Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 193 for “"Amyloid beta"”.
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Temperature dependence of amyloid beta-protein fibrillization
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Physics, 1999.
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Mechanisms of Brain Region-Specific Amyloid-beta Deposition
… region-specific deposition of extracellular amyloid plaques principally comprised of the amyloid-β: Aβ) peptide. Using mouse models of cerebral Aβ deposition, we examined molecular, cellular and systems-level mechanisms that regulate brain region-specific Aβ accumulation …
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Alzheimer's Disease and Amyloid Beta: Effects of amyloid beta on hippocampal and dorsal root ganglion neurons' electrophyiology and morphology
… Saskatchewan alone. AD results from pathological amyloid beta (Aβ) peptides that hamper neurons’ communication, cause progressive neuronal cell death in the central nervous system, and ultimately lead to memory loss in the individual. While disease symptoms are well known, the mechanism by which …
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The Effects of Apolipoprotein E on Amyloid-beta Induced Neurodegeneration.
The Effects of Apolipoprotein E on Amyloid-beta Induced Neurodegeneration.
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Examining the binding of humanin and acetylcholinesterase with amyloid beta
<p>The importance of amyloid-beta (Aβ) in the development and progression of Alzheimer’s disease (AD) is currently well-recognized. Aβ was recently shown to be protective against certain types of cancer and capable of inhibiting the growth of tumor cells. The mechanisms by which Aβ is converted …
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Amyloid-beta signaling in physiology and pathology: from astrocytes to SUMO
… progressive dementia and histopathologically by amyloid plaques and neurofibrillary tangles. The primary molecular culprit in AD is the amyloid-beta (Abeta) peptide, aggregates of which are the main components of the plaques. Numerous studies have implicated soluble Abeta oligomers as the …
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Rational Design and Application of Antibodies for Amylin and Amyloid Beta
… proteins and polypeptides such as amylin (islet amyloid polypeptide, IAPP) and amyloid beta are associated with numerous age-related pathological conditions such as Alzheimer's, Parkinson's, and type II diabetes, but effective treatments for these diseases are currently lacking. Antibodies have …
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Serotonergic Signaling Pathways that Suppress Amyloid Beta in Mouse Models of AD
… events as their brains become riddled with beta amyloid plaques. Alzheimer's is especially terrifying because there currently are no effective treatments for slowing or stopping the disease. However, recent research has shown that plaque formation is correlated to concentrations of amyloid …
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The role of Hsp60 in Amyloid beta toxicity: Relevance to Alzheimer’s disease
… leading to AD is the synaptotoxic effect of amyloid beta oligomers (Abo). These oligomers are formed by the misfolding and subsequent aggregation of Ab, a cleavage product of the amyloid precursor protein (APP). Furthermore, compelling evidence suggests that an age-related failure of the …
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The role of Hsp60 in Amyloid beta toxicity: Relevance to Alzheimer’s disease
… leading to AD is the synaptotoxic effect of amyloid beta oligomers (Abo). These oligomers are formed by the misfolding and subsequent aggregation of Ab, a cleavage product of the amyloid precursor protein (APP). Furthermore, compelling evidence suggests that an age-related failure of the …
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Effects of Osmolytes on Amyloid-beta Protein Surface Activity and Membrane Interactions
… are directly related to the aggregation of the amyloid-β (Aβ) protein into β-sheet rich insoluble fibrils. However, the mechanism and driving forces of Aβ fibril formation in vivo are still unknown. It has been shown previously that Aβ's surface activity and favorable interaction with lipid …
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Development of amyloid beta binding bifunctional chelators for diagnosis of Alzheimer’s disease
… hypotheses proposed for the mechanism of AD, the amyloid cascade hypothesis is the most widely held. The amyloid cascade hypothesis states that the deposition of amyloid plaques, which is the characteristic pathological feature found by brain autopsy in patients with AD, is the main cause of AD. …
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Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
<p>The aggregation and accumulation of the amyloid beta peptide in the brain is hypothesized to be an initial necessary event in the pathogenesis of Alzheimer's disease (AD). Since the level of monomeric soluble amyloid beta as well as amyloid beta-binding molecules determine the onset and amount …
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A renewed vision for Amyloid beta and tau in Alzheimer s disease pathophysiology
… interactors involved in AD pathogenesis, i.e. Amyloid-beta peptide and tau protein, on hippocampal synaptic plasticity and memory in animal models. After reviewing the pathophysiological models that have been developed so far, our general purpose was to study novel aspects of Amyloid-beta …
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Field Amplified Sample Stacking on Amyloid Beta (1-42) Oligomers using Capillary Electrophoresis
… it is believed that the oligomeric form of amyloid beta (Aβ) is the leading cause of Alzheimer’s disease (1; 8; 10; 12-18). Additionally, recent studies have eluded to the impact of Alzheimer’s disease (AD) both economically and Socially in today’s society where an increase of about 71% of …
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Development of multifunctional compounds for the modulation and detection of amyloid beta species
… Alzheimer’s dementia currently. The presence of amyloid plaques and neurofibrillary tangles in the brain is the hallmark of AD. Amyloid β (Aβ) peptides, the main component of amyloid plaques, are formed from the cleavage of amyloid precursor protein (APP) by β- and γ-secretases. The main …
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The Role of Apolipoprotein E Concentration and Isoform in Amyloid-beta Metabolism In Vivo
… lesions, one of which is the accumulation of the amyloid-β: Aβ) peptide into extracellular amyloid plaques. Several autosomal dominant mutations have been shown to cause familial forms of early-onset Alzheimer's disease, but factors that modulate the risk and onset for the more common …
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