Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Amyloid-β oligomers"”.
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Synaptic dysfunction, tau spreading, and cognitive resilience through the lens of tau oligomers in Alzheimer’s disease and related dementias
… vulnerability. In Chapter 2, we show that amyloid-β oligomers (AβO) promote the binding and internalization of tauO into human synaptosomes via specific membrane protein pathways, suggesting a mechanism for Aβ-facilitated trans-synaptic spread of tau pathology. Chapter 3 reveals that …
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Macromolecular design for modulation of amyloid fibrillar assembly
Amyloid protein aggregation is notorious for its association with many devastating human diseases such as AIDS, cancer, Alzheimer's disease, and prion diseases. Scientists have made significant progress in designing modulators which prevent amyloid formation and provide potential therapeutics for …
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Investigating the effects of calreticulin and beta-galactosidase on microglial functions and neuronal loss
… and neurodegeneration. The aggregation of amyloid-β to form oligomers and insoluble amyloid plaques in the brain is a hallmark of AD. Amyloid-β can be directly neurotoxic and induce pro-inflammatory activation of microglia, which may contribute to neurodegeneration. Molecular chaperone …
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Use solid-state NMR to study the molecular structures of disease-associated peptide aggregates
… and Dr. Stagg to investigate the 150 kDa Amyloid-β(1-42) (Aβ) oligomers associated with Alzheimer’s disease. A domain-swapped four-fold symmetric structural model of the oligomer was proposed based on NMR data and cryogenic electron microscopy (cryo-EM) 2D classification. The novel …