Global ETD Search
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Showing 1 to 20 of 134 for “"Aneurysm"”.
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Imaging of abdominal aortic aneurysm disease activity and implications for endovascular aneurysm repair
BACKGROUND: Abdominal aortic aneurysm treatment pathways are initiated when an aortic size threshold of 55 mm is reached as this signifies a high annual risk of rupture due to presumed active aneurysm disease. Endovascular aneurysm repair (EVAR) is one treatment modality which reduces the …
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Outcomes of ruptured abdominal aortic aneurysm
Ruptured abdominal aortic aneurysm (RAAA) is a life-threatening event, and without operative treatment the patient will die. The overall mortality can be as high as 80-90%; thus repair of RAAA should be attempted whenever feasible. The quality of life (QoL) has become an increasingly important …
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Risk Factors in Abdominal Aortic Aneurysm
The mortality rate of ruptured abdominal aortic aneurysm (AAA) has been reported to be as high as 85%. Evidence suggests that ultrasound screening reduces overall and AAA-related mortality. The aim of this study was to identify and document risk factors for AAA from the largest Welsh cohort …
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Molecular genetics of abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a common disorder and a major cause of death. Pathological processes involved in AAA formation include inflammation, proteolysis, angiogenesis and apoptosis. It has also a strong familial predisposition with linkage studies identifying chromosomes 19q13 and 4q31 …
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Abdominal Aortic Aneurysm – Different Aspects on Screening
Abstract Abdominal aortic aneurysm (AAA) is a hideous life threatening disease that most often is asymptomatic until it ruptures. Ruptured abdominal aortic aneurysm (rAAA) is a painful and serious predicament with a mortality of 80-90%. Half of the patients die before arriving to hospital, leaving …
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Sensitivity of Hostile Hemodynamics to Intracranial Aneurysm Geometry
An intracranial aneurysm (IA) is an abnormal outpouching of an artery in the brain and is thought to be present in about 1 in 30 adults. Rupture of an IA is a devastating event leading to death or disability in most cases. To supplement clinical treatment decisions, researchers have turned to …
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Prediction of outcome after abdominal aortic aneurysm rupture
… for outcome prediction after abdominal aortic aneurysm (AAA) rupture and to design and validate a novel risk scoring instrument. It also aims to examine the utility of novel predictive variables. Finally, it examines the functional outcomes achieved by survivors of aneurysm rupture.
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Osteoprotegerin: a pathological role in human abdominal aortic aneurysm
Rupture of Abdominal Aortic Aneurysm (AAA) is the end-stage, catastrophic failure of the aneurysmal aortic wall and is associated with a mortality rate of up to 95 percent. Presently, surgery is the only treatment option available but carries with it a mortality rate of up to five percent and is …
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Genetic dissection of essential hypertension and familial intracranial aneurysm
The studies of hypertension, described herein, combined complementary strategies to examine the relevance of human chromosome 5q31.1-qter to blood pressure as a quantitative trait, and hypertension as a qualitative trait. This distal region of chromosome 5 was focused upon due to its implication by …
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Novel strategies to increase Sirtuin-1 activity in aortic aneurysm
… in preventing vascular diseases, such as aortic aneurysm (AA) and dissection. We demonstrated that SirT1 in vascular smooth muscle (VSM), the major component of large arteries, is indispensable in maintaining vascular wall homeostasis to prevent the development of aortic dissection after …
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Collagen structure within aneurysm tissue in bicuspid aortic valve patients
Aortic aneurysms pose a substantial clinical problem, especially in individuals with bicuspid aortic valve (BAV) disease, as aneurysm formation is 50% more common in these populations. Although the exact cause of aortic aneurysms in BAV patients is still unknown, a growing body of research points …
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Total Plasma Homocysteine, Vitamins, Abdominal Aortic Aneurysm and Peripheral Vascular Disease
… between homocysteine and abdominal aortic aneurysm (AAA), peripheral vascular disease (PVD), and the effect of vitamin B<sub>12</sub> and folic acid blood levels on plasma homocysteine concentration. This study was aimed to examine this possible …
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Multiphysics Computational Model of Fluid Flow and Mass Transport in Aneurysm
<p>The abdominal aortic aneurysm is progressive, asymptomatic, and can eventually lead to rupture which is a catastrophic event leading to massive internal bleeding and possibly death. AAA cases have been characterized by the development of an intraluminal thrombus (ILT). The ILT correlates with …
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Mechanical Effects of Surgical Adhesives on Ascending Thoracic Aortic Aneurysm Replacement
<p>Ascending thoracic aortic aneurysm (aTAA) is a potentially lethal disease which grows gradually over time and may lead to aortic dissection and rupture. Currently, aTAA surgical repair using Dacron graft is a well-established treatment. In addition, surgical adhesives are frequently used in the …
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Fluid Flow Characterization in Rapid Prototyped Common Iliac Artery Aneurysm Molds
… model and a full vessel model of an iliac artery aneurysm. A PDMS half-vessel construct was manufactured, and the movement of dye through the construct was tracked by a cellphone camera. Thresholds were applied to each video in HSB or YUV mode in ImageJ, and analyzed to determine the velocity of …
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Role of vascular smooth muscle Interleukin-11 in aortic aneurysm development
BACKGROUND: The formation of aortic aneurysms (AAs) presents a significant cardiovascular risk, with limited treatment options. Our laboratory examined wild-type (WT) and BCL11B knockout (BSMKO) mice treated with Angiotensin II (AngII) for a period of 7 days. The BSMKO mice given AngII exhibited …
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Predicting the risk of progression in patients with thoracic aortic aneurysm
… biomarkers in a cohort of 50 patients with aneurysms of the arch and descending thoracic aorta. I have described within this thesis various obstacles (logistical and biological) to identifying biomarkers of aneurysm progression. Despite these challenges, I have created a unique dataset …
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