Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"AngII"”.
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Structure, dynamics, and interactions of Angiotensin family of peptides with functional implications.
… that acts as a precursor to the octapeptide, AngII in the Renin Angiotensin Aldosterone system for blood pressure regulation. Smaller metabolites of AngII, including AngIII, AngIV and Ang₁₋₇, have recently been discovered to play an important role in blood pressure regulation. Experimental …
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Role of vascular smooth muscle Interleukin-11 in aortic aneurysm development
… (BSMKO) mice treated with Angiotensin II (AngII) for a period of 7 days. The BSMKO mice given AngII exhibited aneurysm formation, while the WT mice did not show this response. RNA sequencing of entire aortas from BSMKO mice and WT mice given this AngII treatment revealed that Interleukin-11 …
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Losartan, an angiotensin II receptor blocker, fails to attenuate pulmonary dysfunction in ovine burn and smoke model
Elevated levels of angiotensin II (AngII) in the lung have been shown in response to burn and smoke inhalation injury. AngII has been associated with increased nitric oxide levels, leading to nuclear oxidative damage in Type II lung epithelial cells. Losartan is an AngII, AT1A specific receptor …
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The role of Nox2 containing NADPH oxidase in hypertensive heart disease
… source of the Nox2 in a model of angiotensin II (AngII) induced left ventricular hypertrophy (LVH) and fibrosis.<br/>ROS production in resident cardiac fibroblasts was stimulated by AngII, aldosterone and TGFβ to investigate cardiac fibroblasts as a crucial cell source for Nox2. Only TGFβ elicited …
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ROLE OF ENDOTHELIN-1 IN THE REGULATION OF THE SWELLING-ACTIVATED Cl- CURRENT IN ATRIAL MYOCYTES
… Previously we showed that angiotensin II (AngII) signaling and reactive oxygen species (ROS) produced by NADPH oxidase (NOX) are involved in the activation of ICl, swell by both beta1-integrin stretch and osmotic swelling. Because endothelin-1 (ET-1) is a potential downstream mediator of …
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Studies into novel therapies for the treatment of inflammatory artery disease
… in human AAA tissue. In the angiotensin II (AngII)-infusion model of AAA and atherosclerosis in apolipoprotein-E gene-deficient (ApoE–/–) mice, administration of 2-thioxanthines (2-TX), a clinically-trialled MPO inhibitor, significantly inhibited AAA but not atherosclerosis. Paradoxically, …
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Vitamin D and cardiac autonomic tone: Cardiovascular implications in humans with and without chronic kidney disease
… In healthy humans undergoing an angiotensin II (AngII) vascular stress test prior to vitamin D supplementation, subjects with low 1,25(OH)2 vitamin D experienced withdrawal of cardioprotective vagal tone and an upwards shift in overall cardiosympathovagal activity [(∆HF from baseline = -6.98±3, …
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Exploring the role of Wnt signalling in heart failure with preserved ejection fraction.
… the optimum experimental conditions for AngII (1μM)-induced cardiomyocyte hypertrophy. Furthermore, subsequent experiments determined that AngII-induced cardiomyocyte hypertrophy is mediated, at least in part, via activation of canonical Wnt signalling; this thesis is the first to …
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Determining if the Developmental Origin of Cardiac Fibroblasts Determines the Fate of Activation in Adult-Onset Hypertension
… postnatal period, before challenging them with AngII/PE in adulthood to determine if they reactivate upon injury. Histological analysis of whole hearts confirmed treatment dependent ECM remodeling following injury. This thesis demonstrates that Postn-lineage derived fibroblasts are poised to …
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AEROBIC FITNESS AND THE RENIN ANGIOTENSIN SYSTEM IN ADOLESCENTS BORN PRETERM WITH VERY LOW BIRTH WEIGHT
… enzyme (ACE; the enzyme that converts ANGI to AngII), ultimately implicating RAS as having a role in developing HTN within this population.10,11,13 Preterm birth has also been associated with reduced cardiorespiratory fitness as well as participation in physical activity (PA).17,18 It is well …
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Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
<p>Thoracic aortic aneurysms and dissections (TAAD) are a major cause of morbidity and mortality in patients. Many different risk factors have been associated TAAD, but hypertension is the largest risk factor. Subsets of TAAD patients have identifiable syndromic genetic diseases, yet a number of …