Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Angiotensin-(1-7)"”.
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Angiotensin-(1-7) Reduces Prostate Cancer Growth and Metastasis by Altering the Tumor Microenvironment
… and in tissues by proteolytic cleavage of angiotensin I or II. The heptapeptide mediates biological responses by activating a unique G-protein-coupled angiotensin-(1-7) [AT(1-7)] receptor mas, thereby providing specific targeted actions when used as a therapeutic agent. In this study, …
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Molecular Mechanisms for the Angiotensin-(1-7)-Mediated Inhibition of Metastatic Triple Negative Breast Cancer
Approximately 40,000 women in the U.S. die from breast cancer annually. An estimated 15% of all breast cancers are triple negative, wherein tumors lack estrogen receptor and progesterone receptor expression and possess unamplified human epidermal growth factor receptor 2 (HER2) levels, contributing …
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The Role of Angiotensin-(1-7) in the Modulation of Angiotensin II-Dependent Cardiac Remodeling
… of both hemodynamic and humoral factors, such as angiotensin II (Ang II). Angiotensin-(1-7) [Ang-(1-7)] is an endogenous heptapeptide of the renin-angiotensin system with anti-proliferative properties which oppose the actions of Ang II. The purpose of this study was to determine whether Ang-(1-7) …
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ANGIOTENSIN-(1-7): A NOVEL SMALL MOLECULE FOR THE TARGETED TREATMENT OF TRIPLE NEGATIVE BREAST CANCER
ABSTRACT Soto-Pantoja, David Ricardo ANGIOTENSIN-(1-7): A NOVEL SMALL MOLECULE FOR THE TARGETED TREATMENT OF TRIPLE NEGATIVE BREAST CANCER Dissertation under the direction of E. Ann Tallant, Ph.D., Professor and Patricia E. Gallagher Ph.D., Associate Professor Triple negative breast cancer (TNBC), …
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REGULATION OF C-MET RECEPTOR TYROSINE KINASE SIGNALING BY ANGIOTENSIN-(1-7) IN TRIPLE NEGATIVE BREAST CANCER
Breast cancer remains a devastating disease, negatively impacting the lives of many women worldwide. In the United States, 40,450 women succumbed to breast cancer in 2015, with an estimated 247,000 new cases being diagnosed in 2016. Approximately 15% of all breast cancer cases will be classified as …
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Angiotensin-(1-7): A Peptide Hormone Inhibitor for the Treatment of Breast Cancer Targeting the Tumor Microenvironment
… in this dissertation was to determine whether angiotensin-(1-7) [Ang-(1-7)], an endogenous seven amino-acid peptide hormone of the renin-angiotensin system, inhibits the growth of HER2-amplified and ER-positive orthotopic breast tumors and to identify the molecular mechanisms for the …
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STUDIES ON ANGIOTENSIN-(1-7) AND MITOCHONDRIA: THE ROLE OF AN INTRACELLULAR RENIN-ANGIOTENSIN SYSTEM WITHIN THE KIDNEY
… classic circulating hormonal system - the renin-angiotensin System (RAS), and specifically, the ACE-Ang II-AT1 receptor axis. We have focused strategically on investigating novel intracellular pathways by which Ang-(1-7) is generated and degraded since this alternative pathway within the kidney …
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The role played by angiotensin (1-7) in the regulation of renal haemodynamics and excretory function in anesthetized rats
… to the degree of activation of the Renin Angiotensin Aldosterone System (RAAS). This raised the question as why the magnitude of this diuresis and natriuresis was compromised in rats receiving a high sodium diet (suppressed RAAS) and enhanced in low sodium fed rats (activated RAAS)? Could …
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NEUROINFLAMMATION AND SEX-DEPENDENT SIGNALING WITHIN THE DORSAL MEDULLA IN A MODEL OF FETAL PROGRAMMING: EFFECTS OF ANGIOTENSIN-(1-7) SUPPLEMENTATION
