Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Anaesthetics"”.
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UCTAS : the UCT anaesthetics simulator : simulating the uptake and distribution of halothane
An anaesthetic simulator program that runs on an IBM personal computer system has been developed. The program allows an operator to observe the uptake and distribution of the volatile anaesthetic agent halothane by a standard 75kg patient. The "patient's" breathing is assisted by a ventilator and …
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NMR Studies on Model Membranes. Interaction with Metal Ions, Ionophores and General Anaesthetics
… membrane active compounds such as ionophores, anaesthetics, surfactants and metal ions.<br/><br/>In chapter 1 an introduction to the NMR technique and current progress in the field of model and biological membranes was given. In chapter 2 it was shown that pulsed NMR techniqes gave insight to …
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Electroencephalographic effects of general anaesthetics : a suite of clinical studies and theoretical models
The primary object of this thesis was to investigate aspects of empirically-measured, anaesthesia-induced electroencephalographic (EEG) changes that could be explained by network models of cortical interactions. The thesis consists of a collection of various theoretical and clinical papers in three …
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Intravenous anaesthetics inhibit nicotinic receptor-induced membrane currents and Ca 2+ -transients in rat intracardiac neurons
The effects of intravenous (i.v.) anaesthetics on nicotinic acetylcholine receptor (nAChR)-mediated transients in intracellular free Ca2+ concentration ([Ca2+]i) and currents were investigated in neonatal rat intracardiac neurons using fura-2 photometry and patch-clamp recordings. Extensive …
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The Mechanism of Action of Lidocaine and Levobupivacaine on Human Cardiac Voltage-gated Na<sup>+ </sup>Channels Na<sub>V</sub>1.5
… neurons are the molecular targets for local anaesthetics. However, due to the ubiquity of VGSCs in excitable tissues, they are prone to inhibition by local anaesthetics, including the cardiac NaV1.5 subtype, which is also expressed in metastatic breast and colon cancer cells. The expression …
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Mechanism of anaesthetic activation, combination and antagonism
… of ligands targeting GABAA receptors are general anaesthetics. The effects of anaesthetics on the human body such as immobility, analgesia, amnesia and muscle relaxation are exploited during surgery and are indispensable in modern medicine to allow invasive procedures. Although the binding sites …
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Multi-Nuclear NMR Studies of Phospholipid Membranes and their Interaction with Membrane Active Substances
… phospholipid vesicles by a range of general anaesthetics were investigated using 1H-NMR. Membrane permeability was found to be inhibited by inhalation anaesthetics independently of the channel system or lipid composition used. The results indicated the importance of hydrogen bonding as an …
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A study of the effect of anaesthetic molecules on model membranes formed in surfactant / water mixtures
… the effect of a range of general and local anaesthetics on model membranes, aiming to establish if the addition of anaesthetic promotes changes in the membranes interfacial region or within their internal structure. The models used for biological membranes were simple surfactantiwater …
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Survival after local anaesthetic overdose : a comparison of the success of resuscitation after established cardiotoxicity caused by ropivacaine or bupivacaine
… to review the pharmacology and toxicity of local anaesthetics, particularly highlighting the differences between bupivacaine and ropivacaine and to present an experiment attempting to establish whether ropivacaine is a safer drug, once cardiotoxicity has occurred.
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A Mesoscale Dynamics study of the phases in surfactant-water ternary systems
… of the lamellar phase. However, the addition of anaesthetics and short-chained alcohols, which are small amphiphilic molecules, promote surface curvature, and there is an optimum chain length for maximum stability of the mesh phase. Coulombic interactions, although unsuccessfully modelled with …
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Gas exchange with a reflecting system for inhalational anaesthesia
… and nitrous oxide, but closed to inhalational anaesthetics, was developed. This was achieved by a reflecting filter for inhalational anaesthetics made of active carbon. The principle has been developed into the commersially available Anesthetic Conserving Device (ACD, AnaConDa®).The ACD is a …
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Recent advances in anaesthesia from the point of view of the general practitioner, with special reference to pre-anaesthetic narcosis
… to record my experiences with the older types of anaesthetics, and to compare them with those of recent introduction.
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Improving pain management for children
… in paediatric clinical practice, namely local anaesthetics, opioids, non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol. In addition, control of the stress responses to tracheal intubation and to surgery has been studied with the availability of newer potent short-acting opioid …
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Abstracts of Diploma Theses (2011) for Master’s Degree in Healthcare Management
… ****** QUALITY PERFORMANCE EVALUATION SYSTEM OF ANAESTHETICS AND INTENSIVE CARE DEPARTMENT ****** PR STRATEGY OF THIRD PSYCHIATRIC CLINIC – ST. MARINA HOSPITAL VARNA ****** MARKETING COMMUNICATION STRATEGY OF EYE CLINIC ST. PETKA – VARNA ****** HOUSEHOLDS’ EXPENDITURES ON HEALTH NEEDS ****** …
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Betäubung von Regenbogenforellen (Oncorhynchus mykiss) mit Nelkenöl und BHA – Stressbelastung und Produktqualität
… examination of carcasses and concentration of anaesthetics in the blood. All three methods of anesthesia worked within a limited time, with no animal showing signs of typical behaviour under stress. Blood parameters did give hints for no or very low stress. In the mean of sensory testing a few …
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The Incidence of Postoperative Nausea and Vomiting after Thyroidectomy using Three Anaesthetic Techniques
Introduction: The choice of anaesthetics can affect the incidence of postoperative nausea and vomiting (PONV). This study compared the incidence of PONV in female patients who underwent thyroidectomy with anaesthesia induced by sevoflurane, propofol？ remifenanil or …
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Development of biodegradable implants for sustained drug delivery
… delivery of chemotherapeutics, antibiotics, or anaesthetics. However, they were not prolonged enough for the treatment of chronic diseases (for example human immunodeficiency virus). Polymeric coatings were developed which prolonged the release from these implants and increased their potential …
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A Structural and Computational Study of GABAA Receptor Diversity
… therapeutics, such as benzodiazepines or general anaesthetics. GABAARs assemble from a pool of 19 paralogous genes, each conferring the receptor unique properties, such as ligand binding, gating kinetics or subcellular localization. Yet, the landscape of possible receptor assemblies, their …
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Development of a non-invasive electrophysiological system for measuring the auditory capability of marine animals
… quality data from vertebrates in the absence of anaesthetics or implanted electrodes. The ABR technique was further refined to allow for the recording of evoked potentials in response to either the sound pressure or particle motion component of an acoustic signal, from animals stationed both at …
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