Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Animal Modeling"”.
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Site-Specific Genome Engineering in Mouse Primary Fibroblasts
… very little has been accomplished in terms of animal modeling of these principles. The work described in this thesis seeks to address some of these issues in a reporter mouse model that we have developed to study genome engineering. With this model we have demonstrated gene correction of an …
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Site-Specific Genome Engineering in Mouse Primary Fibroblasts
… very little has been accomplished in terms of animal modeling of these principles. The work described in this thesis seeks to address some of these issues in a reporter mouse model that we have developed to study genome engineering. With this model we have demonstrated gene correction of an …
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Molecular Mechanism of Zipper Interacting Protein Kinase
… full length ZIPK. Future research that employs animal modeling as a tool to investigate ZIPK will be informed by the experiments that address the cellular localization of ZIPK.</p>
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Studies of Replication Repair Deficient Brain Tumorigenesis Using Mouse Modeling
Replication repair deficiency (RRD) is a pan-cancer mechanism caused by germline and/or somatically acquired deficiency in the replication repair machinery – DNA polymerase proofreading and the mismatch repair (MMR) system. Germline monoallelic (Lynch Syndrome, LS) or biallelic (Constitutional …
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Biochemical changes in animal models of fetal alcohol spectrum disorder
<p>Fetal alcohol spectrum disorder (FASD) is a completely preventable disease, that has profound effects on life-long health and function of the affected individual. Prevalence estimates of FASD in the United States indicate 33.5 per 1,000 live births are affected with this disorder (Roozen, 2016). …