Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Angiotensin-II type 2 receptor"”.
-
A Structural and Functional Analysis of the Human Angiotensin II Type-2 Receptor
… of the cytoplasmic loops and tail of the AT 2 receptor are used to determine what regions are important to G-protein activation. These studies will map the G-protein coupling regions of the human AT2 receptor and develop a wider understanding of AT2 receptor/G-protein interactions.
-
Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
… patients have been identified. Infusion of angiotensin II into mouse models causes aortic disease through inflammation and fibrosis. An angiotensin type I receptor (AT1R) blocker (ARB) or an angiotensin converting enzyme (ACE) inhibitor (ACEi) can reverse aortic pathology in some mouse …
-
CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… (HSD) on the expression of protein endocytic receptor megalin and its impact on proteinuria, particularly in obesity is not known. There are indications suggesting the involvement of glycogen synthase kinase (GSK)-3β-mediated megalin phosphorylation, and its subsequent endocytosis and …
-
Role of Angiotensin II Type 2 Receptors in Oxidative Stress and Inflammation
… to hypertension in obesity/diabetes. The renin angiotensin system (RAS) is the major hormonal system which affects sodium balance, oxidative stress and inflammation mainly via activation of Angiotensin II- AT1 receptors. We have recently shown that renal AT2 receptors are upreguated in obese …