Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Ang2"”.
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The Role of Angiopoietin-2 in Signaling Through the Endothelial Receptor Tyrosine Kinase Tie1
… in this thesis investigated the effects of Ang2 on Tie1 activation, signaling, and cellular responses within the context of both native and immortalized endothelial cells. Additionally, we investigated the role of Ang2 in the cellular reorganization and subsequent downregulation of Tie1. We …
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Role of The Ang-Tie2 Pathway In The Invasive Recurrence of Gbm Following Anti-Vegf Therapy
… we have shown that expression of angiopoietin 2 (Ang2), a Tie2 ligand, is dramatically increased in the periphery of the tumor after aflibercept treatment. Interestingly, our data provides evidence that Ang2 is chemoattractant to TEMs, both <em>in vitro</em> and <em>in vivo </em>suggesting a …
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Δυσλειτουργία του ενδοθηλίου σε ασθενείς που λαμβάνουν θεραπεία με Τ-λεμφοκύτταρα με χιμαιρικό αντιγονικό υποδοχέα
… από αυτή τη διάσταση. Η αγγειοποιητίνη 2 (ANG2) είναι το κυρίαρχο μόριο που έχει προκύψει ως κεντρικό στην παθοφυσιολογία των CAR- T τοξικοτήτων. Από τους πλέον εύκολα διαθέσιμους δείκτες υποκατάστασης ο δείκτης ενδοθηλιακής ενεργοποίησης και στρες (EASIX) ,ο τροποποιημένος m-EASIX αλλά και …
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Characterizing the Phosphorylation State of Tie2 using SH2 Domain Fusion Proteins
… to act as ligands for Tie2, of which Ang1 and Ang2 are best characterized. Activation of the receptor causes dimerization and autophosphorylation, whereby adaptor proteins recognizing the phosphorylated tyrosine activate downstream signaling via their Src homology 2 (SH2) domains. Currently …