M3 (R2) is under …
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Development of an analytical method to derive hydrophobicity parameters for use as descriptors for the prediction of the environmental and human health risk of chemicals
… this was determined through the use of animal testing. However, there is an increased need to develop alternatives to animal testing for the determination of toxicity due to ethical and legislative reasons. One approach to replacing the use of animals is the application of computational …
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THE BIO-MOLECULAR ANALYSIS OF TITANIUM DIOXIDE NANOPARTICLES EXPOSURE ON CARDIOMYOCYTES
… the increasing large number of NPs required for testing has led to the need for new alternative testing strategies via computational means to replace the costly and laborious animal testing. Yet, such testing requires the understanding and identification of relevant safety biological endpoints to …
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Ecotoxicogenomic New Approach Methods for Screening Development in Danio rerio
… resource-intensive and often involve extensive animal testing, are not feasible for assessing the vast number of chemicals in use today. This includes not only new chemicals submitted for authorization, but also chemicals that require re-evaluation. This thesis contributes to addressing the need …
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An investigation of blast wave transmission through rodent simulants
… post-mortem. There are many drawbacks to live animal testing that make a surrogate test article an attractive prospect. The goals of the current work are to 1.) develop a bio-fidelic instrumented surrogate rat model for use in blast testing and 2.) validate a computational model’s ability to …
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Hybrid Microfluidic Sensing Platforms for Cancer Cell Study: Recent Advances and Future Prospects
… to study cancerous tumor invasion and substitute animal testing. Furthermore, many efforts have been made by incorporating sensing instruments with these microfluidic systems to monitor cellular/organ activities continuously and quantitively evaluate their behaviour and response to various …
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Entwicklung eines Hepatozytenbioreaktors zur Anwendung in der Toxikologie und Metabolismusforschung
New approaches for in vitro testing of hepato-mediated toxicity are undertaken to offer alternatives to in vivo animal testing. The described bioassay for hepato-mediated toxicity testing is based on a small scale hepatocyte-bioreactor with pig hepatocytes connected to a silicon sensor based …
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Magnetostatic Modeling for Microfluidic Device Design
… prior to in vitro experimentation, animal testing, and finally clinical testing. To better understand and unleash this technology, COMSOL®, which is a finite element analysis and multiphysics simulation software, has recently been used to model superparamagnetic particles in several …
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Machine learning in predictive toxicology: investigating developmental and reproductive toxicity with transfer learning
… In the field of predictive toxicology, with animal testing being phased out in some sectors, there is an urgent need for alternative methods for determining toxicity. An *in silico* method such as machine learning is one such popular choice given that the results can be obtained quickly with …
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THE INTEGRATED USE OF PHYSICOCHEMICAL AND IN VITRO DATA FOR PREDICTING CHEMICAL TOXICITY
… the toxicological hazard of chemicals in animals. This was achieved in two stages: firstly, by developing two types of model for acute dermal and ocular toxicity - structure-activity relationships (SARs) based on easily calculated physicochemical properties, and prediction models (PMs) …
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Pressure versus impulse graph for blast-induced traumatic brain injury and correlation to observable blast injuries
… of the signature wounds in current conflicts. Animal studies have been conducted to understand the mechanisms in the brain and a pressure versus time graph has been produced. However, the role of impulse in bTBIs has not been thoroughly investigated for animals or human beings.</p><p>This …
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Design optimization of oxygenated fluid pump
… be modified to improve its performance. Further testing is required to tune the control system and ensure that the flow rate is accurate to ±10%. The pump is mostly being used as a research tool in order to run tests that will help characterize the fluid and later can be used for small and large …
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Integration of Data Quality, Kinetics and Mechanistic Modelling into Toxicological Assessment of Cosmetic Ingredients
… are based on in vivo data. Due to the ban on animal testing of cosmetic ingredients in the European Union, alternative approaches, such as in vitro and in silico tests, have become more prevalent. In this thesis existing non-testing approaches (i.e. studies without additional experiments) have …
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Development of in silico models for the prediction of toxicity incorporating ADME information
… problem. Additionally, there is a need to reduce animal testing for toxicological risk assessment for ethical and financial reasons. In silico methods offer an alternative that can address these challenges. A variety of computational approaches have been developed in the last two decades, these …
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Mathematical modelling of drug metabolism : using <em>in silico</em> techniques to investigate the cytochrome P450 enzyme system in hepatic reductase null mice
… costs and once set up can be used to replace animal testing for drugs. As such modelling techniques need to be developed to reduce dependence on animals for validation of pharmacological efficacy. The work within this thesis shows that computational methods can be used to model biological and …
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Development of Artificial Intelligence-based In-Silico Toxicity Models. Data Quality Analysis and Model Performance Enhancement through Data Generation.
… process. The need for reducing dependence on animal testing has led to an increasing interest in alternative methods such as in silico modelling. The QSAR (Quantitative Structure Activity Relationship)-based models are already in use for predicting physicochemical properties, environmental …
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Development of Artificial Intelligence-based In-Silico Toxicity Models. Data Quality Analysis and Model Performance Enhancement through Data Generation
… process. The need for reducing dependence on animal testing has led to an increasing interest in alternative methods such as in silico modelling. The QSAR (Quantitative Structure Activity Relationship)-based models are already in use for predicting physicochemical properties, environmental …
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UNDERSTANDING CONDITIONAL MODES OF ACTIONS IN CHEMICAL-INDUCED TOXICITY USING RULE MODELS
It is estimated that 115 million animals are used in experimental testing each year. Hence, shifting efforts toward alternative methods for toxicity assessment is essential. However, slow regulatory acceptance of new approaches is governed by knowledge gaps in toxicity modes of action. In this …
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Analysis and mitigation of mechanical shock effects on high speed planing boats
… chronic injury are investigated. Past human and animal testing is reviewed, along with information on the transmissibility and mechanical impedance of the human body. Information of this type, along with other injury data compilation studies, have contributed to existing injury prediction. Third, …
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