Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Amyloid-β Precursor Protein"”.
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Ectodomain Mutations Alter the Proteolysis of the Amyloid-β Precursor Protein (APP)
… Americans. In AD patients there is a buildup of amyloid plaque in the brain, which contributes to AD symptoms. The main component of plaques is Amyloid-β (Aβ), a 40-42 length peptide formed from Amyloid-β Precursor Protein (APP) proteolysis. APP proteolysis can result in either anti-trophic or …
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Fibrin Formation and Dissolution in the Progression of Amyloid-Beta Pathology in Alzheimer's Disease
… a major cause of AD is the production of the amyloid-β (Aβ) peptide, which is proteolytically derived from the amyloid-β precursor protein. The Aβ peptide can oligomerize and be deposited as extracellular plaques in the brain and blood vessels, but the mechanism of how it leads to neuronal …
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Apolipoprotein E4 and SirT1 Interaction in Alzheimer’s Disease
… still unknown. Εpsilon 4, an allele of apolipoprotein E (ApoE4), is currently the most important risk factor for Alzheimer’s disease. Individuals that inherit two copies of the ApoE ε4 allele have an approximately ten to thirty times increased risk of developing AD in comparison to persons not …