Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"Amyloid precursor protein"”.
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Processing of Alzheimer's amyloid precursor protein in cultured cells.
The deposition in the brain of the 4 kDa beta-amyloid peptide (betaA4), from amyloid precursor protein (APP), is a key pathology in Alzheimer's disease (AD). The single APP gene is spliced to give 3 major isoforms. In the majority of body tissues, the most common APP isoforms are APP[751] and …
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Amyloid precursor protein subtypes and secretases implicated in Alzheimer's disease.
… disorder Alzheimer disease (AD) however several proteins have been implicated.Eight proteins that have been implicated in AD have been mapped across seven regions of non-human primate brain tissue from a Macaca fascicularis in this study: APP[770]; APP[751]; APP[695]; ADAM 9, 10 and 17 as …
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Investigating KCC2 activity in Amyloid Precursor Protein (APP) associated Alzheimer’s Disease
… the hallmarks of AD is the formation of sticky protein clumps in the brain known as amyloid-beta (Aβ) plaques, which are formed from specific fragments of the amyloid precursor protein (APP). The intact form of APP is essential for synaptic function; however, much remains to be explored …
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Endocytic Trafficking of The Amyloid Precursor Protein In Rat Cortical Neurons
<p>Amyloid-beta (Aβ) aggregation and deposition into extracellular plaques is a hallmark of the most common forms of dementia, including Alzheimer’s disease. The Aβ-containing plaques result from pathogenic cleavage of amyloid precursor protein (APP) by secretases resulting in intracellular …
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Calcium- and tyrosine phosphorylation-dependent mechanisms of amyloid precursor protein processing
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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Cellular Trafficking and Processing Pathways of the Alzheimer β/A4 Amyloid Precursor Protein
<p>Extracellular deposition of the β/A4 amyloid peptide is a characteristic feature of the brain in patients with Alzheimer disease. β/A4 amyloid is derived from the integral membrane amyloid precursor protein (APP). Secreted truncated forms of APP found in blood plasma and cerebrospinal fluid …
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The role of phospholipase D1 in trafficking and processing of amyloid precursor protein
… lipids control the trafficking and processing of amyloid precursor protein (APP) with major implications for pathological and behavioral manifestations associated with Alzheimer's disease (AD). One such lipid is phosphatidic acid (PA), which mediates membrane trafficking and is produced by a …
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An Investigation into the Intracellular Trafficking and Processing Pathways of Amyloid Precursor Protein
Amyloid precursor protein (APP) is a type-I membrane-spanning protein, believed to be central to Alzheimer’s disease (AD) pathology. It undergoes a complex intracellular trafficking and processing itinerary to produce toxic amyloid-β peptides that accumulate in extracellular plaques in the brains …
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Investigating the Role of the Amyloid Precursor Protein in the Pathogenesis of Alzheimer's Disease
… from the accumulation and deposition of the amyloid-β peptide (Aβ) and the aggregation of hyperphosphorylated tau protein, respectively. Aβ is formed upon sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases and is secreted extracellularly. The accumulation of …
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Determining the mechanism of dichloroacetate-regulated processing of the Alzheimer’s disease-related amyloid precursor protein
… by the accumulation in the brain of ‘sticky’ protein fragments called amyloid beta (A)-peptides. These fragments are formed through the proteolytic cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. However, in an alternate non-amyloidogenic pathway, α-secretase (ADAM10) …
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Overexpression of Amyloid Precursor Protein Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptosis Pathway
… chromosome 21. Within chromosome 21 is the gene, amyloid precursor protein (APP). Proteolysis of APP into toxic and aggregate-prone, beta-amyloid fragments underlies the pathophysiology of Alzheimer's disease (AD). Individuals with DS develop the neuropathology that can be diagnosed as AD; …
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The Processing of Amyloid Precursor Protein in the Central Nervous System of Humans and Rhesus Macaques
… of a genetic mutation in one of three genes: Amyloid Precursor Protein: APP), Presenilin-1: PSEN1), or Presenilin-2: PSEN2). Mutation carriers will generally notice cognitive decline starting at a relatively young age, anytime between their 30s-50s, and eventually succumb to this early-onset …
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Sodium dichloroacetate (DCA) impairs β-secretase-mediated proteolysis of the alzheimer's disease amyloid precursor protein (APP)
… (AD) is caused by the accumulation of neurotoxic amyloid-beta (Aβ)-peptides in the brain. These peptides result from the amyloidogenic cleavage of the amyloid precursor protein (APP) by y-secretase yielding soluble APPbeta (sAPPβ) and a membraneassociated C-terminal fragment, C99. The latter …
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Role Of The Alzheimer's Amyloid Precursor Protein In High Fat Diet Induced Obesity And Regulating Macrophage Phenotype
<p>Amyloid precursor protein (APP) derived amyloid beta peptides have been extensively investigated in Alzheimer's disease pathology of the brain. However, the function of full length APP in the central nervous system remains unclear. Even less is known about the behavior of this ubiquitously …
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The role of the E2 copper binding domain in the cell biology of the amyloid precursor protein
… by the accumulation, in the brain, of neurotoxic amyloid beta-(Aβ) peptides. These peptides are generated from the amyloid precursor protein (APP) via the amyloidogenic proteolytic pathway which also leads to the formation of soluble APP beta (sAPPβ). Alternatively, APP can be cleaved by the …
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Studies of the cell biological function of the Amyloid Precursor Protein (APP) family in Drosophila melanogaster and mammals
… is pathologically characterized by extracellular Amyloid plaques and intracellular neurofibrillary tangles are the main pathological features of AD. Amyloid-beta, the main protein constituent of Amyloid plaques, is derived from the Amyloid Precursor Protein (APP) by proteolytic processing. APP is …
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New Insights Regarding the Intracellular Effects, Trafficking, and Quality Control of the Amyloid Precursor Protein: Implications for Alzheimer’s Disease Pathogenesis
… PSEN1 and PSEN2, which encode the presenilin proteins, and APP, which encodes the amyloid precursor protein (APP). Several hypotheses exist for the pathogenesis of AD. According to the amyloid cascade hypothesis, AD pathogenesis is associated with a series of molecular events which leads to …
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DFer Protein-Tyrosine Kinase : its involvement in the Amyloid Precursor Protein (APP)-induced blistered wing phenotype and its functional characterization in Drosophila melanogaster
Das “Amyloid Precursor Protein” APP ist das Vorläuferprotein des A?-Peptides, welches als Bestandteil der amyloiden Plaques im Gehirn von Alzheimer Patienten auftritt. Obwohl die Entstehung von A? durch die proteolytische Spaltung von APP sehr gut untersucht ist, ist die physiologische Funktion von …
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