Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"Amyotrophic lateral sclerosis (ALS)"”.
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Mas Receptor Agonism for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a rare, progressive neurodegenerative disease characterized by the loss of motor neurons, leading to complete paralysis and death. As of today, approximately 32,000 people are suffering from ALS within the United States, with a worldwide prevalence reaching …
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INDUCED PLURIPOTENT STEM CELLS (IPSC) TO STUDY PATHOMECHANISMS ASSOCIATED TO AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Amyotrophic Lateral Sclerosis (ALS) is a currently incurable and adult-onset neurodegenerative disease, characterized by the progressive and selective loss of upper and/or lower motor neurons, leading to a relentless and severe muscular atrophy with rapid death of patients, usually due to …
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Investigation of Endogenous Retroviruses in the Pathogenesis of Sporadic Amyotrophic Lateral Sclerosis (ALS) by
… expressed in neurological conditions such as Amyotrophic Lateral Sclerosis. While HERV-K (HML-2) transcripts were reported as elevated in premotor cortex samples from an ALS American cohort by Li et.al. (2015) the RT-qPCR assays performed in this sudy, using the same primers and reaction …
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Data-driven Analysis of Clinical Trials
… combines two studies in the field of clinical trials. The first evaluates the amyotrophic lateral sclerosis (ALS) drug AMX0035 using Bayesian decision analysis (BDA), balancing FDA safety standards with patient needs. This method provides a quantitative way to consider both the patient’s …
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Protein misfolding toxicity and inclusion formation in cellular models of neurodegeneration
… Factor (RGNEF), Matrin3, which are involved in amyotrophic lateral sclerosis (ALS) and polyglutamine (polyQ) expanded huntingtin, which causes Huntington’s disease (HD). Genetic, biochemical, and pathological findings implicate RGNEF and Matrin3 in Amyotrophic Lateral Sclerosis (ALS). In this …
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Amyotrophic Lateral Sclerosis: An Exploration into the SOD1 Protein and a Representative Case Study
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the continual deterioration of upper and lower motor neurons, which invariably leads to death. Like other complex diseases, no particular cause can be attributed to the great majority of ALS cases. Clear …
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The Application of Double Machine Learning Onto Genomics Data Associated with Amyotrophic Lateral Sclerosis
… diagnosis, prevention, and treatment research. Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease for which which there is no cure and relatively little is known about what causes the disease. Previous work has shown certain genes to be associated with ALS and …
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Investigating canine degenerative myelopathy as a disease model of amyotrophic lateral sclerosis for histopathological evidence of dysphagia
… myelopathy (DM), a proposed disease model of amyotrophic lateral sclerosis (ALS). The purpose of our study was to establish a clinicopathological correlation of dysphagia in canine DM. We investigated the brainstem nuclei involved in swallowing in DM and control dogs. Samples were procured …
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Investigation of Riluzole’s Synaptic Protection Mechanism Through HSF1-BDNF Axis
<p>The FDA-approved amyotrophic lateral sclerosis (ALS) drug Riluzole has great potential in treating Alzheimer’s disease (AD) based on promising animal data as well as its known action on modulating synaptic transmission. However, its detailed mechanism of action is not fully understood. Here, we …
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Biophysical Characterization of the ALS-Linked Protein TDP-43; and Genetic and Small Molecule Rescues from Its Cytotoxicity
… ribonucleic acids (mRNA) in human cells but is also aggregation prone and has been implicated in amyotrophic lateral sclerosis (ALS). The structure of this multi-domain protein remains unknown, as each domain is linked by a disordered linker region. The C-terminal domain (CTD) is largely …
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Exploring SOD1 electron transfer, heterodimerization, and hetero-amyloid formation.
… metalloenzyme that regulates superoxide radicals. Because SOD1 is a long-lived protein, it contains an intrinsic molecular clock, deamidation, that accumulates over time. Misfolding and aggregation of SOD1 have been linked to neurodegenerative diseases such as amyotrophic lateral sclerosis …
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“Biomarkers” for Translational Success in Neurodegenerative Diseases: A Comparative Analysis of the Research to Practice Trends in Breast Cancer and ALS to Identify Systematic Indicators of Translational Success
… and translation between breast cancer and Amyotrophic Lateral Sclerosis (ALS), we identified eight critical indicators for successful translation in heterogeneous diseases. Among these, two stand out: (1) the identification of critical molecular pathways relevant to the disease and (2) the …
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TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor
… of neurodegenerative disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). TDP-43 is an RNA/DNA-binding protein implicated in transcriptional and post-transcriptional regulation. Recent work also suggests …
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Relationship Between TDP-43 Toxicity and Aggregation in Saccharomyces Cerevisiae
… as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis (ALS). These neurodegenerative diseases share a common pathology in that all include accumulation of insoluble protein aggregates in the brain. TAR-DNA-binding protein (TDP-43) is the major component found in the …
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Estrogen's Effects on Oxidative Stress Levels in Glial Cells
… depressive disorders, Alzheimer’s disease, and Amyotrophic Lateral Sclerosis (ALS). Previous research indicates that some estrogens may have a positive effect on neuron and astrocyte viability. Estrogens’ effects on the brain are of interest as estrogens are commonly prescribed as hormone …
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Lost in Translation: Variations in WNT Signaling and Other Translational Changes in a Drosophila Model of ALS
Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative disease inwhich 97% of patients exhibit cytoplasmic aggregates containing the RNA binding protein TDP- 43, referred to as TDP-43 pathology. My project focused on understanding how TDP-43 pathology modifies …
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