Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Anesthetics"”.
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Local Anesthetics in Post-Operative Endodontic Pain
… for patients who received long-acting local anesthetics. Male patients who received bupivacaine reported less post-operative pain than females who received bupivacaine. The trends observed in this study suggest that long-acting local anesthetics are effective in the management of …
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Shedding Light On General Anesthesia: Uncovering The Molecular Mechanisms For Propofol And Volatile Anesthetics
General anesthetics have played a pivotal role in the history of medicine. Despite accounts of their use within the earliest of human records, our understanding of anesthetic mechanisms remains unclear. Understanding these molecular mechanisms would be a significant advance toward enhanced drug …
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Do Buffered Local Anesthetics Provide More Successful Anesthesia Over Non-Buffered Solutions in Patients Requiring Dental Therapy? – A Systematic Review & Meta-Analysis.
… The pH of commercially available local anesthetics (LAs) is purposefully low (pH 3–4). Decreasing the pH extends the shelf life of the solution and prevents its early oxidation. However, a low pH may produce a burning sensation on the injection site, a slower onset of anesthesia, and a …
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A Pharmacological Analysis of the Ionic Channels of Nerve
… the nodal membrane. Other drugs including local anesthetics, some general anesthetics, and veratrine alkaloids exerted moderately specific effects on the components of current. The anesthetics abolished sodium currents and the veratrine alkaloids enhanced sodium currents and prolonged their time …
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Unsupervised tracking and automated analysis of multi-population neural activity under anesthesia
Volatile anesthetics play an essential role in the practice of modern medicine due to their widespread use in general anesthesia. Research on anesthetics has mainly involved studies of molecular effects on ion channels and receptors, or on alterations of gross neural activity across large brain …
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The Importance of the Multicomponent Display in Sexual Selection of Black Morph Girardinus metallicus (Pisces: Poeciliidae)
… via chemical anesthesia; however, the anesthetics may alter the resulting measurements, for example by darkening the skin. <em>Girardinus metallicus</em>, a poeciliid fish endemic to Cuba, has a multicomponent courtship and aggressive display. Black morph males exhibit black ventral …
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Development and Applications of Opioids Alternatives for Pain Management
… on tetrodotoxin (TTX) and capsaicin as novel anesthetics. Acute post-surgical pain typically lasts 5-7 days, while long-term pain management can span up to 12 weeks. Opioids are commonly used but are linked to serious side effects, including addiction, nausea, cognitive impairment, and fatal …
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Investigations on the Use of Ion Mobility Spectrometry for Clinical Chemistry Applications
… of physiologically active substances, including anesthetics, illicit drugs, and their metabolites. The IMS characteristics of animal tissues and other compounds such as amino acids and proteins were determined. Quality assurance and control procedures were developed for specific quality data …
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Using molecular dynamics to probe protein conformational transition mechanisms at the membrane surface
… a ligand-gated ion channel (LGIC) in response to anesthetics, which antagonize channel function. There is significant debate over the proper anesthetic binding site in LGICs, with extracellular, transmembrane, and ion conduction pore mechanisms proposed. A variety of molecular dynamics techniques, …
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The Effects of Propofol, Sodium Pentobarbital, and Ketamine Hydrochloride on <i>In Vitro</i> Mouse Embryonic Development
… is used to screen potential toxic effects of anesthetics used in egg retrieval for <em>in vitro</em> fertilization (IVF), or those of pharmacologic agents which may come in contact with the egg or early embryo. Mouse preimplantation 2-cell embryos were exposed <em>in vitro</em> to incremental …
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Herbals and Dietary Supplemets: Evaluation of Perioperative Nursing Forms
… preoperatively. Possible interactions with anesthetics and inhibitory coagulation effects of these products are clinically relevant. The perioperative nurses’ assessment and documentation of the patient’s use of herbals and dietary supplements, along with communicating to operating room team …
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Novel Incorportation Of Biomedical Engineering Algorithms (bispectral Index Guided Or Anesthetic Concentration Guided) In Real-Time Decision Support To Prevent Intraoperative Awareness Using An Electronic Anesthesia Information Mananagement System
… algorithm (incorporating the use of intravenous anesthetics) or an EEG-guided algorithm will reduce the known incidence of AWR.</p> <p>Methods: First, a MAC-equivalent alerting algorithm that incorporates the use of intravenous anesthetics was developed and retrospectively applied to previously …
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Supraspinal actions of pentobarbital on transmission through the spinothalamic tract
… of the molecular mechanistic actions of general anesthetics very little is known about the in vivo neural circuits involved in creating the state of general anesthesia. To date the common consensus is that general anesthetics act ubiquitously within the CNS. Recently, (Devor and Zalkind, 2001) …
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