Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Angiogenic activity"”.
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Promotion and control of angiogenic activity in poly(ethylene glycol) diacrylate hydrogels for tissue engineering applications
Promotion and control of angiogenic activity have been achieved by covalently linking an angiogenic-signaling protein or peptide to poly(ethylene glycol) diacrylate hydrogels, thereby yielding a system which can be used to develop vascularized, functional engineered tissues. The field of tissue …
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Synthesis of Novel Antimycobacterials and a Fluorescent Sensor for Simple Carbohydrates
… acids will improve the antibacterial and anti-angiogenic activity of these compounds. The second objective was the synthesis of a simple fluorescent receptor for simple carbohydrates. A receptor using anthracene as the fluorophore has been completed demonstrating an improved yield over previous …
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Examining Sex Differences of Adipose Endothelial Cells and the Effects of Foxo1 Deletion
… highly expressed in female ECs despite higher angiogenic activity. FoxO1 knockdown or inhibition in females led to a dysfunctional EC phenotype which was marked by inflammation, oxidative stress, impaired mitochondrial function, and DNA damage. These endothelial disturbances caused by FoxO1 …
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A quantitative analysis of the development and remodeling of blood vessels in tumors : contribution of endothelial progenitor cells to angiogenesis and effect of solid stress on blood vessel morphology
… approaches. A model of the balance between angiogenic stimulators and inhibitors is developed to assess the effects of biochemical factors produced by the primary tumor on angiogenesis both locally and remotely. The model quantitatively describes how primary tumors can suppress metastases …
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Polymorphisms in the Flt1 gene and their relation to expression of the secreted Flt1 variant
… endothelial growth factor (VEGF) is a potent angiogenic agent. VEGF activates its biologic responses through two cell-surface receptors, Flt1 and Flk1. In addition to the transmembrane form of Flt1, the Flt1 gene also encodes a secreted, truncated form of the receptor (sFlt1) translated from …
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Synthetic Efforts Toward Hypoestoxide, Platensimycin, And Guttiferone G
… anti - cancer, malarial, and inflammatory activity. In particular, the in vivo anti-angiogenic activity that inhibits vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) make it especially interesting. Along with this biological profile, the challenging …
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Biological Functions of ribonuclease 1 and angiogenin
… in mice. Angiogenin is a ptRNase with unique angiogenic activity and suggested biological function in cancer and amyotrophic lateral sclerosis, as well as in cellular growth and quiescence. My studies demonstrate a fundamental role for angiogenin. In Chapter 3, I find that this enzyme is …
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Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases
… (HIF)-mediated expression of pro-angiogenic genes under hypoxia is the fundamental cause of pathological neovascularization in ocular diseases and cancers. Thus, the inhibitors of the HIF pathway or key regulators such as histone demethylases (KDMs), that amplify HIF signaling, can …
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MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS
… and has led to the development of anti-angiogenic therapy in the treatment of cancer patients. Anti-angiogenic drugs targeting the vascular endothelial growth factor (VEGF) pathway may prolong progression-free survival and overall survival in some patients. However, the results are more …
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Exploring miR-142-3p in cervical cancer: Implications for treatment response
… that miR-142-3p itself does not drive pro-angiogenic activity and therefore does not pose a risk of enhancing tumor vascularization. Together, these findings highlight miR-142-3p as a promising molecular target for improving therapeutic sensitivity in cervical cancer without adversely …
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Design and Optimization of Angiogenic, Antibacterial Si-Zn-Hydroxyapatite for Use as Filler Particles in Polycaprolactone Nanocomposites
… can be limited by relatively low levels of bioactivity, inherent brittleness, slow in vivo resorption, and susceptibility to post-operative infection. This thesis establishes a mechanistically informed framework for engineering multifunctional bone-regenerative materials by controlling …
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Molecular imaging of spatio-temporal distribution of angiogenesis in hindlimb ischemia model and diabetic milieu
… spatio-temporal evaluation of the endogenous angiogenic response to ischemia was perfomed. After vascular occlusion, ischemic angiogenesis is an important reparative mechanism and can ameliorate the outcome of ischemic disease. Diabetic foot ulcers affect almost 15% of diabetic patients and …
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Effect of resection of localised pancreatic cancer on tissue-factor promoted pathways of thrombosis, cell invasion and angiogenesis
… identified PC as one of the most highly angiogenic and invasive malignancies, with the greatest prevalence and incidence of thrombo-embolism (TE). The incidence of TE in PC has been reported as high as 57%. Tissue factor (TF) bearing microparticles (MP) have recently been shown to promote …
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Multi-Platform Molecular Data Integration and Disease Outcome Analysis
… permeability, which in turn indicates the tumor angiogenic activity. Observing this activity over time can reflect the tumor drug responsiveness and efficacy of the treatment plan. However, due to the limited resolution of the imaging scanners, a partial-volume effect (PVE) problem occurs, which …