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Showing 1 to 14 of 14 for “"Anaphase-Promoting Complex-Cyclosome"”.
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Regulation of Anaphase Promoting Complex/Cyclosome to Control M Phase Exit
<p>The Anaphase Promoting Complex/Cyclosome (APC/C) is a RING E3 ligase that plays essential roles both within and outside of the cell cycle. At the onset of anaphase, the APC/C targets cyclin B and securin for degradation, initiating chromosome separation and mitotic exit. Regulation of APC/C …
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The developmental role and regulation of the Anaphase-Promoting Complex/Cyclosome in Drosophila meiosis
… driven in part by proteolysis mediated by the Anaphase-Promoting Complex/ Cyclosome (APC/C). During oogenesis of multicellular organisms, molecular control of meiosis has an added complexity because these divisions must be coordinated with the growth and development of the oocyte as well as its …
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A meiosis-specific form of the Anaphase Promoting Complex/Cyclosome regulates the oocyte-to-embryo transition in Drosophila
… irreversible manner. At the heart of this is the Anaphase Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase. The APC/C targets its substrates for degradation, and thus progresses the cell cycle irreversibly forward. Many substrates of the APC/C have been identified in mitosis, but how …
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Design and development of novel antagonists targeting Cdc20, a central regulator of the Anaphase-Promoting Complex/Cyclosome, for the treatment of cancer
… SAC regulator and mitotic protein, binds the Anaphase-Promoting Complex/Cyclosome (APC/C), a complex capable of stipulating protein destruction, regulating its activity and driving cell cycle progression through orderly APC/C substrate degradation. Key oncogenic roles and aberrant expression …
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Mitotic regulators and their effects on Drosophila : chromosome structure during development
… in Drosophila nurse cells, is a subunit of the anaphase-promoting complex/cyclosome. Increasing levels of cyclin B, a known mitotic target of the APC/C, does not alter the timing of the transition, indicating that CYCLIN B is not the only APC/C target at the polyteny-polyploidy transition. In …
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Molecular Mechanisms of Mitotic Checkpoint Complex Assembly onto Kinetochores
… (SAC), activates the mitotic checkpoint complex (MCC), to inhibit the E3 ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C). Inhibition of the APC/C then delays premature chromosome segregation by preventing APC/C-mediated degradation of two key cell cycle regulators, …
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Morphological and Neuroanatomical Changes Associated with the Induction of Neurodegeneration and Life Span Reduction in Drosophila melanogaster by Glia Targeted Expression of Cdh1/Rap/Fzr, An Activator of the Anaphase Promoting Complex
… (Fzr), an activator of the E3 ubiquitin ligase complex: the Anaphase Promoting Complex/Cyclosome (APC/C). APC/C facilitates the cell cycle stage-specific degradation of cyclins and other mitotic regulators, resulting in the inactivation of Cdk (Cyclin Dependent Kinase) complexes, thus promoting …
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Analysis of Aurora B Regulation and Signaling
… is a serine/threonine kinase that functions in a complex with two other chromosomal passenger proteins called INCENP and Survivin. Its function is implicated in a variety of processes related to mitosis, such as chromosome condensation, regulation of arm cohesion, spindle assembly, chromosome …
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Mechanism of APC/C activation and substrate specificity in mitosis
… cycle transitions are strictly controlled by the anaphase-promoting complex/cyclosome (APC/C). The APC/C is an E3 ubiquitin ligase that regulates chromatid segregation at the metaphase to anaphase transition, exit from mitosis and the establishment and maintenance of G1. The APC/C’s catalytic …
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Molecular Mechanisms Involved in Chromosome Segregation
… and assembly of the human CCAN-CENP- ANuc complex, showing that CCAN tightly grips the linker DNA of the CENPANuc. CENP-C emerges as the main recognition protein of the inner kinetochore. CCAN topologically entraps the linker DNA, explaining how it can withstand both pushing and pulling …
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Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins
… PPIs involving two targets, Tankyrase (TNKS) the Anaphase Promoting Complex/Cyclosome (APC/C-Cdc20). TNKS belong to the poly-ADP-ribose polymerases (PARP) family of enzymes that PARylate their substrates, leading to ubiquitination and subsequent degradation. TNKS bind their protein substrates …
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Identification and functional characterisation of novel APC/C interacting proteins
The anaphase promoting complex /cyclosome (APC/C) is a multi-protein E3 ubiquitin ligase complex that regulates cellular proliferation through its ability to target essential cell cycle regulators such as cyclin A, cyclin B, securin and S-phase kinase-associated protein 2 (SKP2) for …
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Characterisation of the KA1 & KA2 domains and interaction with APC/C
… substrates. One important ligase is the anaphase promoting complex/cyclosome (APC/C) which is responsible for faithful segregation of chromosome during mitosis. Failure to regulate this process can lead to aneuploidy, one of the main causes of cancer. It is therefore important to …
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The Multifunctional Kinase Bub1 Acts as a Signaling Hub for the Spindle Checkpoint
… chromatids and the progression from metaphase to anaphase requires the activation of an ubiquitin E3 ligase, anaphase-promoting complex or cyclosome (APC/C). Cdc20 is the mitosis-specific APC/C activator. The spindle checkpoint prevents premature sister chromatids separation by preventing Cdc20 …