Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Angiotensin II Receptor"”.
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Angiotensin II receptor blockade and insulin sensitivity in overweight and obese adults with elevated blood pressure
… resistance in obesity hypertension is renin-angiotensin system (RAS) overactivation. The RAS exhibits vasocontricting and sodium-retaining properties, yet in vivo and in vitro animal experiments suggest impairment of whole-body insulin sensitivity with increased angiotensin II (Ang II) …
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Losartan, an angiotensin II receptor blocker, fails to attenuate pulmonary dysfunction in ovine burn and smoke model
Elevated levels of angiotensin II (AngII) in the lung have been shown in response to burn and smoke inhalation injury. AngII has been associated with increased nitric oxide levels, leading to nuclear oxidative damage in Type II lung epithelial cells. Losartan is an AngII, AT1A specific receptor …
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Combination Treatment of Angiotensin-II Receptor Blocker and Angiotensin-Converting-Enzyme Inhibitor in Non-Diabetic Renal Disease on Effect of Reducing Proteinuria
BACKGROUND: The fact that angiotensin-converting enzyme inhibitors(ACEI) and angiotensin receptor blockers(ARB) antagonize the renin-angiotensin system at different levels suggests that these agents, already confirmed by clinical benefit in retarding the progression of chronic renal disease, may …
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Role of Dopamine Receptor 3 in Cardiac Fibrosis
Dopamine receptors are known to exist primarily in the central nervous system and have been extensively studied there. However, other organ systems in the periphery, such as the kidney, have been shown to express these receptors as well. Studies on dopamine receptors in the cardiovascular system …
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RUOLO DELLA STIMOLAZIONE VAGALE SULLA PROLIFERAZIONE DEI FIBROBLASTI CARDIACI IN VIVO IN MODELLO ANIMALE DI FIBRILLAZIONE ATRIALE.
… 60 days, after 24 h 10 rats were treated with angiotensin II drugs for 60 days (AF + VNS + Ang II). The second group received vagal stimulation (VNS) and follow for 60 days, after after 24 h 10 rats were treated with angiotensin II drugs for 60 days (VNS + Ang II). The third group received …
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Development of Novel Therapies for Marfan Syndrome using a Human iPSC-disease model
… activity. Substantial efforts observed that angiotensin II receptor (AngIIR) blockade is able to rescue promiscuous TGF-β signalling and aortic complications in a MFS mouse model (Habashi et al. 2006). However, results in clinical trials have been disappointing (Lacro et al. 2014) and it is …
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The Morbidity & Mortality of Prevalent Heart Failure
… of beta-adrenergic blockade (β-blockers), angiotensin-converting-enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) to the most tolerable levels in order to reach target dosages, as recommended by the Heart Failure Society of America (HFSA). Patients were classified into …
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The Effect of Withdrawal of Angiotensin II Blockers on Serum Creatinine and Potassium in Patients with Chronic Kidney Disease
BACKGROUND: Renin-angiotensin system (RAS) blockers have been used to delay the progression of various renal diseases, but these medications cause hyperkalemia and the elevation of serum creatinine which impede the continuation of the medications. So far, there have been no data which observe the …
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Mechanisms underlying monosaccharide stimulated incretin hormone secretion from the intestine
Obesity and type II diabetes (T2D) are healthcare crises with continually rising prevalence worldwide. Drugs which mimic the gut hormone glucagon-like peptide-1 (GLP-1), e.g. Semaglutide, are currently the most effective obesity and T2D therapeutics, activating GLP-1 receptors in the pancreas and …
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Single Nucleotide Polymorphisms Linked to Essential Hypertension in Kasigau, Kenya
… in three genes that are part of the renin angiotensin system, the primary regulatory pathway in humans controlling BP. They include: AGT (rs699), AGTR1 (rs5186), and HSD11β2 (rs5479). Overall, by using a fluorescent-based RT-PCR technique, the genotype distribution of AGT (rs699) was 0.63 …
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Engineering the angiotensin II type 1 receptor for structural studies
G protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that perform transmembrane signal transduction. Due to their pivotal role in a wide range of essential physiological functions GPCRs represent a high proportion of all drug targets. High resolution X-ray structures of …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… of vasoconstrictor substances and increased receptor expression [17]. The early inflammatory response, which often is associated with the blood vessels, starts immediately or a few hours after the onset of the ischemia and contributes to the irreversible damage [18-21]. Currently, there are …