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Showing 1 to 20 of 100 for “"Angiotensin converting enzyme"”.
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Inhibitoren des Angiotensin Converting Enzyme (ACE) in hypoallergenen Säuglingsnahrungen
Als Schlüsselenzym im Renin-Angiotensin System übernimmt das Angiotensin Converting Enzyme (ACE) eine wichtige Rolle bei der Blutdruckregulierung. ACE spaltet das biologisch inaktive Angiotensin I zum vasokonstriktorisch wirksamen Angiotensin II, was zu einem Anstieg des Blutdruckes führt. Tier- …
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Characterisation of the ectodomain shedding of angiotensin-converting enzyme
Bibliography: leaves 240-266.
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Protein-protein interactions of human somatic angiotensin-converting enzyme
… were engineered into the linker region of ACE [Angiotensin-converting enzyme] in an attempt to limit inter-domain movement, thereby producing a candidate for crystallisation and to determine the effect of these bridges on inter-domain movement.
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Rat angiotensin-converting enzyme : tissue specific expression during pharmacological inhibition
The renin-angiotensin system plays a central role in the maintenance of blood pressure. Angiotensin II, the main effector of this system, results from the action of angiotensin-converting enzyme (ACE) on angiotensin I. Angiotensin II, maintains vasomotor tone via its vasoconstrictor action, and …
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The search for the angiotensin converting enzyme sheddase recognition domain
Bibliography: leaves 171-191.
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Investigating domain-selective angiotensin converting enzyme inhibition and oxidative inactivation
Angiotensin converting enzyme (ACE) is a zinc metalloprotease comprised of two highly homologous, catalytically active domains (90% active site identity and 60% sequence similarity). The C-domain is responsible for blood pressure regulation via angiotensin I cleavage while the N-domain inactivates …
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Angiotensin-converting enzyme cleavage of the Alzheimer's beta-amyloid peptide
Angiotensin-1 converting enzyme (ACE) is a zinc metallopeptidase that consists of two homologous catalytic domains (N and C) with different substrate specificities. ACE is a central component of the intrinsic brain renin angiotensin-aldosterone system (BRAAS), well renowned as the regulator of …
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Structure-function and regulation studies of angiotensin-converting enzyme 2
Includes abstract. Includes bibliographical references (leaves 107-114).
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Studies on the angiotensin converting enzyme gene polymorphism and Ace inhibitors
Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II, an important step in the control of blood pressure. The gene encoding for ACE is subject to an insertion/deletion (I/D) polymorphism which is associated with different levels of the enzyme in serum. This polymorphism …
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Structure-function relationship of angiotensin-converting enzyme : glycosylation and domain-selectivity
Includes bibliographical references.
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Determination of the glycosylation requirements for active human testis angiotensin-converting enzyme
Bibliography: leaves 90-98.
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A Molecular Basis for the C-Domain Selectivity of Angiotensin-Converting Enzyme
Angiotensin-Converting Enzyme (ACE) plays an essential role in blood pressure regulationand ACE inhibitors are widely used to treat cardiovascular disease. Two isoforms exist,somatic ACE (sACE) consisting of two homologous domains, N- and C-domain, and testisACE (tACE), corresponding to the …
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A molecular basis for the C-domain selectivity of angiotensin-converting enzyme
Includes abstract. Includes bibliographical references (leaves 96-113).
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Mechanisms of chloride modulated activity in the C-domain of angiotensin-converting enzyme
The somatic isoform of angiotensin-converting enzyme (sACE), a key regulator of blood pressure and electrolyte fluid homeostasis, primarily cleaves the hypertension-associated angiotensin-I (AngI) and bradykinin peptides, as well as a number of other physiologically relevant peptides in vitro. sACE …
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The tetrapeptide Ac-SDKP and angiotensin converting enzyme in tuberculous pericarditis and fibrosis
… prolyl oligopeptidase (POP) and is cleaved by angiotensin-1 converting enzyme (ACE). Importantly, a role of ACE and Ac-SDKP in the regulation of inflammation and fibrosis in multiple tissues and organs has been increasingly described in the literature. This has prompted interest in both the …
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The effects of angiotensin-converting enzyme inhibitors as a pharmacological treatment for Dupuytren’s disease
… factors. There is some evidence that Angiotensin II (ANGT II) may be associated with this disorder and that blockers of ANGT II may help in treating this disease. This study was designed to investigate the presence of ANGT II receptors 1 (AT1) and 2 (AT2) in myofibroblasts derived from …
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Significance of active site residues in the n-domain selectivity of angiotensin-converting enzyme
Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that plays an important role in vascular function; with ACE inhibitors being clinically utilised in the treatment of cardiovascular disease and diabetic nephropathy. Somatic ACE consists of two homologous catalytically active domains …
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Structural determinants of the domain-selectivity of novel inhibitors of human testis angiotensin-converting enzyme
Includes abstract. Includes bibliographical references (leaves 79-93).
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The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380
Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the same enzymatic mechanism, ACE also …
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Structural Basis of Bat and Raccoon Dog Angiotensin-Converting Enzyme 2 (ACE2) Receptor Recognition by Sarbecoviruses
… its receptor-binding domain (RBD) binds human angiotensin-converting enzyme 2 (ACE2) with high affinity despite limited apparent time for adaptation, and why some bat-derived RBDs paradoxically bind human ACE2 more strongly than bat ACE2. To address this question, we compared the RBDs of …
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