Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Amyloid peptide"”.
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Angiotensin-converting enzyme cleavage of the Alzheimer's beta-amyloid peptide
… it has been shown that ACE hydrolyses the amyloid beta (Aβ) peptide, the putative causative agent of AD. This study aimed to investigate the molecular basis of ACE hydrolysis of Aβ by determining : 1) the kinetic parameters of five different forms of human ACE with various N-terminal …
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The effects of catalase and kisspeptin overexpression on amyloid peptide toxicity
Amyloid β (Aβ) is the major component of the senile plaques in Alzheimer’s disease (AD). The mechanism underlying cell death in AD includes oxidative stress, apoptosis, impaired mitochondrial function and receptor mediated effects. Compounds that specifically bind to Aβ are neuroprotective. …
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Spins, peptides, and Alzheimer's disease : solid-state nuclear magnetic resonance investigations of amyloid peptide conformation
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Investigating the process of fibril formation of the Iowa mutant of the Alzheimer's peptide
… study is to determine how the length of the beta-amyloid peptide, the specific region of the peptide, and a single point mutation affect the behavior of Alzheimer’s beta-amyloid. The beta-amyloid peptide, which is a 40 residue peptide that has been implicated as a potential cause of Alzheimer’s …
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Role of MOA-1, an Anti-phosphatase, and APL-1, an APP-related Protein, in Morphogenesis and Mating Behavior in Caenorhabditis elegans
… by an accumulation of extracellular beta-amyloid peptide plaques and intracellular neurofibrillary tangles in the brain. The beta-amyloid peptide is derived from a larger precursor protein, the amyloid precursor protein (APP). Mutations in APP have been correlated with Alzheimer's disease. …
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Identification of HIV protease mutants with improved specificities toward an Alzheimer's Disease associated peptide sequence
… specificities and activities toward an octapeptide taken from the beta-amyloid peptide (Abeta) implicated in Alzheimer's Disease. Quantitative Western blotting of E. coli extracts revealed approximately 20- and 30-fold increases in proteolytic specificity and activity, respectively, toward …
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A study of the elongation of fibrils of the Alzheimer's amyloid beta protein with a coarse-grained force field
… research points to a small protein, the beta-amyloid peptide (Abeta), as the first suspect. Ab chains are present in the brains of healthy individuals, but in AD patients, they associate and form clumps that deposit outside neurons, and are believed to trigger the disease. In this …
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Lipid Regulation as a Critical Factor in the Development of Alzheimer's Disease
… two decades, researchers have been led by the amyloid cascade hypothesis, which assumes that accumulation of the amyloid peptide Aβ, derived by proteolytic processing from the amyloid precursor protein (APP), is the key pathogenic trigger in AD. To date, therapies have largely focused on …
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Synthesis And Characterization Of New Gd3+-Containing Complexes As Potential Targeted Contrast Agents For Magnetic Resonance Imaging
… research described in this thesis, myelin and Β-amyloid aggregates were selected as targets because they are important in diagnosing neurological diseases. The myelin-targeted complexes were designed to mimic the structural features of a known myelin-specific histology stain, and ex vivo …
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Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans
… U.S. AD is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. The b-amyloid peptide is the major component of the plaques and is produced as a cleavage byproduct of the amyloid precursor protein (APP). APP family proteins are present in mammals and the …
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Recombinant production of Aβ1-42 peptide and analysis of interactions between Aβ1-42 and Peptide Inhibitor NanoParticles (PINPs) developed as a potential novel treatment for Alzheimer’s Disease
… addressed two main aims relating to the Aβ1-42 peptide – widely demonstrated to play a key role in the pathogenesis of Alzheimer’s Disease (AD). Aβ1-42 is an amyloid peptide that readily self-associates forming neurotoxic aggregates. With the primary risk factor for AD being age, and ageing …
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The Advancement of Mass Spectrometry-based Hydroxyl Radical Protein Footprinting: Application of Novel Analysis Methods to Model Proteins and Apolipoprotein E
… we find by FPOP that ApoE interacts with beta-amyloid peptide 1-42 at a specific site in its N-terminal domain.
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Effects Of Altering The Peroxisomal Redox State In Models Of Degenerative Disease
… to enter cells by virtue of a cell penetrating peptide. Once inside, presumably mediated by an endocytic event, it is directed to the peroxisome via its peroxisomal targeting signal, SKL, and metabolizes H2O2 within the organelle and elsewhere in the cell.</p> <p>In conditions where H2O2 and …
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Cellular Trafficking and Processing Pathways of the Alzheimer β/A4 Amyloid Precursor Protein
<p>Extracellular deposition of the β/A4 amyloid peptide is a characteristic feature of the brain in patients with Alzheimer disease. β/A4 amyloid is derived from the integral membrane amyloid precursor protein (APP). Secreted truncated forms of APP found in blood plasma and cerebrospinal fluid …
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Nanoscale imaging and characterisation of Amyloid-β
… methods have been applied to the study of the amyloid peptide implicated in the pathogenesis of Alzheimer’s disease (AD). Amyloid-β (Aβ) undergoes a hierarchy of aggregation following a structural transition making it an ideal subject of studying with SPM. The application of SPM based …
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Cofilin-actin rods: quantification and comparison to tau pathology in a human longitudinal aging study and developing probes to measure localization and activity of NADPH oxidase 2, a component of the prion-dependent rod inducing pathway
The presence of extracellular amyloid plaques composed mainly of fibrils of the β-amyloid peptide (Aβ) as well as intracellular neurofibrillary tangles composed mainly of hyperphosphorylated tau protein, are used for post-mortem confirmation of the diagnosis of Alzheimer's disease (AD). However, a …
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Processing of Alzheimer's amyloid precursor protein in cultured cells.
The deposition in the brain of the 4 kDa beta-amyloid peptide (betaA4), from amyloid precursor protein (APP), is a key pathology in Alzheimer's disease (AD). The single APP gene is spliced to give 3 major isoforms. In the majority of body tissues, the most common APP isoforms are APP[751] and …
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Analysis of gamma secretase regulation by phosphatidylethanolamine using mammalian and Drosophila melanogaster in vitro and in vivo model systems
A?-amyloid peptide (A?), that plays a central role in the pathogenesis of Alzheimer’s disease is derived by sequential proteolytic processing from the amyloid precursor protein (APP) by ?- and ?-secretase. APP is additionally processed through a non-amyloidogenic pathway by ?-secretase. Recent work …
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Model membrane interactions with ions and peptides at the air/water interface
The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated biochemical processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. …
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Development of analytical methodology based on chromatographic and mass spectrometric techniques for the characterization and fingerprinting of bioactive compounds of Crocus sativus L.
… of the noncovalent interaction between beta amyloid peptide Aβ(1-40) and Crocus-derived bioactive compounds natural products (such as crocins with different number of carbohydrate moieties). In conclusion, the application of MALDI high energy CID to structure elucidation of Crocus-derived …
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