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Showing 1 to 20 of 40 for “"Angiotensin converting enzyme (ACE)"”.
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Inhibitoren des Angiotensin Converting Enzyme (ACE) in hypoallergenen Säuglingsnahrungen
Als Schlüsselenzym im Renin-Angiotensin System übernimmt das Angiotensin Converting Enzyme (ACE) eine wichtige Rolle bei der Blutdruckregulierung. ACE spaltet das biologisch inaktive Angiotensin I zum vasokonstriktorisch wirksamen Angiotensin II, was zu einem Anstieg des Blutdruckes führt. Tier- …
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Identifikasi gen angiotensin converting enzyme (ACE) insersi/delesi (I/D) pada penderita hipertensi di Rumah Sakit dr. Saiful Anwar Malang
… menimbulkan kematian mendadak. Gen agiotensin converting enzyme (ACE) berhubungan erat dengan patogenesis hipertensi dan terletak pada kromosom 17 (17q23.3), terdiri dari 26 ekson dan 25 intron. Identifikasi gen ACE dilakukan dengan melihat kehadiran (insersi, I) atau ketidakhadiran (delesi, D) …
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The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380
Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the same enzymatic mechanism, ACE also …
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Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group
Angiotensin-converting enzyme (ACE) and P. falciparum A M1 (PfA-M1) are both zinc metalloproteases implicated in hypertension and malaria, respectively. Hypertension affects approximately 26 % of the world’s population while each year over 300 million cases of malaria occur worldwide resulting in …
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Prorenin, its maturation and the (pro)renin receptor
The renin-angiotensin system (RAS) is a key biochemical pathway controlling homeostasis and blood pressure. The initial step of the RAS is carried out by renin to produce angiotensin (Ang) I which is converted to Angll by the angiotensin-converting enzyme (ACE). Renin is synthesized as a pro-enzyme …
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Significance of active site residues in the n-domain selectivity of angiotensin-converting enzyme
Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that plays an important role in vascular function; with ACE inhibitors being clinically utilised in the treatment of cardiovascular disease and diabetic nephropathy. Somatic ACE consists of two homologous catalytically active domains …
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Rat angiotensin-converting enzyme : tissue specific expression during pharmacological inhibition
The renin-angiotensin system plays a central role in the maintenance of blood pressure. Angiotensin II, the main effector of this system, results from the action of angiotensin-converting enzyme (ACE) on angiotensin I. Angiotensin II, maintains vasomotor tone via its vasoconstrictor action, and …
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Association Between ACE Genotype and Skeletal Muscle Strength and Volume, and Their Response to Strength Training in Older Adults
… linked an insertion/deletion polymorphism in the angiotensin-converting enzyme (ACE) gene with variability in the response of muscle strength and mass to strength training, though conclusions have been inconsistent across investigations. The purpose of this study was to investigate the possible …
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The role of N-linked glycosylation on the structure and function of somatic angiotensin-converting enzyme
Angiotensin converting enzyme (ACE) is a key regulator of blood pressure and comprised of two homologous domains (N- and C-domain), both of which are glycosylated. N-linked glycosylation is important for the processing, expression and stability of ACE, but it interferes with protein …
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Studies on the angiotensin converting enzyme gene polymorphism and Ace inhibitors
Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II, an important step in the control of blood pressure. The gene encoding for ACE is subject to an insertion/deletion (I/D) polymorphism which is associated with different levels of the enzyme in serum. This polymorphism …
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Antimicrobial Inhibitory Activities of Phenolic Extracts from Four Selected Soybean Hulls in Culture and Chicken Skin Model Systems, and Preliminary ACE-Inhibitory Activity
… 0157:H7, and Campylobacter jejuni, and work as angiotensin-converting enzyme (ACE) inhibitory. In this study we: 1) Prepared phenolic extracts from four selected colored soybean varieties, 2) Determined the minimum inhibitory effects of the extracts on S. Typhimurium, E coli 0157:H7, and …
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The kidney in diabetes mellitus : urinary transfer in excretion, hypertension, the Renin-Angiotensin-Aldosterone system, and the role of angiotensin converting enzyme inhibitors in therapy
… Interventional studies with lisinopril, an angiotensin converting enzyme [ACE] inhibitor, in microalbuminuric and macroalbuminuric diabetic subjects show a reduction in TER independent of reduction in blood pressure. Data are presented suggesting a role for altered renal tubular function in …
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Clinical profiles and outcomes of patients receiving acute renal replacement therapy in the cardiac intensive care unit at a South African tertiary centre
… and some of these patients receive Renal Replacement Therapy (RRT). The clinical profiles and outcomes of CICU patients receiving RRT in resource constraint settings like South Africa is unknown. Objectives The objectives of this study were to determine the clinical profiles and outcomes of …
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The effects of centrally acting ACE inhibitors on the rate of cognitive and functional decline in dementia: a KDD approach
… is also growing evidence that centrally acting angiotensin converting enzyme (ACE) inhibitors, which cross the blood-brain barrier, are associated with a reduced rate of cognitive and functional decline in dementia, especially in Alzheimer’s disease (AD). The aim of this research is to …
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Myocardial fibrosis and pathological hypertrophy in the rat with aorta-constricted hypertension
… resulted from the activation of the renin-angiotensin system (RAS) due to renal ischemia. Microscopically, marked interstitial fibrosis with focal necrosis and diffuse perivascular fibrosis in the myocardium were observed. Myocardial fibrosis appears before myocyte necrosis and its severity …
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Lesioni degenerative e meccanismi di riparo della superficie oculare: lo pterigio e le deficienze delle cellule staminali del limbo (LSCD). Studio immunoistochimico e tecniche di coltura cellulare
Pterygium is a surface ocular lesion that is associated with chronic UV exposure, characterized by proliferation, inflammatory infiltrates, fibrosis, angiogenesis and extracellular matrix remodeling. The Angiotensin converting enzyme (ACE or ACE I) is the major component of the Renin-angiotensin …
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Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
… patients have been identified. Infusion of angiotensin II into mouse models causes aortic disease through inflammation and fibrosis. An angiotensin type I receptor (AT1R) blocker (ARB) or an angiotensin converting enzyme (ACE) inhibitor (ACEi) can reverse aortic pathology in some mouse …
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Prediction and Detection of Hypoglycaemia in Type 1 Diabetes
… the association between polymorphisms in Angiotensin Converting Enzyme ACE gene and severe hypoglycaemia in 77 participants in HypoCOMPaSS study. Interestingly, I found that the homozygous DD ACE gene polymorphism was associated with a significantly increased risk of severe hypoglycaemia. …
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A Molecular Basis for the C-Domain Selectivity of Angiotensin-Converting Enzyme
Angiotensin-Converting Enzyme (ACE) plays an essential role in blood pressure regulationand ACE inhibitors are widely used to treat cardiovascular disease. Two isoforms exist,somatic ACE (sACE) consisting of two homologous domains, N- and C-domain, and testisACE (tACE), corresponding to the …
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