Global ETD Search
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Showing 1 to 14 of 14 for “"Anaplastic lymphoma kinase"”.
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FUNCTIONAL ANALYSIS OF ANAPLASTIC LYMPHOMA KINASE DURING EMBRYONIC NEUROGENESIS IN ZEBRAFISH
The orphan receptor tyrosine kinase gene Anaplastic Lymphoma Kinase (ALK) was initially discovered as an oncogene. ALK kinase over-activation has been associated with human cancers, most importantly neuroblastoma. However, little is known about ALK¿s endogenous function in development. I identified …
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Investigating the genome of Anaplastic Lymphoma Kinase-positive Anaplastic Large Cell Lymphoma
Anaplastic Large Cell Lymphoma (ALCL) is a T cell Non-Hodgkin Lymphoma, mainly presenting in paediatric and young adult patients. The majority of cases express a chimeric fusion protein resulting in hyperactivation of Anaplastic Lymphoma Kinase (ALK) as the consequence of a chromosomal …
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Multilevel Deregulation of Survival Mechanisms In Npm-Alk+ T-Cell Lymphoma
<p>The anaplastic lymphoma kinase (ALK) is a single chain transmembrane receptor tyrosine kinase that belongs to the insulin receptor superfamily. Other members of this superfamily include the insulin receptor (IR), type I insulin-like growth factor receptor (IGF-IR), and the leukocyte tyrosine …
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APPLICATION OF STRUCTURAL, MOLECULAR, AND PROTOEMIC STUDIES TO INVESTIGATE ON-TARGET AND OFF-TARGET MECHANISMS OF LORLATINIB RESISTANCE IN ALK DRIVEN NEUROBLASTOMA
… has improved patient survival and discovery of anaplastic lymphoma kinase (ALK) receptor activating mutations and amplification has provided hope to further increase of patient survival. Despite this success and that of precision medicine at large, patients treated with ALK inhibitor lorlatinib …
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Searching for the missing T Cell Receptor (TCR) in Anaplastic Large Cell Lymphoma (ALCL): Surplus to requirements or a protagonist in lymphomagenesis?
Anaplastic Large Cell Lymphoma (ALCL) is a peripheral T cell lymphoma divided into three distinct entities: ALCL, Anaplastic Lymphoma Kinase (ALK)+, ALCL ALK- and cutaneous ALCL. In the majority of ALCL, ALK+, ALK is expressed as the result of a chromosomal translocation generating Nucleophosmin …
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Anti-VEGF Therapy Modulates Immune Cell Infiltration and Function in Multiple Breast Cancer Models
… expressed, PTN stimulates the phosphorylation of anaplastic lymphoma kinase on tumor associated macrophages. These macrophages promote anti-inflammation, angiogenesis, immune tolerance, and metastasis. Importantly, these phenomena can be inhibited using the receptor tyrosine kinase inhibitor …
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Genetic Analysis of Bacterial Food Perception and its Influence on Foraging Behavior in C. elegans
… gain-of-function allele of scd-2, the C. elegans Anaplastic Lymphoma Kinase (ALK) gene ortholog, scd-2(syb2455),which I designed based on an oncogenic mutation in ALK. While animals with loss-of-function mutations in scd-2 are dauer-formation defective, scd-2(syb2455) animals enter dauer …
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ALK in the pathogenesis of cancer
Anaplastic Lymphoma Kinase (ALK) has been implicated in the pathogenesis of many types of cancer including Anaplastic Large Cell Lymphoma (ALCL) and neuroblastoma (NB). ALK is an ideal drug target as its endogenous expression is limited to neuronal cells during neonatal development, although …
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The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia
… ones which are associated with the activation of anaplastic lymphoma kinase (ALK), the plasma kallikrein-kinin system (KKS), the AKT-1 pathway, the MAPK pathways, the adenylate kinase system and involvement in the CD40-dependant activation of B-CLL cells. One of the protein targets found …
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Molecular mechanisms of floor plate formation and neural patterning in zebrafish
… of both Mdk proteins and the candidate receptor Anaplastic lymphoma kinase (Alk) have been compared. Knock-down of mdka and mdkb resulted in the same reduction of iridophores as in mutants deficient for Alk. This indicates that Alk could be a putative receptor of Mdks during zebrafish …
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Functional identification of molecular oncotargets associated with the resistance to ALK inhibition in neuroblastoma via genome-wide CRISPR-Cas9 screens
… neuroblastoma (hNB) patients have identified Anaplastic Lymphoma Kinase (ALK) as the only directly ‘druggable’ target with a significant mutation rate (9%). ALK is a receptor tyrosine kinase whose dysregulation has been implicated as the driver lesion in a variety of cancer types, including …
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Novel treatment strategy for ALK-positive Anaplastic Large Cell Lymphoma
Anaplastic Lymphoma Kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) is a T-cell non-Hodgkin lymphoma characterised by a chromosomal rearrangement [t(2;5) (p23;q25)] involving the ALK and NPM1 genes on chromosomes 2 and 5 respectively. This translocation generates the NPM-ALK fusion …
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Studying the Transcriptional and Epigenetic Perturbations of Haematopathologies Expressing NPM1-ALK
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase involved in the development of the gut and nervous system, initially cloned from cases of T-cell lymphoma. ALK has been frequently implicated in diverse cancers through oncogenic translocations, mutations, chromosomal inversion, or amplification …