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Showing 1 to 20 of 68 for “"Anatomical Pathology"”.
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Atypical reactive lymphoid hyperplasia : a 5 year study with analysis of 10 cases for latent Epstein-Barr virus infection by in situ hybridization and immunohistochemistry
… hyperplasia (ARLH) received in the Department of Anatomical Pathology, UCT and GSH, over a 5 year period, in order to determine the number of cases of ARLH, and the frequency of the various subtypes of reactive lymphoid. hyperplasia, so as to provide base-line information for further studies. 2. …
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A study to investigate the role of P27 and Cyclin E immunoexpression as a prognostic factor in early breast carcinoma
… over a five year period to the Division of Anatomical Pathology, Groote Schuur hospital; Whittaker and Associates; and PathCare. All tumours included in this study were less than 5cm in diameter (pT1 and pT2 stage) and all the patients had wide local excisions peformed. Follow up information …
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Cytohistologic correlation of suspected Cervicofacial Head & Neck Extra-Pulmonary Tuberculosis in children: A retrospective case series
… (2012-2017). Following identification of histopathology accession numbers, histopathology reports and slides were retrieved from the archive of the Division of Anatomical Pathology/ National Health Laboratory Service, Red Cross Children's Hospital, Cape Town for evaluation. In addition, results …
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Differentiating follicular thyroid carcinoma from the follicular variant of papillary thyroid carcinoma
Introduction: Differentiating follicular adenoma (FA), follicular thyroid carcinoma (FTC) and follicular variant of papillary thyroid carcinoma (FVPTC) remain a diagnostic challenge in some cases. This is as a result of the assessment of nuclear features being highly subjective, and the threshold …
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International Academy of Cytology Yokohama System for reporting Breast Fine Needle Aspiration Biopsy (FNAB) cytology: A Retrospective Study in a Single South African Tertiary Institution
… institution by comparing it to the matched histopathology over a 12-month period. Methodology: A retrospective longitudinal descriptive study was done. A computerized search on TrakCare NHLS for the year 2019, identified 884 patients who had breast cytology and corresponding histology specimens. …
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Human Papillomavirus DNA extraction and genotype analysis by multiplex real time polymerase chain reaction from formalin fixed paraffin wax-embedded cervical carcinoma specimens
Introduction: Cervical squamous cell carcinoma is most commonly caused by persistent infection by high risk human papillomavirus (hrHPV) genotypes. The exact type of hrHPV varies geographically and is the basis for HPV–based vaccination for cervical squamous cell carcinoma prevention. Little is …
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Juvenile pilocytic astrocytomas: A search for prognostic markers
Introduction: Juvenile pilocytic astrocytomas are one of the most frequent central nervous system tumours occurring in children. While they are classified as WHO Grade I tumours, their natural progression is difficult to predict with some patients suffering significant morbidity and mortality …
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Identifying Children with Constitutional Mismatch Repair Deficiency (CMMR-D) Syndrome in the Expanding Lynch Syndrome population in Cape Town
INTRODUCTION: Constitutional Mismatch Repair Deficiency (CMMR-D) syndrome is a rare tumour predisposition and polyposis syndrome that presents in childhood. It is caused by mutations in mismatch repair (MMR) genes that result in a tumour spectrum including colorectal cancers, high-grade gliomas, …
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The role of tissue inflammation in Kenyan women with breast cancer
Background The immune landscape of breast cancer (BC) molecular subtypes from Sub Saharan Africa is understudied and findings are mainly extrapolated from studies in Caucasians. The objective of this study was to describe the cellular and signalling milieu of BC tumour microenvironment and its …
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The role of stem cells and WNT signalling pathway in renal cell carcinoma
… cell carcinomas diagnosed in the Division of Anatomical Pathology, National Health Laboratory Service, Groote Schuur Hospital over a 10-year period. To identify cancer stem cells in various histopathological subtypes of renal cell carcinoma using immunohistochemical markers (CD133 and CD105). …
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Neuroendocrine neoplasms of the digestive tract: retrospective classification according to the 2019 WHO grading system, and evaluation of the immunohistochemical marker INSM1
Neuroendocrine Neoplasms (NENs) of the Gastrointestinal Tract (GIT) are a heterogeneous group of tumours with varied biologic potential and clinical outcomes. They are classified as well differentiated neuroendocrine tumours (WD NET) or poorly differentiated neuroendocrine carcinomas (PD NECs) …
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Oesophageal squamous cell carcinogenesis : a study of cell cycle regulatory proteins by immunohistochemistry
… done on paraffin embedded tissues. The histopathology, grading and staging of all resected squamous cell carcinomas over a twenty one year period from 1982 to 2002, were reviewed. Sixty eight patients were identified; all had an oesophagectomy for OSCC at Groote Schuur Hospital, a tertiary …
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Expression levels of miRNA-127 in a cohort of HIV-positive and HIV-negative Diffuse Large B-Cell Lymphoma.
… were collected from the archive of Division of Anatomical Pathology, University of Cape Town/NHLS Groote Schuur. The H&E slides were assessed before RNA was extracted from FFPE tissue and converted to cDNA. Real time quantitative RT-qPCR was used to assess the expression of the microRNA. Normal …
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Interaction between DC-SIGN and DC-SIGNR with HHV-8 (LANA-1) and HIV-p24 in Castleman disease
… Fifty cases of CD diagnosed at the Division of Anatomical Pathology, National Health Laboratory Service, Groote Schuur hospital over a ten and half year period were included in the study. Double immunohistochemistry was used to characterise HHV-8 infected cells using LANA-1 antibody, in …
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The relationship between BRAF genetic alterations and the risk of tumour recurrence in Pilocytic Astrocytomas in children diagnosed at Red Cross Children's Hospital over a 33-year period
… (Disa and NHLS TrakCare) of the Division of Anatomical Pathology for all cases diagnosed with PAs. Data collection included: age at diagnosis, tumour site, management and recurrence. Laboratory methods: Archived stained slides of all the cases were reviewed, the diagnosis was confirmed on …
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An immunohistochemical study of beta-catenin in HNPCC colon tumours
Beta-catenin is normally complexed with adenomatous polyposis coli (APC) protein and E-cadherin adhesion molecule, and localized on the cell membrane. If APC/beta-catenin is disrupted, beta-catenin transfers into the nucleus, where it functions as a transcriptional activator, causing unregulated …
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Facial fatness as a complicating factor in facial reconstruction
… in facial tissue thicknesses comes from anatomical differences between populations, we do not know how much of normal variation is caused by including the full range of individual obesity or slimness. Current population standard soft tissue thickness data used in facial reconstructions …
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Biomarker identification in HIV and non-HIV related lymphomas
… lead to a better understanding of the disease pathology and better therapeutic design. Initially differences in the clinicopathological features between HIV negative and HIV positive DLBCL patients were determined by conducting a retrospective study of patients treated at GSH. Subsequent to …
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Crohn's Disease : diagnostic and prognostic indicators with special reference to granulomas
The fact therefore remains that, at the present time, Crohn's disease is still an enigma. The aetiology and pathogenesis are obscure, the clinical findings and progression of the disease are unpredictable and the histological findings are often nonspecific. With this in mind, this dissertation …
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A semiquantitative and qualitative histopathologic assessment of the effect of type II intrauterine growth retardation on the structure of the carotid bodies in fetuses and neonates
The major physiological function of the carotid body is to respond to a low partial pressure of oxygen in the systemic arterial blood. The structure and functions of the adult carotid body have been extensively investigated over the past fifteen years. However, the carotid body in children has been …
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