Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Amyloid beta-protein"”.
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Temperature dependence of amyloid beta-protein fibrillization
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Physics, 1999.
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Effects of Osmolytes on Amyloid-beta Protein Surface Activity and Membrane Interactions
The misfolding and aggregation of proteins into fibrillar aggregates in the brain are linked to the pathogenesis of over 20 neurodegenerative diseases. Specifically, the toxicity and neurodegenerative symptoms of Alzheimers disease are directly related to the aggregation of the amyloid-β (Aβ) …
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Investigating the therapeutic potential of cannabidiol for Alzheimer’s disease: Using Caenorhabditis elegans that express the amyloid-beta protein
… The prevailing hypothesis of AD pathology, the amyloid cascade hypothesis, assumes that the accumulation of the amyloid-beta (Aβ1–42 ) protein is the causative agent. AD has no cure and current treatments provide limited therapeutic benefits. Cannabidiol (CBD) is a cannabinoid derived from …
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A study of the elongation of fibrils of the Alzheimer's amyloid beta protein with a coarse-grained force field
… yet well understood, research points to a small protein, the beta-amyloid peptide (Abeta), as the first suspect. Ab chains are present in the brains of healthy individuals, but in AD patients, they associate and form clumps that deposit outside neurons, and are believed to trigger the disease. In …
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Protein production and applications of NMR in pharmaceutical sciences
The objective of Part I (Protein production for structural elucidation using NMR) is to design and develop strategies of producing amyloid beta protein for structural analysis using NMR. Amyloid beta oligomers are considered to be key elements causing Alzheimer’s disease and the elucidation of the …
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Amyloid Fibril Nucleation In Reverse Micelles
The 40-residue amyloid beta protein (Abeta) is the unstructured cleavage product of a common membrane protein that is produced in large quantities, but normally cleared from the brain before it exerts any apparent toxicity. Under some conditions, however, it undergoes a conformational change and …
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AB affects apoE transcriptionally through the activation of B-AR, cAMP and AP-2
… the development of Alzheimer’s disease (AD) are amyloid beta protein (Aβ) and apolipoprotein E (apoE). We and others have reported that Aβ elevates apoE protein levels in astrocytes, which in turn could alter lipid trafficking and cell function. The mechanism for the Aβ-induced increase in apoE …
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Beta-Amyloid oligomeric and monomeric states: implications for Alzheimer's Disease
… a predominant idea refers to the crucial role of amyloid-beta protein (Abeta) in the pathogenesis of the disease; in fact, the feature in the brain of AD patients is the presence of extracellular plaques mainly composed of Abeta. Nevertheless, Abeta is physiologically produced in healthy …
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An Insight into Alpha-Synulcien's Biological Function and Its Pathogenesis in Neurodegenerative Disease
… we identified a significant increase in amyloid beta -peptides. Protein quantification of apolipoprotein E (ApoE) a protein that has been associated with the development of Alzheimer's disease, demonstrated a 5-15 fold increase in symptomatic transgenic mice. Ablation of ApoE in alpha …
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Genetic Reduction of Cholesterol Synthesis in the Mouse Brain Does Not Affect Amyloid Formation in an Alzheimer’s Disease Model, but Does Extend Lifespan
… content or synthesis affect the cleavage of amyloid precursor protein (APP) to amyloidogenic peptides characteristic of Alzheimer’s disease (AD). To determine whether a decrease in cholesterol synthesis would affect APP processing in vivo, we crossed cholesterol 24-hydroxylase knockout (KO) …
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Extracting Ramachandran torsional angle distributions from 2D NMR data using Tikhonov regularization /
… constraints on the secondary structure of proteins and polypeptides. Amyloid fibrils implicated in a broad class of diseases such as Alzheimer's are known to contain a particular repeating structural motif, called a /5-sheet. However, the details of such structures are poorly understood, …
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Investigating the Role of the Amyloid Precursor Protein in the Pathogenesis of Alzheimer's Disease
… from the accumulation and deposition of the amyloid-β peptide (Aβ) and the aggregation of hyperphosphorylated tau protein, respectively. Aβ is formed upon sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases and is secreted extracellularly. The accumulation of …
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The role of complement FH and apoE interactions in the regulation of Aβ1-42 and C1q-mediated complement activation
The APOE4 gene variant of apolipoprotein E (apoE) has been identified as a predisposing factor for late-onset Alzheimer’s disease (AD). ApoE is known to interact with one of the classically characterized hallmarks of AD, the amyloid-beta (Aβ) protein. Aβ activates the classical complement pathway …
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Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease
… disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. The neuropathologic hallmarks of AD have been observed also in cognitively healthy …