Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Amyloid cascade hypothesis"”.
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Studying Models of the Amyloid Cascade Hypothesis Using Single-Molecule Imaging
Observation of beta-amyloid (Aβ) plaques in the brains of Alzheimer’s disease (AD) patients led to the development of the amyloid cascade hypothesis (ACH), which postulates the accumulation of Aβ as the initiator of AD. Aβ can be found in multiple forms in the AD brain; while the insoluble plaques …
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Development of amyloid beta binding bifunctional chelators for diagnosis of Alzheimer’s disease
… hypotheses proposed for the mechanism of AD, the amyloid cascade hypothesis is the most widely held. The amyloid cascade hypothesis states that the deposition of amyloid plaques, which is the characteristic pathological feature found by brain autopsy in patients with AD, is the main cause of AD. …
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Lipid Regulation as a Critical Factor in the Development of Alzheimer's Disease
… two decades, researchers have been led by the amyloid cascade hypothesis, which assumes that accumulation of the amyloid peptide Aβ, derived by proteolytic processing from the amyloid precursor protein (APP), is the key pathogenic trigger in AD. To date, therapies have largely focused on …
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Investigating the therapeutic potential of cannabidiol for Alzheimer’s disease: Using Caenorhabditis elegans that express the amyloid-beta protein
… those associated with ageing. The prevailing hypothesis of AD pathology, the amyloid cascade hypothesis, assumes that the accumulation of the amyloid-beta (Aβ1–42 ) protein is the causative agent. AD has no cure and current treatments provide limited therapeutic benefits. Cannabidiol (CBD) is …
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Evaluation of F-18 Labeled Hydroxy Quinoline Derivative as a Potential PET Imaging Agent for Early Detection of Alzheimer’s Disease
… mechanisms with high sensitivity. Based on the amyloid cascade hypothesis, congo red and thioflavine derivatives have been investigated as potential PET ligands that bind specifically to the amyloid plaques. Another hypothesis, the metal hypothesis, suggested that elevated level of metals …
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New Insights Regarding the Intracellular Effects, Trafficking, and Quality Control of the Amyloid Precursor Protein: Implications for Alzheimer’s Disease Pathogenesis
… presenilin proteins, and APP, which encodes the amyloid precursor protein (APP). Several hypotheses exist for the pathogenesis of AD. According to the amyloid cascade hypothesis, AD pathogenesis is associated with a series of molecular events which leads to the aggregation and deposition of …
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Effect of Neurotoxic Insults in Knock Out Cell Lines for the Study of Alzheimer's Disease
… Αν και η υπόθεση του καταρράκτη του αμυλοειδούς (Amyloid cascade hypothesis) παραμένει κεντρική στην παθογένεση της AD, από μόνη της δεν επαρκεί για να περιγράψει πλήρως την πολύπλοκη και πολυπαραγοντική φύση της νόσου. Επιπλέον, ο φυσιολογικός ρόλος των πρωτεϊνών που εμπλέκονται στην παθογένεση …
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Characterisation of transgenic mouse models of Alzheimer's disease
… as a research tool and carries mutations in the amyloid precursor protein (Swedish APP K670N/M671L), presenilin 1 (PS1M146V) and tau (TauP301L) which results in the development of pathological features simlar to the plaques and tangles observed in human AD. The TASTPM mouse carries both the APP …
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Quartz Crystal Microbalance Analysis of Amyloid-Beta Intermediate Aggregate Assembly: Kinetic Evaluation and theImportance of Physiological Parameters
… that pathogenesis can be explained through the `amyloid cascade hypothesis'. This hypothesis states that as the peptide amyloid-β (Aβ) aggregates to form insoluble plaques which deposit in the brain tissue of AD patients, it triggers a sequence of events culminating in neuronal cell death. It has …
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Modeling Alzheimer's Disease in Induced Pluripotent Stem Cells
… of extracellular plaques of aggregated amyloid-β (Aβ) and intracellular neurofibrillary tangles of tau aggregates (NFTs). Autosomal dominant inheritance of AD has been attributed to genetic mutations in three key genes: amyloid precursor protein (APP), presenilin-1 (PSEN1), and …