Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"Amyloid-β"”.
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Nanoscale imaging and characterisation of Amyloid-β
… methods have been applied to the study of the amyloid peptide implicated in the pathogenesis of Alzheimer’s disease (AD). Amyloid-β (Aβ) undergoes a hierarchy of aggregation following a structural transition making it an ideal subject of studying with SPM. The application of SPM based …
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Growth and Toxicity of Amyloid β Polymorphs
… is the accumulation of the protein fragment amyloid β (Aβ) into soluble aggregates or insoluble β-sheet-rich fibrils and plaques in the brain. Limited success in targeting these fibrils and plaques stems from a lack of understanding of the intricate process of Aβ fibrillization. We …
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Photoactive metal complexes for studying amyloid-β aggregates
Amyloid-β is a short peptide produced in the brain, which self-assembles into large aggregates. This process is known to be involved in the development of Alzheimer’s disease. Because of this link, there is a significant interest in developing probes that are capable of sensing and reporting on …
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The Conformational Dynamics of the Polymorphic Amyloid β Protofilaments
… focused on understanding the interaction between amyloid β (Aβ) protofilaments and model bilayers.|The community, as a whole, does not know the 3D structure of the Aβ protofilament. Therefore, we studied two polymorphic Aβ (9-40) structures [1] as likely conformations. We relaxed the structures …
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Investigating the Phase Behaviour of the Alzheimer’s Amyloid-β Peptide
… aggregation of proteins. The aggregation of the amyloid-β peptide (Aβ) into amyloid plaques is a hallmark in the aetiology of AD. However, the exact nature of the association between AD and Aβ aggregation is not fully understood. Quite generally, the aggregation of proteins into amyloid fibrils …
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Amyloid β Aggregation is Coupled to Cellular Metabolism and Intramitochondrial Proteostasis
… rhoA and Casein kinase I isoform alpha, form amyloid structures in a Caenorhabditis elegans model, with ageing. Using this system, we monitor the aggregation of the Amyloid β (1-42) (Aβ42) protein involved in AD, and we show that a new anti-aggregation compound, MJ040X, can suppress Aβ42 …
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Ectodomain Mutations Alter the Proteolysis of the Amyloid-β Precursor Protein (APP)
… Americans. In AD patients there is a buildup of amyloid plaque in the brain, which contributes to AD symptoms. The main component of plaques is Amyloid-β (Aβ), a 40-42 length peptide formed from Amyloid-β Precursor Protein (APP) proteolysis. APP proteolysis can result in either anti-trophic or …
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The Identification and Development of Small Molecule Inhibitors of Amyloid β Aggregation
Amyloid $\beta$ (1-42) (A$\beta$42) is a seminal neuropathic agent in Alzheimer’s disease (AD), a multifaceted neurodegenerative disorder for which no preventative measures or disease modifying therapies currently exist. Aggregation of this peptide plays a key role in the synaptic dysfunction and …
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Cerebrovascular and Neuronal Cellular Consequences of Amyloid-β Induced Nuclear Factor-κB Activation
… extracellular plaques are composed of aggregated amyloid-β protein (Aβ), which is widely believed to be the underlying cause of the disease. Mounting evidence suggests the small, soluble aggregates of Aβ induce the progressive neurodegeneration observed in AD patients. AD patients also display …
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Structural Characterization of Plaque Seeded Amyloid-β Fibrils by Magic Angle Spinning NMR
Accumulation of plaques consisting of amyloid fibrils of the peptide amyloid-β (Aβ) in the brain is one of the hallmarks of Alzheimer’s disease (AD). Aβ is prone to polymorphism and the structure of fibrils is sensitive to the conditions under which they are formed. The two dominant forms of Aβ are …
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Lipid raft signaling in cofilin-actin rod formation induced by amyloid-β and TNFα
… stresses, excitotoxic levels of glutamate, and amyloid beta treatment. Cofilin is an F-actin assembly regulatory protein critical to various actin-dependent processes, such as cytokinesis, cell migration, and neurite formation. Overexpression or hyperactivation (excessive dephosphorylation) of …
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Propagation of Oligomeric α-Synuclein and Amyloid-β: Implications for Parkinson's and Alzheimer's Diseases
<p>The aggregation of amyloidogenic proteins is a critical event in the pathology of a variety of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). The proteins <strong>α</strong>-synuclein (<strong>α</strong>S) and amyloid-<strong>β …
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Vitamin B12 impacts amyloid-β induced proteotoxicity by regulating the methionine/s-adenosylmethionine cycle
… factors contribute to AD pathogenesis including amyloid-beta (Aβ) deposition, energy crisis, and oxidative stress. Here I used a transgenic Aβ expressing Caenorhabditis elegans to define the impact of diet on Aβ proteotoxicity. Caenorhabditis elegans are free-living, non-parasitic nematodes that …
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Amyloid-β and amyloid associated proteins in the pathology and diagnosis of Alzheimer's disease
Contains fulltext : 156484.pdf (Publisher’s version ) (Open Access)
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Applications of Focused Ultrasound for Reducing Amyloid-β in a Mouse Model of Alzheimer's Disease
… that FUS can facilitate a rapid reduction in amyloid-β peptide (Aβ) pathology in a mouse model of AD. Firstly, FUS was used to enhance delivery of an antibody directed against Aβ, which aggregates and forms extracellular plaques. FUS mediated the delivery of antibodies to the targeted right …
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The novel phosphorylation site PLCγ2 Y1217 facilitates the TREM2 amyloid-β sensing pathway in microglia
… manifests itself in the brain as aggregations of amyloid-β containing extracellular plaques and intracellular aggregates of hyperphosphorylated tau. The majority of AD cases are sporadic, have no clear single cause and have been termed as late-onset Alzheimer’s disease (LOAD), where symptoms …
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Study of Polyphenols and Naphthalimide Analogs As Inhibitors of Amyloid- β Protein Aggregation In Alzheimer'S Disease
… progression of this disease. The deposition of amyloid plaques in AD brains exhibits a causative link with this disease. Amyloid plaques are primarily comprised of aggregates formed by the amyloid- β proteins (A β). Inhibition of the formation of Aβ aggregates or disrupting …
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Structural Studies of Amyloid-β Fibrils using Magic Angle Spinning Nuclear Magnetic Resonance and Dynamic Nuclear Polarization
… last two decades has seen a rise in studies of amyloid fibrils, which have been implicated in many diseases. In particular, amyloid-β is a consistent feature in Alzheimer’s disease, with over 6 million patients in the US diagnosed to date. The first part of this thesis details the pathway to …
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