Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Angiotensinogen"”.
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Evaluation of Metabolic Endpoints for Use as Biomarkers of Exposure to Environmental Estrogens and in Bioassays of Their Activity
These findings indicate that angiotensinogen and uterine complement C3 can serve as sensitive indicators of estrogenicity. Additionally, angiotensinogen has the potential to be a biomarker of exposure to estrogenic compounds because its measurement only requires a blood sample, while providing a …
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Prorenin, its maturation and the (pro)renin receptor
… to (pro)renin caused increased cleavage of angiotensinogen and stimulation of an intracellular signalling pathway. The aim of this thesis is to investigate the biology of prorenin, its maturation and the (pro)renin receptor.
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The Angiotensin Receptor (AT₁) Inhibitor, Losartan, Slows Post-Natal Thickening of the Left Ventricle
… AT, receptor. Immunohistochemical detection of angiotensinogen (AQ) in a parallel study of these hearts indicated increased levels in the LV during the first 24 post-natal hours. These results support a role for the cardiac RAS system in controlling LV wall thickness in mammalian heart.
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Solution structure and biochemistry of an intramembrane aspartyl protease (IAP)
… and cleavage sites of a fortuitous substrate, angiotensinogen, and Alzheimer disease linked C100 substrate, in detergent and bicelle conditions highlighted the importance of substrate-membrane, substrate-enzyme and enzyme-membrane interactions. Through structure-function analysis of a model IAP …
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Effect of Thyroid Hormones on AT1R MRNA Levels in HEK 293 Cells: Implications for Early-Onset Hypertension in Children Born of Preeclamptic Women
… flow. Thyroid hormone can increase production of angiotensinogen, which is a part of the renin-angiotensin system (RAS). RAS regulates blood pressure. Hypothesis: HEK 293 cells treated with T3 and T4 will have more angiotensin II type I receptors than those not treated with T3 and T4. Those HEK …
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Factors Regulating the Intrarenal Renin-Angiotensin System and Renal Damage During Aging
… gene expression of brain (dorsomedial medulla) angiotensinogen with a similar trend for renin, while the expression of ACE2 and neprilysin remain the same with a decrease in ACE expression compared to younger animals. There was no change in the gene expression of AT1a, AT1b, AT2 or Mas receptors …
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Modulators of Baroreflex Function in Conditions Associated with Hypertension
… assessed in older ASrAOGEN rats with low brain angiotensinogen. These studies show that maintenance of angiotensin-(1-7) and loss of angiotensin II tone within the solitary tract nucleus (NTS) may be an important mechanism contributing to preservation of baroreflex function during aging. …
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Pathogenesis of Dry Eye in Graft Versus Host Disease (GVHD): Role of Ocular Mucins and Conjunctival Fibrosis
… of renin-angiotensin system component (RAS), angiotensinogen and angiotensin converting enzyme, was also noted in the conjunctiva suggesting that ocular GVHD causes conjunctival fibrosis by myofibroblast formation and activation of conjunctival RAS.</p>
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A ROLE FOR ANGIOTENSIN-(1-7) TO ATTENUATE ADVANCED GLYCATION END PRODUCT -INDUCED MYOFIBROBLAST TRANSITION IN THE NRK-52E RENAL PROXIMAL TUBULE CELL LINE
… in NRK-52E cells. The RAS precursor protein angiotensinogen (AGT), and its processing enzyme renin were visualized by immunofluorescent (IMF) staining in the cell nuclei; we confirmed the protein expression in isolated nuclei by immunoblots. Renin activity (AGT to Ang I conversion) was …
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Acer, a homologue of the human angiotensin-1 converting enzyme, modulates the response of sleep, glycogen storage, lifespan, fecundity and stress resistance to diet in Drosophila melanogaster
… System (RAS) in humans. Renin cleaves angiotensinogen to angiotensin I and ACE regulates the vasoconstriction of blood vessels by converting angiotensin-1 to angiotensin-2 (a potent vasoconstrictor) and also by breaking down bradykinin (a potent vasodilator). Renin is regulated by a …
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Single Nucleotide Polymorphisms Linked to Essential Hypertension in Kasigau, Kenya
<p>Hypertension, or high blood pressure (BP), is an ever-growing epidemic in the developing world. Understanding the genetics behind essential hypertension (EH), or hypertension with no known cause, is especially important. In this study, three single nucleotide polymorphisms (SNPs) known to be …