Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 180 for “"Amyotrophic Lateral Sclerosis"”.
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Profiling neuroinflammation in amyotrophic lateral sclerosis
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease primarily characterised by progressive loss of motor neurons. ALS is highly heterogeneous and exists on a clinical and pathogenetic spectrum with frontotemporal dementia (FTD); those anywhere on this spectrum are said to …
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Characterization of Peripherin Isoforms in Amyotrophic Lateral Sclerosis
… and in the devastating neurodegenerative disease amyotrophic lateral sclerosis (ALS). Interestingly, peripherin overexpressing transgenic mice succumb to motor neuron disease with pathological hallmarks reminiscent of those found in ALS. Pathological peripherin abnormalities occur with high …
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New Therapeutic Strategies for Amyotrophic Lateral Sclerosis Treatment
Amyotrophic lateral sclerosis (ALS) is characterized by progressive dysfunction and degeneration of motor neurons in cerebral cortex, brain stem and spinal cord. Degeneration of motor neurons causes muscle weakness and respiratory paralysis, leading to decease of ALS patients. Approximately 10% of …
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Neuromuscular Ultrasound for the Evaluation of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes progressive loss of motor neurons, which results in weakness, respiratory compromise, and typically death within 5 years of disease onset. The diagnosis is often delayed up to a year from the time of onset because it is …
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Development of novel diagnostics and therapeutics for amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with diagnostics and treatments that are ineffective at stopping the progression. This thesis examines new ways of both diagnosing and treating ALS, including 1) a gadolinium tetanus toxin C fragment (Gd-TTC) biomarker for axonal …
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Acoustic features of impaired articulation due to amyotrophic lateral sclerosis
… bulbar motor deterioration resulting from amyotrophic lateral sclerosis (ALS) leads to speech impairment. Despite the devastating consequences of speech impairment to life quality, few options are available to objectively assess speech motor involvement. The overarching goal of this …
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Apathy, Depression, and Emotional Lability in Patients with Amyotrophic Lateral Sclerosis
… and behavioral impairment in some patients with amyotrophic lateral sclerosis (ALS) is now well-known. However, the prevalence of behavioral impairment and the relationship between behavioral and cognitive impairment in ALS is not fully understood. This study is the first to examine …
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Mas Receptor Agonism for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a rare, progressive neurodegenerative disease characterized by the loss of motor neurons, leading to complete paralysis and death. As of today, approximately 32,000 people are suffering from ALS within the United States, with a worldwide prevalence reaching …
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Functional analysis of amyotrophic lateral sclerosis mutations using Drosophila cell culture models
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterised by the degeneration of motor neurons, resulting in paralysis and eventually death. This thesis examined the molecular mechanisms of ALS by analysing three key ALS-associated genes: FUS, SOD1, and TDP43, …
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Human Stem Cells for Modeling Amyotrophic Lateral Sclerosis Disease Mechanisms and Modifiers
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor system. Although ALS has been extensively studied in post-mortem patient samples and animal models, there are currently no very effective treatments and there is no cure. One reason for the lack of treatment …
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Investigating the aggregation of TDP-43 in models of Amyotrophic Lateral Sclerosis
… inclusions characteristic of most forms of amyotrophic lateral sclerosis (ALS) and ubiquitin-positive frontotemporal lobar degeneration (FTLD). Normally a nuclear protein, TDP-43 translocates to the cytoplasm and forms pathogenic inclusions in the disease-state, where the protein is often …
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Study of trace and minor elements in ALS (amyotrophic lateral sclerosis) patients
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1994.
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Speech Network Regional Differences in Bulbar Amyotrophic Lateral Sclerosis: Neuroimaging and Neuropathology Investigations
… the neural anatomical underpinnings of bulbar Amyotrophic Lateral Sclerosis (ALS) with a particular focus on the cortical speech network (SpN). The work has significant impact on ALS subtyping which is crucial for understanding disease pathogenesis, and clinical implications for diagnosis, …
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VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS
… our previous studies on a zebrafish model of Amyotrophic Lateral Sclerosis, that express the mutant G93R form of the superoxide dismutase 1 (SOD1) enzyme, show that alteration in the INaP of spinal inter- and moto- neurons induced neuron hyperexcitability that finally leads to hyperactive …
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Amyotrophic Lateral Sclerosis: mechanism behind mutant SOD toxicity and improving current therapeutic strategies
Amyotrophic Lateral Sclerosis (ALS) is an always lethal motor neuron disease with unknown pathogenesis. Inhibitors of the molecular chaperone heat shock protein 90 (Hsp90) have limited neuroprotection in some models of motor neuron degeneration. However the direct effect of Hsp90 inhibition on …
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Amyotrophic Lateral Sclerosis: An Exploration into the SOD1 Protein and a Representative Case Study
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the continual deterioration of upper and lower motor neurons, which invariably leads to death. Like other complex diseases, no particular cause can be attributed to the great majority of ALS cases. Clear …
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INDUCED PLURIPOTENT STEM CELLS (IPSC) TO STUDY PATHOMECHANISMS ASSOCIATED TO AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Amyotrophic Lateral Sclerosis (ALS) is a currently incurable and adult-onset neurodegenerative disease, characterized by the progressive and selective loss of upper and/or lower motor neurons, leading to a relentless and severe muscular atrophy with rapid death of patients, usually due to …
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