Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Amyloid beta (Aβ)"”.
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Examining the binding of humanin and acetylcholinesterase with amyloid beta
<p>The importance of amyloid-beta (Aβ) in the development and progression of Alzheimer’s disease (AD) is currently well-recognized. Aβ was recently shown to be protective against certain types of cancer and capable of inhibiting the growth of tumor cells. The mechanisms by which Aβ is converted …
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The Impact of Insulin signalling on a C. elegans Alzheimer’s Disease Model
… elegans model overexpressing human amyloid beta (Aβ) peptides, a hallmark of AD pathology. My findings reveal that C. elegans overexpressing Aβ exhibit phenotypes, including impaired neuronal morphology, decreased mobility, and reduced chemotactic responsiveness compared to wild-type …
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Endocytic Trafficking of The Amyloid Precursor Protein In Rat Cortical Neurons
<p>Amyloid-beta (Aβ) aggregation and deposition into extracellular plaques is a hallmark of the most common forms of dementia, including Alzheimer’s disease. The Aβ-containing plaques result from pathogenic cleavage of amyloid precursor protein (APP) by secretases resulting in intracellular …
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STRESS GRANULES MODULATE SYK TO CAUSE MICROGLIAL DYSFUNCTION IN ALZHEIMER’S DISEASE
… brains of Alzheimer’s patients are recruited to amyloid beta (Aβ) plaques and exhibit an activated phenotype, but are defective for plaque removal by phagocytosis. To explore the molecular basis for these phenomena, I hypothesized that defects in the functions of the protein-tyrosine kinase SYK, …
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The Effect of Grapes in Mice with Alzheimer's Disease and Brain Injury
… in cognitive and memory deficits and deposits of amyloid beta (Aβ) in the cortex and hippocampus are thought to be significant contributors to the disease process. Increasing evidence suggests that foods rich in polyphenols, such as pomegranates and grapes, may have neuroprotective effects in both …
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Angiotensin-converting enzyme cleavage of the Alzheimer's beta-amyloid peptide
… it has been shown that ACE hydrolyses the amyloid beta (Aβ) peptide, the putative causative agent of AD. This study aimed to investigate the molecular basis of ACE hydrolysis of Aβ by determining : 1) the kinetic parameters of five different forms of human ACE with various N-terminal …
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Cross-Seeding Potential of Misfolded Amyloid-Beta Strains On Tau Protein: Examining The Puzzle Pieces of Alzheimer'S Disease
… the extracellular accumulation of misfolded amyloid-beta (Aβ) and the intraneuronal buildup of tau neurofibrillary tangles (NFTs). Compelling evidence suggests that Aβ triggers tau accumulation. Both of these disease-associated proteins are known to contribute to the typical AD associated …
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Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis
… are responsible for the cleavage of the amyloid precursor protein (APP) and generation of amyloid beta (Aβ). To date, γ-secretase proteases have over 120 substrates which demonstrate contribution to a diverse range of cellular processes and signalling events. However, recent findings have …
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Onset of Insulin Resistance in Hippocampal Synapses After Traumatic Brain Injury: Relevance to Alzheimer’s disease and Therapeutic Implications
… signaling increases synaptic sensitivity to amyloid beta (Aβ) and tau, thus contributing to the cognitive decline that characterizes this neurodegenerative disorder. Considering this, I used male Sprague-Dawley rats that underwent a lateral fluid percussion injury (FPI) at acute (2 and 7 days …
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The role of the E2 copper binding domain in the cell biology of the amyloid precursor protein
… by the accumulation, in the brain, of neurotoxic amyloid beta-(Aβ) peptides. These peptides are generated from the amyloid precursor protein (APP) via the amyloidogenic proteolytic pathway which also leads to the formation of soluble APP beta (sAPPβ). Alternatively, APP can be cleaved by the …
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Investigating KCC2 activity in Amyloid Precursor Protein (APP) associated Alzheimer’s Disease