… of the brain, renal and circulating renin-angiotensin systems (RAS) that shift the RAS to the pro-hypertensive peptide, angiotensin (Ang) II with lower expression of the antihypertensive peptide, Ang-(1-7). In cerebral spinal fluid (CSF) and dorsomedial medullary tissue both Ang-(1-7) and …
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A ROLE FOR ANGIOTENSIN-(1-7) TO ATTENUATE ADVANCED GLYCATION END PRODUCT -INDUCED MYOFIBROBLAST TRANSITION IN THE NRK-52E RENAL PROXIMAL TUBULE CELL LINE
… evidence for a role of intracellular renin-angiotensin system (RAS) in cell signaling, function and cardiovascular pathologies. Diabetic nephropathy is a very common complication in which tubulointerstitial fibrosis may arise from epithelial to mesenchymal transition (EMT) of the proximal …
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RADIATION-INDUCED BRAIN INJURY: NOT JUST A MICROGLIA AND HIPPOCAMPUS STORY ANYMORE
… a role. However, cognitive studies with renin-angiotensin system (RAS) blockers which increase Ang-(1-7), indicate that microglia and the hippocampus may not be the complete story. Thus, we hypothesized that radiation-induced brain injury may be prevented by i] targeting neuroinflammation in …
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EFFECT OF ANGIOTENSIN PEPTIDES ON VASCULAR REMODELING
… direct cost estimated at $286 billion each year. Angiotensin II (Ang II), one of the biologically active peptides of the renin-angiotensin system, elicits many maladaptive effects on the cardiovascular system. Over the past two decades, numerous studies demonstrated that the other biologically …
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Investigating the role of the Renin Angiotensin System in cancer
… as possible anti-cancer agents. The renin-angiotensin system (RAS) regulates blood pressure and cardiovascular homeostasis through Angiotensin Converting Enzyme-1 (ACE-1) and its homolog ACE-2. RAS has also been implicated in the progression of various cancers due to the increased action of …
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Modulators of Baroreflex Function in Conditions Associated with Hypertension
… and during alterations of the brain renin-angiotensin system (RAS). Specifically, we determined the contribution of angiotensin peptides and leptin to baroreflex sensitivity in order to understand mechanisms contributing to baroreflex dysfunction in aged and obese individuals. The …
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Sex-Related Differences in Hypertension and Renal Injury: Role of the Renin-Angiotensin System
… in men than in premenopausal women. The renin-angiotensin system (RAS) contributes to the development and maintenance of hypertension. Angiotensin II (Ang II) and angiotensin-(1-7) are two peptides derived from the RAS that possess vasoconstrictive and vasodilatory actions, respectively. Ang II …
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Mas Receptor Agonism for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
… target of interest is by modulating the renin-angiotensin system (RAS), mediated by the activation of the mas receptor. The RAS consists of a family of G-Protein Coupled Receptors (GPCR) that serve a dual role. The pathological arm includes angiotensin converting enzyme (ACE), angiotensin-II, …
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Renale Effekte von Angiotensin I und seinen Metaboliten bei experimenteller Hypertonie
… als aktiv angesehenen Metaboliten des Renin – Angiotensin – Systems sowohl auf den renalen Gefäßwiderstand, als auch auf die stimulationsinduzierte Freisetzung des Neurotransmitters Noradrenalin am Modell der isoliert perfundierten Rattenniere in WKY-Ratten und SHR-SP zu untersuchen. Die …
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AEROBIC FITNESS AND THE RENIN ANGIOTENSIN SYSTEM IN ADOLESCENTS BORN PRETERM WITH VERY LOW BIRTH WEIGHT
… There is growing 2 evidence that the renin angiotensin system (RAS), another key component of BP control, may also be affected by both PT birth, as well as kidney development.10–13 In RAS, Angiotensin II (Ang II) acts as a vasoconstrictor, ultimately raising BP, whereas Angiotensin 1-7 (Ang …