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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 322 for “"Androgen"”.
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Understanding the mechanism of androgen biosynthesis
… that constitutes the first committed step of androgen formation. Though over 40 years have passed since discovery of this enzyme, key questions regarding the nature of the reactive intermediate responsible for androgen formation have heretofore remained unanswered. Specifically, while the …
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Tmprss2-Erg Regulation Of Androgen Biosynthetic Enzyme Expression, Dht Synthesis, And Androgen Receptor Activation In Prostate Cancer
<p>Intratumoral androgen synthesis in prostate cancer (PCa) contributes to the development of castration-resistant prostate cancer (CRPC). Several enzymes responsible for androgen biosynthesis have been shown to be overexpressed in CRPC, thus, contributing to CRPC in a castrated environment. …
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Androgen Receptor and Prostate Cancer Cell Heterogeneity
<p>Androgen receptor (AR) plays an important role in prostate cancer (PCa) development and has been the main therapeutic target in advanced PCa. AR expression is heterogeneous in both primary PCa and castration resistant prostate cancer (CRPC). However, the functional significance of AR …
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Associations Between Testosterone, Androgen Receptor Polymorphism, And Mood
… affect in men. Genetic variability in the androgen receptor (polyglutamine [CAG] repeat length) may be important for this relationship. However, the relationship between testosterone, androgen receptor CAG repeat length, and depressive affect remains inconclusive. The current thesis …
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G Protein and Androgen Signaling in Ovarian Function
Oocytes are held in meiotic arrest in prophase I until ovulation when gonadotropins trigger a subpopulation of oocytes to resume meiosis in a process termed "maturation." Meiotic arrest is maintained through a mechanism whereby constitutive cAMP production exceeds phosphodiesterase-mediated …
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Early Androgen Exposure, Gender, and Disorder-Relevant Traits
… of animal experiments have demonstrated that androgenic hormones, such as testosterone, during the prenatal and early postnatal periods, masculinise and defeminise various neural and behavioural characteristics that differ by sex. Can these findings from animal experiments be generalised to …
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Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
… and becomes resistant to the treatment options. Androgen receptor (AR) that is expressed in over 90\% of ER-positive breast cancer and in 20\% of TNBC is a pharmacologically targetable tumor suppressor in ER-positive breast cancer and a targetable oncogene in TNBC (luminal AR TNBC (LAR TNBC)). …
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Novel Techniques to Target Androgen Signalling in Prostate Cancer
… Current treatment options focus on targeting androgens, the male sex hormones. Reducing the levels or activity of androgens can shrink tumours significantly, however resistance is inevitable. Multiple mechanisms of resistance have been described, but often the tumours appear to remain …
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Androgen and Estrogen Interactions in the Immature Rat Uterus
Made available in DSpace on 2014-12-14T13:39:44Z (GMT). No. of bitstreams: 1 7821240.pdf: 5496119 bytes, checksum: 59b3df4d982332ed6cac73c7c9730d89 (MD5) Previous issue date: 1978
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The effect of androgen excess on cognitive functioning in women.
The effect of androgen excess on cognitive functioning in women.
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The Role of a Membrane Androgen Receptron in the Brain
Gatson, Joshua Wayne, The Role of a Membrane Androgen Receptor in the Brain. Doctor of Philosophy (Biomedical Sciences), February 2007, pp187, 34 illustrations. In the brain, depending on the insult type, androgens have been shown to protect from or exacerbate the levels of cell death. This …
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Genetic, environmental and life-style effects on androgen receptor function
Androgens regulate male reproductive function and their effects are mediated through the androgen receptor (AR). The AR gene contains a polymorphic CAG repeat, encoding a stretch of glutamines, affecting the transcriptional activity of the AR. Prostate specific antigen (PSA) is a downstream target …
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Synthesis and androgen receptor binding of novel derivatives of dihydrotestosterone
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Characterisation of Androgen Receptor Signalling and Metabolism in Prostate Cancer
… disease which affects men worldwide. The Androgen Receptor (AR) is responsible for driving disease progression, therefore therapies often target this signalling axis. Eventually, these treatments fail and the cancer progresses to an aggressive, incurable stage known as castrate-resistant …
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Second-site inhibitors of the estrogen and androgen hormone receptors
The estrogen and androgen receptors are members of the nuclear hormone receptor protein superfamily and play an important role in the development of primary and secondary female and male sexual characteristics. Although necessary for proper development, in certain contexts activation of these …
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Neuromuscular Junctions in Androgen Sensitive Muscles: A Model for Synaptic Plasticity
<p>Androgen-sensitive muscles are specialized muscles in which both muscle and motoneurons are highly sensitive to androgens. Previous studies have shown that alterations in the levels of circulating androgens affect the activities of cholinergic enzymes in two androgen-sensitive muscles; the …
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Investigating persistent organic pollutants as endocrine disruptors of androgen receptor signalling
… perfluoroalkyl acids (PFAAs) for disrupting androgen receptor (AR) signalling. <br/><br/>The Total POP mixture using in this project consisted of a combination of 29 chemicals modelled on the exposure profile of a Scandinavian population and 6 sub-mixtures: brominated (Br) chlorinated (Cl), …
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The Role of Androgen Receptor Signalling in Endocrine Resistant Breast Cancer
… represents a major clinical issue. The Androgen Receptor (AR) is a transcription factor that is more highly expressed than ERα in BCa, and mediates the functions of androgens. In early forms of ERα-positive disease, AR is a positive indicator of prognostic outcome and suppresses ERα …
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Insight Into the Metabolism of Lycopene: Focus on Androgen -Dependent Tissues
This research has shown that lyc metabolites accumulate in the prostate, seminal vesicles and adrenal gland compared to the other analyzed tissues. Moreover, modulated carotenoid cleavage enzyme(s) expression in the adrenal, prostate and kidney suggested that the accumulated lyc metabolites in …
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Proteolysis targeting chimeras for the directed ubiquitination of the androgen receptor
… a cellular environment. This work focuses on the androgen receptor (AR) protein, a key nuclear receptor for healthy prostate development. Hence, AR inhibition and degradation are well-established strategies for treatment of prostate cancer. First, in this work stapled peptide PROTACs recruiting E3 …
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