Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Angiotensin converting enzyme 2 (ACE2)"”.
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Structural Basis of Bat and Raccoon Dog Angiotensin-Converting Enzyme 2 (ACE2) Receptor Recognition by Sarbecoviruses
… its receptor-binding domain (RBD) binds human angiotensin-converting enzyme 2 (ACE2) with high affinity despite limited apparent time for adaptation, and why some bat-derived RBDs paradoxically bind human ACE2 more strongly than bat ACE2. To address this question, we compared the RBDs of …
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Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
… pointing to loss of pharmacological function. ACE2 is a zinc-metalloproteinase type 1 transmembrane protein that cleaves angiotensin peptides to counter-regulate the renin-angiotensin-aldosterone system in the cardiovasculature and mediate hypotensive responses. The protein also acts as the …
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Accelerated simulations and computer-aided drug design of membrane proteins
… the mechanism of ligand recognition by human Angiotensin Converting Enzyme-2 (ACE2) receptor.
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Avaliação de genes auto inflamatórios em crianças com Síndrome Inflamatória Multissistêmica Pediátrica (SIM-P) associada à infecção pelo SARS-CoV-2
… crucial role in SARS-CoV-2 infection by cleaving Angiotensin-Converting Enzyme 2 (ACE2), the primary human receptor for SARS-CoV-2. Conclusion: Our data suggest that rare deleterious variants in genes previously implicated in auto inflammatory conditions, including ADAM17, IKBKG, PSTPIP1, SH3BP2, …
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Antibody production with synthetic peptides against human Coronavirus-NL63 ORF3 protein
… and the spike glycoprotein (S1 domain) use angiotensin‐converting enzyme 2 (ACE2) for infectious entry. Furthermore, CoV‐NL63 simplifies binding to ACE2 by attaching to heparan sulphate proteoglycans on the cell surface. ACE2 has a significant expression in airway differentiated epithelial …
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New Advances on the Biochemical Pathways in the Reninangiotensin System in Hypertension and their role in Cardiac Structure and Function
… are actually controlled. Because the renin‐angiotensin system (RAS) plays a major contributing role to the pathophysiology of hypertension and heart disease, the studies outlined in this dissertation traverse the complexities of the biochemical pathways within the cardiac renin‐angiotensin …
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Regulation of Substrate Metabolism and Renin-Angiotensin System with Dietary and Pharmacological Interventions: Implications for Obesity and Related Disorders
… (KD) on adipose tissue (AT) metabolism and renin-angiotensin system (RAS) function and potential implications for other tissues, including lung, heart and skeletal muscle. In the first study, it was demonstrated that despite increasing fat mass, a KD enhanced energy-dissipating mechanisms in white …
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Investigating the Unique Mechanism of Action of CADA Analogs for Down-Modulating CD4, Sortilin, and ACE2
… the down-modulation of several proteins (CD4, ACE2, sortilin) with the establishment of a pharmacokinetic profile of various biologically active CADA analogs. To achieve these goals, deuterium-labeled CADA analogs (CK147 and TL020) and several signal peptides (hCD4, mCD4, Q19A mCD4, Q16A Q19A …
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Impact of mutations in non-structural proteins on SARS-CoV-2 replication
… facilitates viral entry by binding to the angiotensin-converting enzyme 2 (ACE2) receptor. Meanwhile, non-structural proteins are involved in viral RNA synthesis, immune evasion, and the assembly of virions. Alterations in the genetic makeup of the SARS-CoV-2 genome, notably within the …
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Engineering of next-generation chimeric antigen receptors based on alternative binding domains
… extracellular domain on the human angiotensin-converting enzyme 2 (ACE2), which is the receptor for the SARS-CoV-2 virus Spike protein, a protein with such high variability that the design of scFv-based CARs, which might not be able to recognize different variants of this protein …
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Development of Novel PET Radiotracers for Neuroinflammation and COVID-19: Targeting FPR2, I2BS and ACE2
… 2 (FPR2), imidazoline-2 binding sites (I2BS) and angiotensin-converting enzyme 2 (ACE2) via PET. These molecular targets are important to understand the pathological processes in neuroinflammation and COVID-19. Over the course of project 1, automated radiosynthetic methods were developed to …
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SARS-CoV-2 Variants of Concern: Biological Implications of Immunogenicity and Comorbidity
… to express the primary receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2). As the infection of the K18 hACE2 mouse model with SARS-CoV-2 results in lethality, a dose needed to be chosen that the mouse survives in order to examine protection conferred by an initial infection. The mice …