Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 681 for “"Animal Physiology"”.
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Transgene-free strategies for wireless control of animal physiology using magnetite nanoparticles
… are emerging therapies designed to control human physiology using electrically actuated stimuli instead of drugs. The most famous example is deep brain stimulation (DBS) for Parkinson's disease, in which electrodes are used to control brain activity and prevent tremors. An idealized version of …
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Regulation of C. elegans behavior and physiology by the hypoxia-response pathway
… environmental hypoxia is broadly conserved in animals. The key mediator of this response is the transcription factor HIF (hypoxia-inducible factor), which is active only in hypoxia due to the function of its negative regulators, the prolyl hydroxylase EGLN and the E3 ubiquitin ligase complex …
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Influences of nutrition and pathogenicity from a microbial diet on immunity and longevity in Caenorhabditis elegans
… with the environment play a critical role in animal physiology and evolution. Animals alter their cellular functions and organismal behavior to maximize survival in a given setting, or make the decision to seek out a new environment that is more compatible with life. Responses to external …
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Oxygen, the invisible orchestrator of metabolism and disease : a focus on mitochondrial And peroxisomal dysfunction
… levels have far-reaching consequences on human physiology and health. Mitochondrial disorders are the most common inborn errors of metabolism, affecting approximately 1 in 5000 live births. Patients can present in infancy or adulthood with symptoms affecting multiple organ systems including …
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Improvement and establishment of the tTA-dependent inducible system in the mouse brain
… a more precise analysis of gene functions on animal physiology and behaviour. For efficient expression of tTA in the mouse, the coding sequence of the htTA was altered concerning mammalian codon usage, putative splicing signals, CG dinucleotide content, and toxicity of the transactivation …
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Regulation of Adaptive and Innate Immunity by the Circadian Transcription Factor NFIL3
The day-night cycle has a profound impact on animal physiology, which has been shown to be mediated by an intracellular timing system called the circadian clock. However, little is known about whether and how the day-night cycle and the circadian clock influence host immunity. Here, I show that the …
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Genetic analysis of the neuronal integrated stress response in developmental plasticity and organismal physiology of C. elegans
… how environmental cues influence organismal physiology through evolutionarily conserved neuroendocrine signaling mechanisms. My genetic characterization of the previously isolated daf-28(sa191) mutant that enters dauer constitutively has revealed cell-nonautonomous roles of conserved stress …
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Exploring circadian rhythms, food intake, and their interactions in marine invertebrates
… are critical and interconnected components of animal physiology. Metabolic inputs like time of feeding modulate circadian clocks and behavioral and molecular rhythms. In turn, circadian clocks regulate metabolic processes, allowing animals to optimize energy usage on daily timescales. On longer …
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Exploring circadian rhythms, food intake, and their interactions in marine invertebrates
… are critical and interconnected components of animal physiology. Metabolic inputs like time of feeding modulate circadian clocks and behavioral and molecular rhythms. In turn, circadian clocks regulate metabolic processes, allowing animals to optimize energy usage on daily timescales. On longer …
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Structural insights into the GABAA receptor gating cycle
… (pLGICs) that control multiple aspects of animal physiology, including the rapid inhibitory neurotransmission within the vertebrate central nervous system. They activate and desensitize in a few milliseconds, which is a crucial requirement for accurate synaptic signalling. Such fast …
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Short Chain Fatty Acids Signaling through the G Protein-Coupled Receptor GPR41 in the Intestine.
… that inhabit the gastrointestinal tract of animals. The resident microflora modulate thephysiology of the gastrointestinal tract in several ways, from shaping the villi vasculature to regulation of epithelial cell proliferation and differentiation. Of more relevance to this study is the fact …
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Multimodal Imaging of Protein-Based Biomaterials for Delivering Chemo-Agent Cargo for Glioblastoma Treatment in a Murine Model
… understanding of tumor staging and its impact on animal physiology, particularly as it relates to luciferin uptake and BL signal kinetics. Changes in tumor microenvironment and vascular properties over time may significantly influence drug delivery and imaging outcomes, emphasizing the importance …
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THE RESPIRATORY RESPONSE OF TRPV1 KNOCKOUT MICE TO TRIGEMINAL IRRITANTS
The trigeminal nerve is composed of polymodal neurons which innervate the nasal cavity, nasopharynx, oral cavity and cornea. Trigeminal nociceptive fibers are stimulated by a wide variety of chemical irritants. However, the mechanism of stimulation is known for only a few compounds. TRPV1 channels, …
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Integrated modulation of sympathetic tone in the microcirculation by oxygen, adenosine, and nitric oxide
Despite a profound reduction in hemodynamic shear stress, a sustained release of endothelium-derived nitric oxide (NO) limits arteriolar constriction during periods of increased sympathetic nerve activity in the rat small intestine. In this project, we sought to test the hypothesis that adenosine, …
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Evidence for a systemic embryotoxic effect of early luteal regression in the ewe
Experiments were performed to determine if a short-lived corpus luteum was embryotoxic in ewes given supplemental progesterone and the route of transfer of embryotoxic products. Mated ewes were lutectomized or sham lutectomized on day 4 after estrus. Following surgery, ewes received saline or PGF …
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Developmental Effects of Cortisol on the Stress Response and Behaviour in Zebrafish
The objective of the study was to determine whether maternal stress affects early development in zebrafish (Danio rerio). The hypothesis was that maternal stress will lead to excess cortisol deposition in the embryos, and this will compromise the larval stress response and locomotor activity. …
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The Role of Calcium in the Mechanism of Muscle Fatigue in Intact, Single Muscle Fibres of Mice at Physiological Temperature
The purpose of this study was to investigate the role of Ca2+ in the mechanism of fatigue during repeated submaximal contractions. Intact, mouse single muscle fibres were fatigued at 32C with intermittent submaximal stimulation until 40% of initial force. A force-[Ca2+]m relationship was determined …
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The Effect Of Streptozotocin-induced Diabetes And Thyroid Hormone Alterations On Skeletal Muscle Contractile, Histochemical And Biochemical Properties
… 30, 50 or 75 ug/kg body weight of T3 to diabetic animals instigated a normal negative feedback response despite the diabetic state. These data would support the hypothesis that the alterations in thyroid hormone production observed in the diabetic state are a function of either an altered …
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The Function Of Sarcoplasmic Reticulum In The Aged Rat Heart
The purpose of this project was to study the effect of aging on the regulation of Ca{dollar}sp{lcub}2+{rcub}{dollar} by cardiac sarcoplasmic reticulum (SR) and its potential contribution to the age-related alterations in myocardial contractile performance in Fischer 344 rats.;In cardiac membranes …
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