Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Anesthesiology and Intensive Care"”.
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Aspects of sepsis/SIRS - An experimental study on fluid therapy, vitamin C and plasma volume in increased permeability
… toxins, cytokines, pro-inflammatory hormones and free oxygen radicals. This will result in leakage of plasma fluid to the interstitum with subsequent intravascular hypovolemia and potentially harmful tissue oedema. Restoration of plasma volume with intravenous fluids is a cornerstone in the …
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Cardiac arrest and therapeutic hypothermia: Prognosis and outcome
… cardiac arrest (CA). TH requires sedation and muscular relaxation, obscuring the clinical neurological examination for estimation of prognosis, and clinical decision making. Continuous amplitude-integrated EEG (aEEG) has been used to predict outcome in neonates suffering from asphyxia. In …
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Host response in sepsis
… Increased vascular leakage, vasodilation and heart failure cause circulatory disturbances challenging the intensivist. Despite modern medication and high technology supportive care, mortality is high. Key strategies include to find and take care of causative agents at the infection site. …
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Viscoelastic haemostatic assays and fibrinogen concentration tests during haemodilution: The effects of fibrinogen and factor XIII
… The efficacy of concentrates of fibrinogen and factor XIII in hypothermia and haemodilution has not yet been completely investigated. Clauss methods have not previously been evaluated perioperatively. Methods: Coagulation was assessed with rotational thromboelastometry (ROTEM) or free …
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Gas exchange with a reflecting system for inhalational anaesthesia
… a system open in regard to oxygen, nitogen and nitrous oxide, but closed to inhalational anaesthetics, was developed. This was achieved by a reflecting filter for inhalational anaesthetics made of active carbon. The principle has been developed into the commersially available Anesthetic …
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On Brain Oedema
Traumatic brain injury and bacterial meningitis may at a glance appear as two different disease entities. The host reaction, however, to both trauma and infection involves a strong inflammatory response, with the classical symptomology of rubor, tumor, calor, dolor et functio laesa. Tumor, …
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Influence of tidal volume on pulmonary gas exchange during general anaesthesia
Background and objective: General anaesthesia impairs respiratory function. The present studies were performed to compare arterial concentration of sevoflurane, oxygen and carbon dioxide in normal and overweight patients ventilated with increased tidal volume (VT), or normal tidal volume with and …
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Cardiac arrest – prognostic biomarkers and aspects of shock
… cardiac arrest but the outcome is still poor and 50-70% of patients do not survive despite successful return of spontaneous circulation (ROSC). The cause of death is multifactorial. The majority of patients die from brain injury, but up to 35% die as a result of circulatory failure. Purpose: …
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Non-invasive optical monitoring of free and bound oxygen in humans
… - both in its free form, as gas in the lungs, and in its bound form, as oxygenated hemoglobin - have been explored in this thesis. Perfusion and oxygenation of vital organs (e.g., heart, brain and kidneys) may be severely compromised in critical illness or major trauma, which is why blood is …
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Acute Confusional State in Elderly Patients with Hip Fracture. Identification of risk factors and intervention using a prehospital and perioperative management program
… to increase knowledge about underlying causes and perioperative risk factors of Acute Confusional State (ACS) in elderly patients with hip fracture and to investigate the effect of a multi-factorial intervention program in order to decrease the number of patients who develop ACS. The aim in …
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Induced hypothermia after cardiac arrest
… as an intervention to reduce mortality and neurological impairment after cardiac arrest. After the publication of two trials indicating benefit of induced hypothermia, we developed a registry to assess outcome, possible adverse events and conduct of induced hypothermia when this …
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Electroencephalography for neurological prognostication after cardiac arrest
… both simplified continuous EEG monitoring (cEEG) and routine EEG. Background: Comatose survivors are admitted to an intensive care unit (ICU) to support vital functions. Postresuscitation care includes target temperature management (TTM) for 24 hours. The degree of brain injury after CA varies …
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Actions of Antimicrobial Peptides and Bacterial Components in Inflammation
… ancient parts of the innate immune system and their primary role is to protect us from infections. The human cathelicidin-derived antimicrobial peptide, LL-37, not only possesses broad spectrum antimicrobial activities but is also able to bind and neutralize bacterial lipopolysaccharide …
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Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model.
… infarction, increased morbidity, mortality, and health care costs. In the first study, myocardial metabolism was investigated before, during, and after 30 min of regional coronary artery occlusion, utilizing the microdialysis technique, concomitantly with the monitoring of global circulation …
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Aspects of bleeding complications and hemostasis at central line insertion and mild induced hypothermia
… frequent in patients with bone marrow failure and severe thrombocytopenia. Although supportive evidence is scarce, prophylactic platelet transfusion is sometimes performed in these patients before catheter insertion. Furthermore, the ideal threshold platelet count and timing of transfusion …
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ASPECTS OF FLUID THERAPY: An experimental study of the effects of systemic inflammation, microvascular permeability, blood pressure and plasma volume
… Fluid therapy aims at correcting hypovolaemia, and is an important part of the haemodynamic management of perioperative and critically ill patients. The efficacy of plasma volume substitution largely depends on the pharmacological properties of the colloid solutions used. However, according to …
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The Microcirculation in Trauma and Sepsis
… plays a vital part for fluid-, gas- and solute-exchange, and changes in permeability during trauma or sepsis, that are in part necessary for the natural healing process, may also cause hypovolemia and edema formation, leading to disturbances in microvascular exchange. This thesis …
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Aspects of retransfusion of shed blood in cardiac surgery
… bypass (CPB) has a long tradition and often regarded as mandatory. Recently, studies have described potentially negative effects of cardiotomy suction with activation of the complement system, enhanced inflammatory response, hemolysis and coagulopathy. Emboli of various matters has …
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In-hospital patient safety - prevention of deterioration and unexpected death by systematic and interprofessional use of early warning scoring
… nursing practice of bedside monitoring and management has recently been addressed as impending to in-hospital patient safety. Vital parameters have for two decades been known to deviate in individual patients hours ahead of serious adverse events, but this knowledge has not yet been …
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Using Probiotics in Intensive Care with Special Reference to Lactobacillus plantarum 299 and 299v
… but is easily disturbed by severe illness and the use of antibiotics. The intestinal barrier that separates the luminal contents, with a very high density of microorganisms, from an almost sterile milieu in the gut wall, is disrupted in critically illness. Probiotic bacteria have the …