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Showing 1 to 20 of 855 for “"Analogs"”.
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Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs
Prostate cancer is the most common non-skin cancer for men in America. The androgen receptor exerts transcriptional activity and plays an important role for the proliferation of prostate cancer cells. Androgen receptor ligands bind the androgen receptor and inhibit its transcriptional activity …
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Synthesis of Paclitaxel Analogs
… lipopolysaccharide, several C10 A-nor-paclitaxel analogs have been synthesized and their biological activities have been evaluated. In order to reduce the myelosuppression effect of the paclitaxel, several C3â ² and C4 paclitaxel analogs have been synthesized and their biological evaluation have …
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Regioselective Synthesis of Glycosaminoglycan Analogs
… A method that can access GAGs and their analogs with defined structure at relatively large scales will facilitate our understandings of GAG biological roles and biosynthesis modulation. Cellulose is an abundant and renewable natural polymer. Applications of cellulose and cellulose …
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Dipole photonic resonators and analogs of matter
High power RF deflecting cavities have found a wide range of applications which include particle separation, emittance exchange, X-ray pulse compression, temporal beam diagnostics, and crab crossing in colliders. However, conventional deflecting cavities suffer from beam degrading parasitic modes …
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Synthetic Analogs of the Photosynthetic Reaction Center
The bis(porphyrin) subunit has also been incorporated into a triad complex where the bridge between the expected quinone and bis(porphyrin) subunit is a monomer porphyrin. Use of meso-(mesityl) dipyrromethane leads to trans-substituted porphyrin.
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The Synthesis of Cytokinins and Cytokinin Analogs
Made available in DSpace on 2014-12-10T23:01:33Z (GMT). No. of bitstreams: 1 7317363.pdf: 2816632 bytes, checksum: dee8c38eaf8f625452f0d796c0c9096d (MD5) Previous issue date: 1972
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Synthesis and Biological Evaluation of Paclitaxel Analogs
… the paclitaxel-binding site, several fluorescent analogs of paclitaxel were synthesized, and their biological activities have been evaluated. For the investigation of possible synergistic effects, concurrent modifications on selected positions have been performed and their biological evaluation …
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Design, Synthesis and Study of Novel Nucleobase Analogs
… to expand the repertoire of available nucleobase analogs used in the study of nucleic acids. More specifically, we are interested in modification of the nucleobases such that they retain their ability to undergo Watson-Crick base pairing. Moreover, our goal is to modify the nucleobases in order to …
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Active Insulin Analogs That Do Not Require Refrigeration
… techniques to create bioactive insulin analogs that are not susceptible to fibrillation, a temperature sensitive process, and thus do not require refrigeration. Solid phase peptide synthesis techniques and the incorporation of backbone modified amino acids into peptide sequences will be …
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Discriminative stimulus properties of 3-substituent rimonabant analogs
… study from our laboratory investigating analogs of the CB1 antagonist rimonabant revealed that certain alterations in the 3-substituent of rimonabant’s pyrazole core conferred agonist-like properties in the tetrad. Interestingly, these effects were present in CB1 -/- mice, and were not …
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Resveratrol Analogs: Potential Chemopreventive Agents in Breast Cancer
… antioxidants like resveratrol (Res), resveratrol analogs (TIMBD and HPIMBD) and Vitamin C. Resveratrol has been shown to reduce primary tumor growth of xenografts in a nude mouse model. But its clinical applications in prevention of breast cancer are limited because of its lower efficacy in in …
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BOOTSTRAPPING ANALOGS OF THE ONE WAY MANOVA TEST
… Olive (2017abc) bootstrap technique to develop analogs of one way MANOVA test. A large sample theory test has also been developed. The bootstrap tests can have considerable outlier resistance, and the tests do not need the population covariance matrices to be equal. The two sample Hotelling's …
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Anti-tubercular Clofazimine Analogs with Improved Physicochemical Properties
The worldwide incidence of active tuberculosis (TB) infection was reported to be 9.6 million with the disease responsible for 1.5 million deaths in 2014 despite current treatment approaches that require the use of multiple antimycobacterial agents for extended periods of time. Furthermore, the …
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