… of sticky protein clumps in the brain known as amyloid-beta (Aβ) plaques, which are formed from specific fragments of the amyloid precursor protein (APP). The intact form of APP is essential for synaptic function; however, much remains to be explored regarding the impact of APP processing on the …
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Effect of anti-microbial immunizations in the progression of amyloid and neuroinflammatory pathologies in a mouse model of Alzheimer's disease
… promoting the biological drivers of AD, namely amyloid-beta (Aβ) aggregation, tau deposition in the brain, and neuroinflammation. While the unmodifiable risk factor of aging is the most relevant one to increase the risk of dementia, several factors can be modified to reduce the incidence of AD. …
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Alzheimer's Disease and Amyloid Beta: Effects of amyloid beta on hippocampal and dorsal root ganglion neurons' electrophyiology and morphology
… Saskatchewan alone. AD results from pathological amyloid beta (Aβ) peptides that hamper neurons’ communication, cause progressive neuronal cell death in the central nervous system, and ultimately lead to memory loss in the individual. While disease symptoms are well known, the mechanism by which …
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Phenotyping Double Transgenic Mouse Models of Alzheimer’s that Express Human APP and ApoE3 or ApoE4
… behavioral problems resulting from a build-up of amyloid-beta (Aβ) plaques in the brain. The degree of neuropathology is partially related to apolipoprotein E (apoE), a fat-binding protein involved in transporting cholesterol to neurons. The APOE gene, which codes for the production of apoE, has …
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Design and Synthesis of a Novel Neuroprotective Brain-Targeting Amylin Receptor Antagonist
… peptide that provides neuroprotection against amyloid beta (Aβ)-induced cell death and toxicity. Additionally, AC253 has been shown to improve spatial memory in mouse models of Alzheimer’s disease (AD). Screening of short overlapping fragments (12-mer) of AC253 showed that N-terminal residues …
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Field Amplified Sample Stacking on Amyloid Beta (1-42) Oligomers using Capillary Electrophoresis
… it is believed that the oligomeric form of amyloid beta (Aβ) is the leading cause of Alzheimer’s disease (1; 8; 10; 12-18). Additionally, recent studies have eluded to the impact of Alzheimer’s disease (AD) both economically and Socially in today’s society where an increase of about 71% of …
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Modulation of Alzheimer’s Disease Pathology by Collagen-Induced Rheumatoid Arthritis in APP/PS1 Mice
… arthritis (CIA) on cognitive function, amyloid plaque formation, microglial activation, and cerebrovascular pathology in the cortex and hippocampus of the double transgenic APP/PS1 mouse model for AD. Wild-type or APP/PS1 mice that received type II collagen (CII) in complete Freund’s …
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Understanding the molecular bases of neurodegeneration: From the structural characterisation of the aggregates to the establishment of an iPSC-derived neuronal model
… formed during the aggregation process of the amyloid beta (Aβ) peptide, which are thought to play a critical role in the pathogenesis of AD, and to be a main source of cellular dysfunction. In the first part of the thesis, we characterize the physio-chemical properties and the biological …
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Epigenetic Modulation of Synaptic Resilience in Alzheimer’s Disease
… their cognitive function despite the presence of amyloid plaques and tau tangles typical of symptomatic Alzheimer’s Disease (AD). In NDAN, unlike AD, toxic amyloid beta (Aβ) oligomers do not localize to the postsynaptic densities (PSDs). Synaptic resistance to amyloid beta in NDAN may therefore …
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Early Onset Alzheimer’s Disease Markers in Mouse Hippocampus Unveiled by Single-Cell Transcriptomic Analysis Following Cranial Radiotherapy
… CA1-3 regions, along with other alterations in Amyloid beta (Aβ) clearance markers such as CST3, APOE, APOE, APOJ/CLU, TREM2 and PIEZO1. We also identified downregulation of several ribosomal genes in pyramidal cells of the hippocampal CA1-3 regions in radiated mice. Comparisons between the …
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