Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Amyloid beta peptide"”.
-
A renewed vision for Amyloid beta and tau in Alzheimer s disease pathophysiology
… interactors involved in AD pathogenesis, i.e. Amyloid-beta peptide and tau protein, on hippocampal synaptic plasticity and memory in animal models. After reviewing the pathophysiological models that have been developed so far, our general purpose was to study novel aspects of Amyloid-beta …
-
Influence of Kaempferol on Noncanonical DNA Structures and Protein Aggregation
… as well as delay the formation of b-sheet in amyloid-beta peptide (Ab) further eluding to the potential of KMP as a possible natural therapeutic drug.</p>
-
Investigating the process of fibril formation of the Iowa mutant of the Alzheimer's peptide
… this study is to determine how the length of the beta-amyloid peptide, the specific region of the peptide, and a single point mutation affect the behavior of Alzheimer’s beta-amyloid. The beta-amyloid peptide, which is a 40 residue peptide that has been implicated as a potential cause of …
-
Alzheimer's disease and dementia with Lewy bodies: Special focus on the role of serpins
… senile plaques, mainly composed of aggregated amyloid-beta peptide (Abeta1-42), but also serpins, and neurofibrillary tangles of hyperphosphorylated tau protein. Pathological hallmarks of DLB include aggregates of alpha-synuclein (Lewy bodies), however, co-existing AD pathology is also …
-
Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
<p>The aggregation and accumulation of the amyloid beta peptide in the brain is hypothesized to be an initial necessary event in the pathogenesis of Alzheimer's disease (AD). Since the level of monomeric soluble amyloid beta as well as amyloid beta-binding molecules determine the onset and amount …
-
Dynamic Measurement Of Soluble Human Aβ In A Combined Microdialysis-Experimental Traumatic Brain Injury Mouse Model
The amyloid-β peptide: Aβ) plays a central pathophysiological role in Alzheimer's disease, but little is known about its dynamics in the brain's extracellular space. A recent microdialysis-based study in human patients with severe brain injuries found that extracellular Aβ dynamics …
-
X-ray Spectroscopic Studies of Model Compounds With Relevance to Nickel Superoxide Dismutase, Nitrile Hydratase and Copper Related Neurodegenerative Disorders
… of oxidation of the Cys residues. A metallopeptide mimic was synthesized and then sequentially oxygenated to its active form, a sulfinate (SO<sub>2</sub>) and a sulfenic acid (SOH). Over or under oxidation result in no activity of the metellopeptide mimic. The Aβ (amyloid-β) …
-
Purification and characterization of A[beta] and probing the interactions between myricetin and A[beta] using various spectroscopic methods
… of a naturally occurring protein fragment, the amyloid [beta]-peptide (A[beta]). Soluble oligomers of A[beta] are now considered to be the primary neurotoxic agent. Naturally occurring flavonoid compounds have been reported to inhibit/reverse A[beta] aggregation and reduce the A[beta]-induced …
-
Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model
… characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative diseases. However, more recent work has begun to suggest that the formation of ordered inclusions serves a …
-
Model membrane interactions with ions and peptides at the air/water interface
The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated biochemical processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. …
-
EXPLORING THE EFFECTS OF PHYSIOLOGICAL ENVIRONMENT ON AMYLOID AGGREGATION
… of protein molecules results in formation of amyloid deposits, that has been associated with neuronal dysfunction leading up to neurodegeneration. The protein aggregation is often influenced by several external physiological features, which can modulate this pathological process in a specific …
-
Quantitative Proteomics Analysis of Differentially Expressed Proteins in Aβ(17-42) Treated Synaptosomes
… have an extensive deposition of Aβ(17-42) peptide, which could contribute to their increased rate of developing Alzheimer's disease (AD). Since AD cannot be properly diagnosed until autopsy, development of a novel Down syndrome model using Aβ(17-42) could be beneficial in determining …
-
Small Molecule Binding to Disordered Proteins
… the interaction of a drug-like molecule with a peptide from an oncogenic transcription factor, c-Myc, in Chapter 2. I observed this interaction to be of entropic nature, and characterise the binding at the atomic level using simulations restrained with NMR data. The binding is extremely dynamic, …