"Amyloid beta-protein precursor" · 2 results · Global ETD Search

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Showing 1 to 2 of 2 for “"Amyloid beta-protein precursor"”.

Genetic Reduction of Cholesterol Synthesis in the Mouse Brain Does Not Affect Amyloid Formation in an Alzheimer’s Disease Model, but Does Extend Lifespan

Warren, Rebekkah Lynn2011

… content or synthesis affect the cleavage of amyloid precursor protein (APP) to amyloidogenic peptides characteristic of Alzheimer’s disease (AD). To determine whether a decrease in cholesterol synthesis would affect APP processing in vivo, we crossed cholesterol 24-hydroxylase knockout (KO) …

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Investigating the Role of the Amyloid Precursor Protein in the Pathogenesis of Alzheimer's Disease

Lefort, Roger2011

… from the accumulation and deposition of the amyloid-β peptide (Aβ) and the aggregation of hyperphosphorylated tau protein, respectively. Aβ is formed upon sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases and is secreted extracellularly. The accumulation of …

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