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Showing 1 to 11 of 11 for “"Angiotensin II Type 1 Receptor"”.
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Engineering the angiotensin II type 1 receptor for structural studies
G protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that perform transmembrane signal transduction. Due to their pivotal role in a wide range of essential physiological functions GPCRs represent a high proportion of all drug targets. High resolution X-ray structures of …
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Angiotensin II-mediated Regulation of the Human Angiotensin II Type 1 Receptor Gene
The physiological responses of angiotensin II (Ang II) are mediated across the cell membrane through the angiotensin II type 1 receptor (AT1R), a heptahelical membrane protein coupled to trimeric G-proteins on the cytosolic side. AT1R on binding its ligand, Ang II, leads to downregulation of …
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Effect of Thyroid Hormones on AT1R MRNA Levels in HEK 293 Cells: Implications for Early-Onset Hypertension in Children Born of Preeclamptic Women
… the effect of thyroid hormones, T3 or T4, on angiotensin II type 1 receptor mRNA levels in human embryonic kidney cells (HEK). Maternal preeclampsia is a prediction of higher ambulatory blood pressure (ABP) in the exposed offspring. The mother's blood pressure affects the blood pressure of the …
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Effect of Blood Volume Manipulations and Warm Acclimation on Cortisol Levels in the Antarctic Teleost Trematomus bernacchii
Antarctic fish, such as the Trematomus bemacchii, maintain a serum osmolality of around 600 mOsm, nearly twice that of temperate fish. This high serum osmolality seawater surrounding Antarctica. Upon warm acclimation Antarctic fish lower their serum osmolality, increase their drinking rate, and …
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Triggering Nox2 / ROS Signaling During Disuse-Induced Skeletal Muscle Atrophy
… Evidence indicates that activation of angiotensin II type 1 receptor (AT1R) is an upstream event leading to Nox2 complex formation and activity. In the current study, we used an AT1R blocker (losartan) to test the hypothesis that AT1R activation is an upstream signaling event driving …
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Tumor necrosis factor induced oxidative stress in the central nervous system contributes to sympathoexcitation in heart failure
… following MI in conjunction with ROS and angiotensin II type-1 receptor blockers. These studies provide new evidence that TNF induces oxidative stress in the PVN through an AT1R mediated mechanism in CHF, and offers new insight into the sympathoexcitatory mechanisms in the brain possibly …
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Hepatic and Extra-hepatic Metabolism in NAFLD and the Role of Hepatocyte Oxygen Sensing
… and lipid metabolism. To investigate this, wild type mice and mice with a hepatocyte-specific deletion of *Epas1* were fed a high-fat, high-fructose, high-cholesterol diet (GAN diet) for 28 weeks and hepatic pathology and metabolism were assessed alongside measures of cardiac, renal and …
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Neue Aspekte der Nierenpathophysiologie durch Untersuchung von humanen Angiotensin II Typ I Rezeptor aktivierenden Antikörpern und SLC12A3 Mutationen
… wird eine übersteigerte Aktivierung des Renin-Angiotensin-Aldosteron-Systems verantwortlich gemacht. Die Penetranz der Erkrankung in betroffenen Familien sowie Mechanismen vaskulärer Komplikationen nach Nierentransplantation, insbesondere durch Angiotensin II Typ I-Rezeptor aktivierende …
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Preeclampsia, Autoimmunity and The At1 Receptor
… of PE remains unclear, an imbalance in the renin-angiotensin and immune systems are thought to be major contributors. Bridging these two concepts, it has recently been shown that women with PE harbor specific autoantibodies: the angiotensin II type 1 receptor activating autoantibody (AT1-AA). …
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Role of Angiotensin II Type 2 Receptors in Oxidative Stress and Inflammation
… to hypertension in obesity/diabetes. The renin angiotensin system (RAS) is the major hormonal system which affects sodium balance, oxidative stress and inflammation mainly via activation of Angiotensin II- AT1 receptors. We have recently shown that renal AT2 receptors are upreguated in obese …
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Telemetrisch kontrollierte Blutdrucktherapie bei Patienten mit unzureichend eingestelltem Hypertonus
Einleitung: Obwohl Bluthochdruck aufgrund seiner hohen Prävalenz und Mortalität die Volkskrankheit "Nummer 1" darstellt, sind nur etwa 30% der Hypertoniepatienten in Deutschland ausreichend behandelt. Es ist daher zur Risikoprophylaxe von Folgeerkrankungen und aufgrund der sozioökonomischen …