Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"Amyloid precursor protein (APP)"”.
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Investigating KCC2 activity in Amyloid Precursor Protein (APP) associated Alzheimer’s Disease
… the hallmarks of AD is the formation of sticky protein clumps in the brain known as amyloid-beta (Aβ) plaques, which are formed from specific fragments of the amyloid precursor protein (APP). The intact form of APP is essential for synaptic function; however, much remains to be explored …
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Sodium dichloroacetate (DCA) impairs β-secretase-mediated proteolysis of the alzheimer's disease amyloid precursor protein (APP)
… (AD) is caused by the accumulation of neurotoxic amyloid-beta (Aβ)-peptides in the brain. These peptides result from the amyloidogenic cleavage of the amyloid precursor protein (APP) by y-secretase yielding soluble APPbeta (sAPPβ) and a membraneassociated C-terminal fragment, C99. The latter …
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Studies of the cell biological function of the Amyloid Precursor Protein (APP) family in Drosophila melanogaster and mammals
… is pathologically characterized by extracellular Amyloid plaques and intracellular neurofibrillary tangles are the main pathological features of AD. Amyloid-beta, the main protein constituent of Amyloid plaques, is derived from the Amyloid Precursor Protein (APP) by proteolytic processing. APP is …
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DFer Protein-Tyrosine Kinase : its involvement in the Amyloid Precursor Protein (APP)-induced blistered wing phenotype and its functional characterization in Drosophila melanogaster
Das “Amyloid Precursor Protein” APP ist das Vorläuferprotein des A?-Peptides, welches als Bestandteil der amyloiden Plaques im Gehirn von Alzheimer Patienten auftritt. Obwohl die Entstehung von A? durch die proteolytische Spaltung von APP sehr gut untersucht ist, ist die physiologische Funktion von …
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Untersuchung zur intrazellulären Ca 2+ -Homöostase an hippokampalen Neuronen von PS1- und App-Maus-Mutanten
… den Genen Presenilin 1 und 2 (PS1, PS2) sowie im Amyloid-Precursor-protein (App)gehen mit der autosomal-dominant vererbten Alzheimer Krankheit einher. In neuronalen Zellen von Mäusen, die eine PS1-Mutation tragen, löst eine derartige Mutation eine verstärkte Ca 2+ -Freisetzung aus dem …
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Modeling Alzheimer's Disease Using CRISPR/CAS9 Gene Editing and Induced Pluripotent Stem Cells Reveals Conserved Cellular Mechanisms
… from genetic mutations in three key genes: amyloid precursor protein (APP), and two APP processing-related genes (presenilin-1 (PSEN1), and presenilin-2 (PSEN2)), supporting the theory that altered APP metabolism is a central cause of AD. However, which product of APP metabolism is causal …
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Endocytic Trafficking of The Amyloid Precursor Protein In Rat Cortical Neurons
<p>Amyloid-beta (Aβ) aggregation and deposition into extracellular plaques is a hallmark of the most common forms of dementia, including Alzheimer’s disease. The Aβ-containing plaques result from pathogenic cleavage of amyloid precursor protein (APP) by secretases resulting in intracellular …
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Genetic Reduction of Cholesterol Synthesis in the Mouse Brain Does Not Affect Amyloid Formation in an Alzheimer’s Disease Model, but Does Extend Lifespan
… content or synthesis affect the cleavage of amyloid precursor protein (APP) to amyloidogenic peptides characteristic of Alzheimer’s disease (AD). To determine whether a decrease in cholesterol synthesis would affect APP processing in vivo, we crossed cholesterol 24-hydroxylase knockout (KO) …
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Hiv And Antiretrovirals In The Central Nervous System: Molecular Mechanisms Of Cognitive Impairment
… neuropathogenesis. First, we showed that β-site amyloid precursor protein cleaving enzyme 1 (BACE1), which may play a role in the onset and progression of Alzheimer’s Disease, was both increased in HIV+ patient brains and required for HIV-associated neurotoxicity in vitro. The BACE1 cleavage …
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Determining the mechanism of dichloroacetate-regulated processing of the Alzheimer’s disease-related amyloid precursor protein
… by the accumulation in the brain of ‘sticky’ protein fragments called amyloid beta (A)-peptides. These fragments are formed through the proteolytic cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. However, in an alternate non-amyloidogenic pathway, α-secretase (ADAM10) …
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Lipid Regulation as a Critical Factor in the Development of Alzheimer's Disease
… two decades, researchers have been led by the amyloid cascade hypothesis, which assumes that accumulation of the amyloid peptide Aβ, derived by proteolytic processing from the amyloid precursor protein (APP), is the key pathogenic trigger in AD. To date, therapies have largely focused on …
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Overexpression of Amyloid Precursor Protein Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptosis Pathway
… chromosome 21. Within chromosome 21 is the gene, amyloid precursor protein (APP). Proteolysis of APP into toxic and aggregate-prone, beta-amyloid fragments underlies the pathophysiology of Alzheimer's disease (AD). Individuals with DS develop the neuropathology that can be diagnosed as AD; …
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Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis
The presenilin proteins (presenilin 1 and presenilin 2) were identified in mutagenesis screens causing the early onset forms of familial Alzheimer’s disease (FAD) in 1995. Subsequently characterized as the catalytic subunits of the γ-secretase protease complexes, the presenilins are responsible for …
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The role of the E2 copper binding domain in the cell biology of the amyloid precursor protein
… by the accumulation, in the brain, of neurotoxic amyloid beta-(Aβ) peptides. These peptides are generated from the amyloid precursor protein (APP) via the amyloidogenic proteolytic pathway which also leads to the formation of soluble APP beta (sAPPβ). Alternatively, APP can be cleaved by the …
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A molecular analysis of the relation between TDP-43 and tau pathology
Tau is a microtubule associated protein found in inclusions in tauopathies including Alzheimer's disease. One known cause of neurodegeneration is an excess of exon 10 inclusion in tau mRNA which is caused by several mutations in the MAPT gene, encoding tau. Processing of the Amyloid Precursor …
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Neurotoxicity of environmental pollutants
… of these chemicals, at low concentrations had amyloidgenic effects causing the cleavage amyloid precursor protein (APP) into Beta-amyloid (Aβ) and could therefore be implicated in Alzheimer‟s disease (AD).
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Apolipoprotein E4 and SirT1 Interaction in Alzheimer’s Disease
… still unknown. Εpsilon 4, an allele of apolipoprotein E (ApoE4), is currently the most important risk factor for Alzheimer’s disease. Individuals that inherit two copies of the ApoE ε4 allele have an approximately ten to thirty times increased risk of developing AD in comparison to persons not …
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Regulation of biochemical pathways involved in neurodegeneration
… of how to treat it. Misprocessing of the amyloid precursor protein (APP) in the brains of AD patients leads to accumulation of the amyloidogenic peptide AD. A soluble APP fragment (APPS) is formed when APP is cleaved within the AP region, thereby preventing AP formation. Activation of …
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The hypothalamic role of BACE1 in energy homeostasis
… for Alzheimer’s disease (AD).<br/>The β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is critically involved in AD development, cleaving the amyloid precursor protein (APP) to generate amyloid-β (Aβ), which drives progression of the hallmark pathologies of AD. Consequently, higher …
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Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans
… U.S. AD is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. The b-amyloid peptide is the major component of the plaques and is produced as a cleavage byproduct of the amyloid precursor protein (APP). APP family proteins are present in mammals and the …
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