Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Angiogenin"”.
-
Biological Functions of ribonuclease 1 and angiogenin
… functions for two ptRNases, RNase 1 and angiogenin, through characterization of murine model systems. In Chapter 1, I introduce the ptRNase superfamily and highlight evidence of biological function for RNase 1 and angiogenin that has motivated and informed our study of these enzymes. …
-
Placental angiogenesis and immune-privilege in normal and pathological pregnancies
… CAMs. Studies on the pivotal angiogenic factors, angiogenin as well as PlGF, EGF and VEGF were conducted in normal and in pregnancies complicated by PE and IUGR. Angiogenin was identified for the first time to be produced in a gestation dependent manner with significantly increased levels of …
-
RNA modifications and processing in cell homeostasis and in response to oxidative stress
… their cleavage into small ncRNA fragments by angiogenin, I asked how angiogenin or tRNA-derived ncRNAs affect translation levels. In the presence of NSun2, angiogenin alone did not reduce global protein synthesis, yet tRNA fragmentation was required to modulate translation levels. Finally, to …
-
The Unfolded Protein Response Increases Production of Pro-Angiogenic Factors by Tumor Cell Lines
… growth factor 2 (FGF2), interleukin 8 (IL-8) and angiogenin. Using quantitative real-time PCR, we confirmed that a number of UPR inducing conditions (i.e., thapsigargin, tunicamycin, and no glucose) up-regulated VEGF, IL-8 and Angiogenin transcripts and extended these finding to a rat glioma line, …
-
Expression of angiogenic growth factors in laryngeal carcinoma
… proteins demonstrated increased levels of angiogenin in early stage tumours (p =0.034) compared with late stage of the tumour and increased IGF BP3 in tumours compared with the matched metastatic nodes (p = 0.016). No statistically significant results were observed for VEGF, FGF, TIMP1 or …
-
Biogenesis of Y RNA–derived small RNAs
… the enzyme which produces fragments from tRNAs, angiogenin, was also not responsible for YsRNA generation. Using mammalian cultured cells along with gene knockout and RNA interference (RNAi) technology, it was determined that RNase L contributed to YsRNA generation. Furthermore, the Y RNA binding …
-
Role of p53 and its isoforms in the expression of FGF-2 and tumoral neovascularization
… resulted in specific down-regulation of Angiogenin and hepatocyte growth factor, whereas the main angiogenic factors FGF-2 and VEGF-A were not significantly affected. Secondly we investigated the regulation of FGF-2 by p53 and its isoforms D133p53 in a human osteosarcoma cell line U2OS, …
-
Contribution of the Unfolded Protein Response to VEGF Expression
… that four of these factors, VEGFA, FGF2, angiogenin and IL8, were transcriptionally up-regulated in multiple cell lines by various ER stress inducers. Our studies on VEGFA regulation revealed that ATF4, a UPR-inducible transcription factor, bound to the mouse and human VEGFA promoters. …
-
CHCHD2 and the tumor microenvironment in glioblastoma
… the greatest secretion of CCL2, IGFBP-2, TIMP-4, angiogenin, and IGFBP-3. HMC3 conditioned media decreased expression of the system xc- antiporter and increased glutathione oxidation in mitochondria of U87 cells, while xCT expression and mitochondrial glutathione redox status in U87vIII cells …
-
Η ΒΙΟΣΥΝΘΕΣΗ ΤΩΝ ΒΑΣΙΚΩΝ ΜΕΜΒΡΑΝΩΝ ΩΣ ΒΙΟΧΗΜΙΚΟΣ ΔΕΙΚΤΗΣ ΤΗΣ ΑΓΓΕΙΟΓΕΝΕΣΗΣ
THE PRESENT THESIS CONCERNS THE DEVELOPMENT OF A NEW METHOD FOR ASSESSING ANGIOGENESIS. THE SYSTEM CHOSEN IS THE CHORIOALLANTOIC MEMBRANE (CAM) OF THE CHICK EMBRYO, AND THE METHOD IS BASED ON THE RATE OF BASEMENT MEMBRANE (BM) BIOSYNTHESIS DURING EMBRYOGENESIS. MORPHOLOGICAL EVALUATION OF …