Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Amyloid burden"”.
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The Role of TNF Signaling in Regulating Beta-Amyloid Burden in the 3xTgAD Mouse Model of Alzheimer's Disease
… contributes to the increased microglial burden and exacerbated pathology observed in the hippocampus and cortex of 3xTgAD mice (transgenic mouse expressing human familial AD mutations in APP, PS1, and a familial frontotemporal dementia mutation in tau) after chronic systemic LPS exposure, …
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Étude des liens entre les mesures quantitatives de la vascularisation cérébrale, les fonctions cognitives et la neuropathologie dans la maladie d’Alzheimer
… as hippocampal atrophy, cerebral atrophy, and amyloid burden; iii) cognitive decline. Methodology: Participants were selected from the OASIS-3 database. Intracranial arteries were assessed by time-of-flight magnetic resonance angiography (TOF-MRA) and their quantitative measurements were …
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The Impact of Gamma Stimulation on Neurological Phenotypes of Alzheimer's Dementia and Down Syndrome
… Alzheimer’s disease (AD) pathology such as amyloid and tau levels, prevented cerebral atrophy, and improved behavioral testing performance in mouse models of AD. This thesis work focuses on the translation of this intervention into human patients with AD. Initial pilot studies assessed …
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Sex-Differences in Early-Onset Alzheimer's Disease
… with increased disease risk and pathology burden, but this has not been examined in Early-onset AD (EOAD; onset <65). Using data from the Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS), we examined sex and apolipoprotein E ε4 (APOE ε4) carrier status as predictors of …
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Genetic determinants of rates of cognitive decline in preclinical Alzheimer’s Disease
… of a trial. While brain imaging to determine Aβ- amyloid burden has utility in identifying individuals with preclinical AD, further work needs to be conducted to determine what influences rates of change during these early disease stages. Of particular focus is the rate of decline in cognitive …