Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Analytical sensitivity"”.
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Analytical sensitivity analysis methodology for the co-design of thermal management systems
This thesis presents an analytical sensitivity analysis methodology to be used in a co-design approach to simultaneously optimize plant parameter variables and controller gains. Sensitivity analysis methods are commonly used in system design. The sensitivity of the system output to design variables …
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Efficiency, manufacturability, and modeling challenges in structural design optimization
… design optimization on three topics: semi-analytical sensitivity analysis, design of composite structures fabricated via additive manufacturing, and topology optimization of structures under contact boundary conditions. We first give a general overview and some new developments of the …
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Cell-Free Dna Sequencing In Multiple Myeloma
… value of assessing treatment response with great sensitivity, both in acute and long-term settings. Cell-free DNA, DNA fragments which are released into circulation as a part of normal cellular turnover, is a useful and dynamic biomarker in cancer patients due to the presence of circulating tumor …
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Sample introduction and solvent effects in an argon and helium microwave induced plasma
… both the Ar and He microwave plasmas, decrease analytical sensitivity, and attenuate the energy of the plasma discharge. The conditions under which solvent loading is minimized do not have a significant effect on the operational characteristics of the sample introduction systems, but provide the …
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Automated design of composite plates for improved damage tolerance
… algorithm was used for the weight minimization. Analytical sensitivity derivatives of the SIF, obtained by employing the adjoint variable technique, were used to enhance the computational efficiency of the procedure. Design results for both unstiffened and stiffened plates are presented.
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Studying the Structural Dynamics and Aptamer-Ligand Interactions in the Cocaine-Binding Aptamer through Fluorescence Spectroscopy
… technology since biosensors yield greater analytical sensitivity upon ligand-induced structural changes.
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Advanced finite-element techniques for simulation of composite materials and large-scale scattering problems
… meshes. The fixed mesh nature combined with an analytical sensitivity analysis significantly reduces the computational cost in gradient-based shape optimization. Second, an efficient parallelization strategy is proposed for the domain decomposition based dual-primal finite-element tearing and …
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Validation of Passive Air Sampling Monitors Onboard United States Navy Submarines
… to the passive monitors and improved laboratory analytical sensitivity will likely improve their effectiveness and additional validation testing conducted using the guidelines provided by this study is warranted.</p>
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Crashworthiness Multi-Material Topology Optimization for Minimum Mass
… simulations do not allow for the calculation of analytical sensitivity derivatives required for conventional gradient-based structural optimization strategies. Non-gradient based methodologies for crashworthiness optimization exist in the literature which optimize structures via direct use of …
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A Characterization of Caffeine Imprinted Polypyrrole Electrode
… at different conditions. &#;To determine the Analytical Sensitivity (γ) of the polymeric film at varied conditions. In summary these are conclusions stated: •The thickness of the electrode increased with an increase in the number of pulses. The film thickness increased linearly up to an …
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Reliability-Based Design Optimization of Nonlinear Beam-Columns
… beam-columns under axial compression, the sensitivity of the ultimate strength, structural optimization and reliability analysis using ultimate strength analysis, and Reliability-Based Design Optimization (RBDO) of the nonlinear beam-columns. The ultimate strength analysis is based on …
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The evaluation of an argon and helium highly efficient microwave induced plasma as an element selective detector for packed column super critical fluid chromatography
… determination of the elemental composition of an analytical sample. Although most frequently used to determine the total concentration of a given analyte, atomic spectroscopy may be coupled with a separation technique to aid in the elemental identification of individual species. Recently, …
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Cross-talk-free dual-color fluorescence cross-correlation spectroscopy for high-throughtput screening
… also prepare and process samples prior to the analytical measurement. To achieve the required throughput, we have conducted work directed toward developing a system that provides detection sensitivity at the single-molecule detection (SMD) level. The research was first focused on the …
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Fabrication, design, and analytical applications of nanostructured plasmonic crystals
… which exhibit the great potential for analytical applications. The work presented in this dissertation focused on the enhancement of analytical sensitivity of a new class of bimetallic plasmonic crystal and the development of plasmonic imaging technique for complex biomolecular system …
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Sensitivity Analysis and Optimization of Multibody Systems
… is design optimization for multibody systems. Sensitivity analysis of multibody system dynamics, which is performed before optimization or in parallel, is essential for optimization. Current sensitivity approaches have limitations in terms of efficiently performing sensitivity analysis for …
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Developing Detection Methods for Nitroxyl
… agents against other nitrogen oxides, and/or low sensitivity towards HNO. In this work we have used thiols to efficiently and selectively trap HNO. We then used fluorescence-based detection methods for highly sensitive and selective detection. An in vitro assay was developed for quantifying HNO …
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IGFEM modeling of transverse failure in carbon-epoxy composites and implementation of the IGFEM in Abaqus FEA
… API. This implementation was verified against analytical and conforming mesh solutions.
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The Physical Mechanism of Heat Transfer Augmentation in Stagnating Flows Subject to Freestream Turbulence and Related Studies
… convection were both very close to the predicted sensitivity using a thermal resistance model of the HTHFS. The sensor performance was unaffected by repeated thermal cycling using kiln and torch firing. Finally, the performance of Schmidt-Boelter heat flux sensors were examined in both shear and …
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An evaluation of analytical procedures for detection of drug abuse with particular reference to opiates.
… the alternative injection modes with respect to sensitivity and precision. Using urine samples obtained from volunteers following consumption of legal opiates and also samples from the original screening programme, it is shown that both the normal phase LC method and the method based on CE yield …
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Measurement of calprotectin (S100A8/S100A9) and S100A12 in serum: method development, analytical validation, and clinical application
… and repeat testing procedures, reinforce analytical claim that assay measurement is devoid of uncertainty to justify 'fit for purpose' and confer additional benefit of good reputation to a clinical laboratory. Validation of an assay in serum confirms or disproves kit manufacturer’s …
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