Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 348 for “"Angiogenic"”.
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Pro-Angiogenic Self-Assembling Peptides
Peptide amphiphiles (PAs), peptides that self-assemble into hydrogels with a nanofibrous network, are interesting biomaterials due to their biocompatibility and biodegradability. Self-assembling peptide-based materials include a wide range of peptide motifs that form one-dimensional nanostructures …
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Multiplexed angiogenic biomarker quantification on single cells
… tumor microenvironments. However, data on other angiogenic receptors, such as platelet derived growth factor receptors (PDGFRs), Tie receptors, are also necessary for the development of an accurate angiogenesis model. To gain insights on the involvement of these angiogenic receptors in …
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Platelets and Anti-Angiogenic Resistance In Ovarian Carcinoma
<p>Background: Resistance to targeted anti-angiogenic therapy is a growing clinical concern given the disappointing clinical impact of anti-angiogenic. Platelets represent a component of the tumor microenvironment that are implicated in metastasis and represent a significant reservoir of angiogenic …
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Expression of angiogenic growth factors in laryngeal carcinoma
… microenvironment, which may be involved in angiogenic processes occurring in laryngeal carcinoma, and associated metastatic nodes at different stages of disease, and to evaluate any potential therapeutic value.Both laryngeal tumour tissue and associated metastatic nodes were obtained from …
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Extracellular microenvironment for the regulation of endothelial angiogenic responses
… about the effects of extracellular signals on angiogenic responses and underlying intracellular signaling cascades in diabetic conditions. This lack of mechanistic understanding impedes technological advancement of new strategies for vascular tissue engineering therapies for DCM and diabetic …
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Targeting Metabolic Adaptations to Anti-Angiogenic Therapy In Ovarian Cancer
<h3><strong>ABSTRACT</strong><strong></strong></h3> <p><strong>Background: </strong>Ovarian cancer is the most lethal gynecologic malignancy. Despite modest clinical improvements with anti-VEGF antibody (AVA) therapy, adaptive resistance is nearly ubiquitous and additional therapeutic options are …
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Differential Angiogenic Capability and Hypoxia Responses in Glioma Stem Cells
… We measured the expression of a panel of angiogenic factors secreted by GSCs. In comparison with matched non-GSC populations, GSCs consistently secreted markedly elevated levels of vascular endothelial growth factor (VEGF), which were further induced by hypoxia. In an in vitro model of …
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Resident angiogenic mesenchymal stem cells from multiorgan donor thoracic aortas
… be fully established, it is believed that their angiogenic ability could be a useful property for allogenic use. These cells can be expanded rapidly, providing numbers which are adequate for therapeutic neovascularization; furthermore they can be cryostored in appropriate cell banking facilities …
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Predicting angiogenic receptor trafficking and signaling via computational systems biology
… endothelial growth factor (VEGF), a potent angiogenic growth factor, offers a promising therapeutic target. Despite this promise, VEGF targeted therapies are not clinically effective for many pathologies, such as breast cancer. Thus, a better understanding of the VEGF network for regulating …
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Cancer Associated Fibroblast Derived Angiogenic Factor Mfap5 In Ovarian Cancer Progression
… intratumor microvessel density, suggested a pro-angiogenic role of MFAP5. This study aims at delineating the functional roles and mechanisms by which stromal MFAP5 modulates ovarian tumor progression and angiogenesis and investigating the potential of targeting stromal MFAP5 as therapy for …
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Discovering angiogenic cell signaling landscapes: Quantitative mapping through experiment and computation
… such as the PDGFs. In cancer, for example, anti- angiogenic therapeutics primarily target the VEGF signaling family, but their success is limited by the development of drug resistance. These challenges in VEGF targeting, and recent discoveries of VEGF-A:PDGFR binding and signaling, presents a …
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Local pharmacokinetics and pharmacodynamics of angiogenic growth factors in myocardial tissue
Early enthusiasm over angiogenic therapy, a method to induce vascular regeneration to treat ischemic tissue with growth factors, has been tempered by a series of unsuccessful clinical trials with limited late efficacy and a wide range of mixed results. This thesis was designed to examine critically …
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ELUCIDATION OF THE UNIQUE TRANSLATION OF ANGIOGENIC SIGNALING BY AORTIC VALVE CELLS
… related signals. Therefore, the in vitro angiogenic capacity of valve endothelial cells was characterized and compared to vascular derived endothelial cells. Their vasculogenic networks were demonstrated to be quantitatively and morphologically different from the networks generated by a …
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Biomaterials for the extracellular control of mesenchymal stem cell pro-angiogenic potential
… of matrix elasticity and composition on MSC pro-angiogenic potential, showing elasticity can play a large role – dependent on matrix composition. In Chapter 3 we use micropatterning to reveal how changing cell shape (modulating cellular cytoskeleton, focal adhesions and contractility) can …
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Dynamics of vascular normalization during anti-angiogenic therapy : implications for combination therapy
… blood vessels for growth, and the goal of anti-angiogenic therapy is to destroy the tumor vasculature. Recent findings suggest that anti-angiogenic therapy enhances radiation and chemotherapy responses. These findings seem paradoxical, since anti-angiogenic therapy prunes tumor vasculature while …
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Evaluating the Expression of Angiogenic Mediators in a Mouse Model of Tumor Metastasis
… or a secreted form (sFlt-1) that can inhibit angiogenic signaling. Previous studies have shown that variation in mRNA expression of VEGF and its receptors KDR, sFlt-1 and Flt-1 occurs in pathological angiogenesis, i.e. metastatic tumorigenesis. We hypothesize that the ratio of sFlt-1:Flt-1 …
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A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
… connectivity and increased solution levels of angiogenic cytokines than lamellar systems. We extended this model into a 3D system by encapsulation of a 1 to 1 ratio of hCB-EPC and SMCs (30,000 cells/µl) within hydrogels of PEG-conjugated RGDS adhesive peptide (3.5 mM) and PEG-conjugated …
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Characterizing the anti-angiogenic resistance potential of cross-family PDGF:VEGFR2 interactions in glioblastoma
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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